Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 60 for “"Quantification method"”.
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Investigation of a solvent-free continuous process to produce pharmaceutical co-crystals. Understanding and developing solvent-free continuous cocrystallisation (SFCC) through study of co-crystal formation under the application of heat, model shear and twin screw extrusion, including development of a near infrared spectroscopy partial least squares quantification method
… solvent-free continuous cocrystallisation (SFCC) method to manufacture pharmaceutical co-crystals. The objectives were to optimize the process towards achieving high co-crystal yields and to understand the behaviour of co-crystals under different conditions. Particular attention was paid to the …
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Development and partial validation of a method for the quantification of benzodiazepines and antidepressants in whole blood, serum and urine by liquid chromotography - Tandem mass spectrometry
The aim of this project is to develop a single quantification method for certain benzodiazepines, opiates and antidepressants in whole blood, serum and urine by LC-MS/M5 and to consequently validate the analytical method for official use in the Division of Pharmacology at the University of Cape …
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Biomarker analysis for APRT deficiency diagnosis using UPLC-MS/MS
… stones in APRT deficiency patients. UPLC-MS/MS method for simultaneous quantification of DHA, adenine and the drugs, allopurinol, oxypurinol and febuxostat in human plasma had been developed. The objective of this study was to perform full validation of the UPLC-MS/MS quantification method …
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Deep Learning-based Time Series Forecasting: Models and Applications
… studies the point estimation and uncertainty quantification of time series forecasting based on deep learning methodology. This thesis achieves research contributions as follows: (1) It proposes a point estimation network based on noisy residual connection and snapshot ensemble forecasting …
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Statistical Evaluation of the Factors causing Microbial Growth in Point-of-use Filters
… The applicability of flow cytometry results as a quantification method was validated and then used to quantify the biological growth. Our results revealed that the installation of POU filters may lead to nitrification and an increase in microbial growth. Along with the increase in microbial …
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A Quantitative Study of Drug Recrystallization in Drug-In-Adhesive Transdermal Patches Using Vibrational Spectroscopy
… API in DIA systems. This approach uses a novel method of preparing calibration standards and a spectroscopic method to reliably predict crystalline content in DIA patches. Spectroscopic tools, including Raman spectroscopy and near-infrared spectroscopy (NIRS), were used to determine the …
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Investigating normal human gene expression in tissues with high-throughput transcriptomic and proteomic data.
… of proteomic data, I introduce a new proteomic quantification method, PPKM (Chapter 5). The PPKM method allows me to quantify about twice as many proteins compared to usual methods. Limited numbers of previous studies have shown various correlation levels between the expression of protein and …
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Uncertainty quantification and calibration of physical models
… and simplification of the physical model. Quantification of uncertainty of such an ecosystem model is computationally very heavy. Bayesian calibration method has been used as an efficient way to calibrate and quantify uncertainties of the computer models. In this work, I develop a new …
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Evaluation of human error probabilities for post-initiating events
… by three human reliability analysis methods are compared to determine the strengths and weaknesses of the methodologies and to identify how they may be best used. A Technique for Human Event Analysis (ATHEANA) has a unique approach because it searches and screens for deviation …
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Methodology for Quantifying Resiliency of Transportation Systems
… a quantitative reference. There is a need for a method of quantifying resilience to better plan and prepare for system wide disruptions. The research effort described herein provides a quantifiable measures of system resiliency, consistent with NSF’s definition. Fundamentally, a system disruption …
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Improved Visualization and Quantification for Hyperpolarized 129Xe MRI
… has been considerable interest in developing methods that can comprehensively evaluate lung function non-invasively and can provide 3D resolution. Therefore, there has been considerable interest in developing methods that can evaluate lung function comprehensively, non-invasively, and …
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Quantitative proteomics analysis in cultured skin fibroblasts from patients with rare genetic disorders
… as a cell model for the disease. A proteomics quantification method is applied to study the pathogenic alterations in these cells.
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On the evaluation of human error probabilities for post-initiating events
Quantification of human error probabilities (HEPs) for the purpose of human reliability assessment (HRA) is very complex. Because of this complexity, the state of the art includes a variety of HRA models, each with its own objectives, scope and quantification method. In addition to varying methods …
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DETECTION AND QUANTIFICATION OF BREAST ARTERIAL CALCIFICATION AS A BIOMARKER OF CARDIOVASCULAR RISK IN WOMEN
… of a standardised, robust, fast, and reliable quantification method, an issue that could potentially be solved by artificial intelligence-based methods. As such, more widespread assessment of BAC could help improve cardiovascular risk stratification in women supporting the decision-making …
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Quantifying soil particulate organic matter using image analysis
Rapid and cost-effective quantification of soil organic carbon (SOC) fractions that are responsive to management will improve soil health assessment and associated decision support tools. The particulate organic matter (POM) fraction of SOC is of interest due to its sensitivity to management and …
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Similarity-Augmented Prediction Methods for Neural Machine Translation
… beam search, and probability-based uncertainty quantification (UQ), e.g. Shannon entropy. In this thesis, we study a class of methods which measure semantic similarities between elements in the LM output distribution, which we call similarity-augmented prediction methods. The most well-known …
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Development of a Vascularized Carotid Artery Plaque Phantom for the Investigation of Novel Ultrasound-Based Technologies
… ultrasound (CEUS) technology, and its accurate quantification could provide a powerful tool for the detection of vulnerable plaque. This project was undertaken to develop a model of vascularized atherosclerotic plaque compatible with CEUS, and to apply it in the validation of a novel IPN …
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Novel Chemically Selective Rapid Magnetic Resonance Imaging Techniques and the Clinical Applications
… be improved by the development of novel imaging methods (pulse sequences), as well as by exploring the everyday clinical and research applications of these new methods. This dissertation focuses on two novel chemically selective imaging methods for the generation of high quality fat-only or …
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Genetic association between schizophrenia and type-2 diabetes
… the genes associated with obesity and T2D.<br/>Methods: A total of 221 British nuclear families consisting of 148 fathers, 204 mothers and 222 affected offspring with schizophrenia were recruited for the genetic analysis. All family members studied were of Caucasian descent, including English, …
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