Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"Qki"”.
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Qki-Mediated Cholesterol Biosynthesis In Eye Lens and Myelin of The Central Nervous System
… of cholesterol biosynthesis. We found Quaking (Qki) is a novel transcriptional activator of cholesterol biosynthesis. Using transcriptomic profiling, we found cholesterol biosynthesis was the most downregulated pathway in Qki-depleted lens and brain. Indeed, mRNA and protein levels of …
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Qki-Mediated Cholesterol Biosynthesis In Eye Lens and Myelin of The Central Nervous System
… of cholesterol biosynthesis. We found Quaking (Qki) is a novel transcriptional activator of cholesterol biosynthesis. Using transcriptomic profiling, we found cholesterol biosynthesis was the most downregulated pathway in Qki-depleted lens and brain. Indeed, mRNA and protein levels of …
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Investigating The Role of Quaking In Antigen Uptake and Cross-Presentation By Dendritic Cells
… discovered that an RNA-binding protein, Quaking (QKI) plays a pivotal role in antigen uptake by DCs. Our previous studies in neural stem cells and microglia have identified QKI as a novel regulator of phagosomes and endolysosomes, and knocking down of QKI significantly downregulates genes involved …
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Investigating Potential Multi-Protein Complexes Involving Emx2
… two Emx2-interacting proteins, Cnot6l and QkI (which exists in three forms) that interact with each other. These interactions were initially identified by a yeast two-hybrid screen and then confirmed by pull-down assays. The goal of this project is to use GST pull-down assays determine …
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Confirmation of Emx2 Protein Binding Partners
… protein-protein interactions between Emx2 and QkI-7, Emx2 and Cnot6l, and Cnot6l and QkI-7. The results were positive for all three interactions. Additionally, Emx2 was found to bind the two other QkI isoforms, QkI-5 and QkI-6.
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Co-regulation of the Smooth Muscle Cell Alternative Splicing Programme by the RNA-Binding Proteins RBPMS, RBFOX2, MBNL1, and QKI
… In this study, I investigated RBFOX2, MBNL1, and QKI as potential co-regulators of RBPMS in VSMC AS regulation. RBFOX2 was identified as a key candidate due to enrichment of its GCAUG binding motifs around RBPMS-regulated exons in positions suggesting cooperative regulation. MBNL1 was selected for …
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NF-YA ISOFORMS ROLES IN CLAUDIN LOW CANCERS
… NF-YA alternative splicing, among which RBFOX2, QKI and CELF2 both in BRCA and in STAD cell lines. Through transient overexpression, I validated RBFOX2 as splicing factor promoting the maturation of NF-YAl. Finally, through a frameshift mutation in NF-YA gene, I have investigated the effect of …
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Dissecting the genomic and epigenomic alterations underlying glioblastoma
… target genes regulating NSC identity, including QKI, PTPRZ1 and CDK6. Intriguingly, SOX2/SOX9 co-binding also target their own and each other’s regulatory regions, suggesting the existence of an auto- and cross-regulatory feed-forward axis. Importantly, we observed no increased in mutational …