Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 40 for “"QR180 Immunology"”.
-
B cell signalling in mechanisms of central and peripheral tolerance
Tolerance against self is a necessary feature of the immune system to prevent autoimmunity. Hence during B cell development, a number of central and peripheral developmental checkpoints ensure the deletion of self-reactive B cells and selection of tolerant B cells. For example, antigen-driven …
-
Modulation of innate immunity by the cGMP signalling pathway in the drosophila malpighian tubule
The Drosophila innate immune system is one of the most widely characterised of all metozoan defense systems, and shares many similar characteristics to the innate immune systems of higher organisms. As such, Drosophila has become the model organism of choice for many researchers with regards to the …
-
The effects of ES-62 on DC maturation and effector function
Parasitic filarial nematodes are often tolerated in their human hosts for decades, with little evidence of pathology, due to parasite-induced immune modulation. The consensus of opinion, to date, is that such parasites achieve prolonged survival as a result of their active modulation of the host’s …
-
Expression and function of the αVβ5 integrin during human B lymphopoiesis
The integrin αVβ5 is a receptor for sCD23 molecule and the αVβ5-CD23 interaction sustains proliferation of the pre-B cell line SMS-SB. This thesis describes further investigation into the role of αVβ5 integrin during human B cell development. B cell development in the bone marrow involves stepwise …
-
Investigation of T cell signalling events regulating immunity and tolerance in vivo
Summary The ability of the immune system to discriminate between pathogenic and self or food antigens is essential not only for the generation of a productive immune response against invasive pathogens, but also for a state of antigen-specific tolerance to be elicited against harmless antigens. A …
-
The recognition of lipopolysaccharides present in Gram-negative bacteria by receptors of the immune system
Invasive bacterial infections cause severe systemic complications including a life-threatening condition known as septic shock. Sepsis results in a dysregulated systemic inflammatory immune response with systemic consequences. The function of the immune system requires efficient communication …
-
The role of Poly (ADP-ribose) polymerase in the regulation of innate recognition of immunological receptors expressed on human macrophages.
In order to combat harmful pathogens the innate recognition part of the immune system uses a variety of receptors including CD14, TLR4, TLR2 and SR (MARCO). These receptors are expressed on most human monocytes and macrophages. CD14 recognizes and bind lipopolysaccharide (LPS), the main causative …
-
Coordinate regulation of Vegf signalling genes by the proline rich homeodomain protein
PRH is a transcriptional repressor that regulates development of the haematopoietic and vascular systems. VEGF is a mitogen that stimulates cell survival via cell surface receptors including VEGFR1 and VEGFR2. This thesis identifies Vegf, Vegfr1, and Vegfr2 as bona fide PRH target genes and shows …
-
The role of NF-kB2 in secondary and tertiary lymphoid tissue development
The role of the alternative NF-\(\kappa\)B pathway in the development of secondary lymphoid organs (SLOs) has been well described. Tertiary lymphoid organs (TLOs) include intestinal cryptopatches (CPs) and isolated lymphoid follicles (ILFs). This thesis investigates the role of the alternative …
-
Signalling and function of the small Rho GTPase RhoJ in endothelial cells
RhoJ is an endothelial expressed Rho GTPase, and its knock-down impairs endothelial cell (EC) migration and tubulogenesis, increases stress fibre (SF) and focal adhesion (FA) numbers. This work aimed to determine the intracellular localisation of RhoJ, identify its binding partners, test how it is …
-
Role of the CTLA-4 receptor in regulatory T cell development, homeostasis and function
Autoimmunity can occur when self-reactive lymphocytes of the adaptive immune system are activated upon encounter with antigen. This can lead to the development of debilitating and potentially life-threatening autoimmune diseases such as type-1 diabetes, rheumatoid arthritis and multiple sclerosis. …
-
Recruitment and positioning of regulatory T cells and Th17/Tc17 in inflamed human liver
The liver is a unique tolerogenic organ with dual blood supply. Both regulatory lymphocytes and effector lymphocytes are present in the normal and inflamed liver along with innate immune cells. The balance between these two subsets of lymphocyte is crucial in maintaining immune homeostasis by …
-
Signals for B cell activation in antibody response
Germinal centres (GCs) are the sites where V-gene hypermutation and B cell selection are taking place. Testing specificity and affinity of GC B cell receptor by interaction with antigen on follicular dendritic cells (FDCs) may be an important selection process to select high affinity B cell clone. …
-
Early divergent B cell differentiation during antibody responses
The early B cell response to antigen is analyzed, probing the mechanisms of divergent differentiation into plasmablasts or germinal centre (GC) B cells. Heterozygous QMxB6 mice, in which 5% of B cells are specific for the hapten 4-hydroxy-3-nitrophenol (NP), were immunized with NP-Ficoll. Varying …
-
Studies on the transfer of immunity from mother to offspring in mice infected with Trichinella spiralis (nematoda)
Summary available: p. xix-xxii.
-
Immunomodulatory effect of pneumolysin upon CD4 T cells
The human bacterial pathogen, Streptococcus pneumoniae (the pneumococcus), has been shown to modulate different parts of the innate immune response of its host, however its ability to modulate the adaptive immune response remains largely uninvestigated. Furthermore, the importance of the adaptive …
-
Factors influencing the spread and selection of drug resistance in Human African Trypanosomiasis
A growing problem with drug resistance in Human African Trypanosomiasis has necessitated the implementation of screening programmes to monitor for its spread. This thesis describes the study of several factors that can influence the selection and propagation of drug resistance in T. brucei. Human …
-
Genetic analysis and characterisation of the BapC autotransporter of bordetella pertussis
The autotransporters are a family of extracellular proteins, found in various Gram-negative bacteria, that have many different functions but appear to have a similar mechanism of export. In B. pertussis, the virulence-regulated proteins Pertactin, BrkA, Tcf, and Vag8 have structural homology at …
-
Characterising the immune response to Salmonella and Salmonella surface antigens during a systemic infection
Immunity to Salmonella enterica serovar Typhimurium (STm) is complex and requires both cell mediated and humoral immunity at different stages of infection. In infants in sub-Saharan Africa infection with non-typhoidal Salmonella (NTS), such as STm, can commonly cause fatal invasive disease. …
-
Host-pathogen interactions in the innate immune response of the nematode Caenorhabditis elegans
The nematode Caenorhabditis elegans has been a powerful experimental organism for almost half a century. Over the past ten years, researchers have begun to exploit the power of C. elegans to investigate the biology of a number of human pathogens. This work continues to uncover mechanisms of host …
Page 1 of 2