Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"Quadruplex Binding Ligands"”.
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Synthesis and biophysical evaluation of thiazole orange derivatives as DNA binding ligands
… can form a unique DNA tertiary structure - G-quadruplex, which is known to inhibit the binding of telomerase to telomeric regions in cancer cells and thus regulate unrestricted cancer cell growth. Hence, G-quadruplex DNA has recently become a promising target in oncology. The formation of …
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The synthesis of macrocyclic molecules related to telomestatin
G-quadruplex DNA represents an attractive target for the development of anti-cancer therapeutic agents as it plays important roles in transcriptional regulation and the maintenance of telomeric length. Oxazole-containing macrocycles such as telomestatin are considered to be a promissing new class …
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The effect of replication impediments on differentiation
… DNA damaging agents, low dose hydroxyurea and G-quadruplex secondary structure stabilisation. DNA damage was induced both in the undifferentiated state and during differentiation. When damage was induced during differentiation, greater levels of cell death were seen and there was a larger …
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Porphyrin Cross-Linkers for Generating Soluble Molecularly Imprinted Polymers from Polyethyleneimine
… for the preparation of soluble MIPs targeting quadruplex DNA, specifically the human telomeric repeat (TTAGGG)<sub>4</sub>. To do so we have synthesized a series of <em>meso</em>-substituted, water soluble, tetracationic pyridinium porphyrins which we have successfully coupled to …