Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 29 for “"QR355 Virology"”.
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Transcription of herpes simplex virus type 2
Summary available: p. i-iv.
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Relating the structure of the HSV-1 UL25 DNA packaging protein to its function
The herpes simplex virus type 1 (HSV-1) UL25 protein (pUL25) is a minor capsid protein that is essential for packaging the full-length viral genome into preformed precursor capsid. It is also important in virus entry and recently has been implicated in the egress of the virus from the cell (Coller …
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Factors affecting replication and cross-species transmission of feline immunodeficiency virus
In order to successfully invade a new species, lentiviruses must overcome restriction factors, dominant blocks to replication, and be able to make use of available host factors such as entry receptors for replication. Human immunodeficiency virus (HIV-1) infection is blocked at a post-entry stage …
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Characterisation of the virulence-related, outer-membrane proteins of B. pertussis
At the beginning of this study, knowledge of autotransporter proteins was in its infancy and the B. pertussis proteins pertactin, BrkA and tracheal colonisation factor (Tcf) had not been recognised as members of this family. However, the sequence similarity between these Bordetella proteins and a …
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The contribution of viral and host cell factors to replication of the hepatitis C virus RNA genome
Studies on the hepatitis C virus (HCV) life cycle have been aided by the development of in vitro systems that permit replication of the viral RNA genome and virus particle production. However, the exact functions of the viral proteins, particularly those engaged in RNA synthesis, are poorly …
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Studies on the interaction of HSV-1 multifunctional protein ICP27 with the nuclear pore complex proteins
Herpes simplex virus (HSV-1) ICP27 is a multifunctional immediate early (IE) protein, required for expression of several early and late genes and acts at transcriptional and posttranscriptional levels. ICP27 contains both a nuclear localization signal and a nuclear export signal and shuttles …
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Adherence to and invasion of mammalian cell lines by Pasteurella multocida B:2
Haemorrhagic septicemia (HS), caused by the Gram-negative bacterium Pasteurella multocida serotype B:2, is an economically important disease responsible for morbidity and mortality of bovines, especially buffaloes, in countries of South or Southeast Asia and Africa. A feature of this disease is the …
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The role of the herpes simplex virus type 1 UL33 protein in DNA packaging
The UL33 gene of herpes simplex virus type 1 (HSV-1) encodes a 130 amino acid (aa) protein that is essential for the cleavage of concatemeric viral DNA into monomeric genomes and their packaging into preformed capsids. Several lines of evidence have suggested that UL33, along with the UL15 and UL28 …
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Characterisation of PP71 homologues encoded by mammalian cytomegaloviruses
Human cytomegalovirus (HCMV) is a human pathogen that can cause severe disease in immunocompromised or immunosupressed individuals and also in newborns infected in utero. Transcription of the viral genome occurs by a process in which three classes of HCMV genes, immediate early, early and late are …
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The interaction of hepatitis C virus and intracellular lipid metabolism
Chronic hepatitis C virus (HCV) infection causes inflammation of the liver, which can lead to fibrosis and cirrhosis over time. Whether liver damage is a consequence of viral infection or is due to an immune mediated response is not clear. Steatosis is a histopathological feature often found in HCV …
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Transcriptome activity of human cytomegalovirus (strain Merlin) in fibroblasts, epithelial cells and astrocytes
Global human cytomegalovirus (HCMV) gene expression was investigated during replication in three permissive human cell types in tissue culture; human foetal foreskin fibroblasts (HFFF-2), human retinal pigmented epithelial (RPE) cells, and human astrocytoma cells (U373Mg). A custom HCMV DNA …
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Identification of hepatitis C virus core protein residues critical for the interaction with the cellular DEAD-Box Helicase DDX3 and their functional relevance
Hepatitis C virus (HCV) is a single-stranded RNA virus belonging to the Flaviviridae and infects approximately 170 million people worldwide. Unlike other known RNA viruses, HCV causes a persistent infection in the majority of infected people and can lead to cirrhosis of the liver and hepatocellular …
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Cell surface interactions of Coxsackie A9 virus
An understanding of how viruses interact with their receptors is vital as this step is a major determinant of host susceptibility and disease. Coxsackievirus A9 (CAV9), an enterovirus, harbours an integrin- recognition motif, RGD (Arg-Gly-Asp), in the capsid protein VP1 and although modes of …
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Analysis of the interaction between the 2C protein of parechoviruses and lipid droplets
Picornaviruses are non-enveloped, positive sense single-stranded RNA viruses which cause many diseases ranging from slight illness to fatal meningitis and encephalitis. There are no vaccines against most picornaviruses so drugs need to be developed. Human parechoviruses (HPeVs) are being …
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Molecular Basis of Adaptation of Enteroviruses to Different Cancer Cell Lines
Viral oncolytic therapy, a novel treatment for cancer using specially designed viruses to kill malignant cells while leaving normal cells unharmed, is currently under intense investigation. Several receptors are up-regulated in cancer cells, including decay-accelerating factor (DAF; CD55) and …
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Characterisation of open reading frames m29 and m29.1 in murine cytomegalovirus
Murine cytomegalovirus (MCMV) in its natural host, the mouse, is an excellent model for studying the biology of cytomegalovirus infection. Mostly this model has been used to study gene homologues of human cytomegalovirus (HCMV). Of the predicted 170 MCMV open reading frames (ORFs) only 78 have …
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Epidemiology of Banana streak virus (BSV) in East African highland bananas (AAA-EA)
The study achieved a better understanding of the epidemiology and ecology of Banana streak virus (BSV) in Uganda, generating information useful in designing management strategies to limit the spread of BSV. An identification key for the mealybugs on Musa in Africa was constructed. Screenhouse …
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Micro-evolution of foot-and-mouth disease virus
Foot-and-mouth disease virus (FMDV) causes an acute vesicular disease of domesticated and wild ruminants, and pigs. The virus is highly variable with 7 serotypes and numerous subtypes. A method was developed to sequence the complete genome of the Pan Asia O serotype FMDV that caused the UK 2001 …
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The analysis of a conserved RNA structure in the 3D polymerase encoding region of Human Parechovirus 1
Picornaviruses are important causes of human illness and it is necessary to understand more about how these viruses function. Human parechoviruses (HPeV) are common pathogens and studies have shown that 95% of people become infected with HPeV at a very early age, usually with symptoms such as mild …
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