Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 141 for “"QR Microbiology"”.
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New water-soluble porphyrins for oxygen sensing in protein-based materials
Oxygen is a vital molecule for life and its precise quantification is pivotal to ensure correct functioning of cells. Instruments able to quantify accurately the oxygen levels are extremely important to understand cells behaviour especially in a three-dimension (3D) environment, where uneven …
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Development of portable escherichia coli bacteria detection using resistive graphene-based immunosensor
Escherichia coli (E. coli) bacteria comes from the human and animal faeces. It is hazardous to human health and could cause death when not immediately treated. Therefore, it is crucial to detect E. coli bacteria in water before consuming it. Since many cases of water contaminated E. coli bacteria …
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Evaluation of anti-tuberculosis potentials of selected medicinal plants in Endau Rompin, Johor, Malaysia
Tuberculosis (TB) remains an escalating health crisis globally which prompts new approaches to find more effective therapeutic strategies. Medicinal plants of Malaysia have a significant role to play in being able to provide new therapeutic remedies. The local people of Kampung Peta (Jakun tribe), …
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Food safety management practices in the traditional fish processing sector in Ghana and the microbiological safety of selected processed fish products from Ghana
Fish products contribute significantly to protein nutriture, food security, livelihoods and the economy in West Africa. Food safety of processed fish products however remains an important concern. The purpose of this study was to investigate the safety of traditionally processed fish from Ghana. …
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Investigating the role of rhomboid proteases in the development of Dictyostelium discoideum
Dictyostelium discoideum is a model eukaryotic organism with many equivalent cellular mechanisms to humans. In this project Dictyostelium has been used to help investigate the role of rhomboid proteins. Bioinformatics tools were used to identify four potential rhomboids encoded within the …
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The application of molecular techniques for the rapid and sensitive detection of gastrointestinal pathogens directly in food
Conventional microbiological methods are slow, labour intensive and are unable to meet the demands for rapid food testing. Molecular methods, such as PCR, offer a rapid, sensitive and specific means of detecting pathogens, however loss of sensitivity and lack of robustness have been reported when …
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Rapid quantification of probiotic cultures using microcalorimetry
The potential of using microcalorimetry as a rapid method for the quantification of probiotic micro-organisms was investigated. The technique was based on two potential mechanisms: the metabolism of specific carbohydrate and the ability to metabolise glucose in the presence of inhibitors. In …
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The development and evaluation of improved rice parboiling technology in Ghana
A socio-economic study was carried out in northern Ghana to verify the importance of rice parboiling to poverty alleviation. Consumer acceptability and sensory evaluation carried out showed that there was a high correlation between consumer acceptability and sensory attributes developed by a …
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Fingerprinting and characterisation of Escherichia coli isolates using DNA arrays
Two commercially available DNA whole genome Escherichia coli K12 arrays were compared to identify a subset of markers for typing. The arrays were identical in probe composition but different in substrate (membrane and glass slide arrays) and probe preparation (radio- and fluorescent-labelled). …
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The effect of cAMP elevation on intracellular signalling pathways in prostate epithelial cells
Chronic IL-6 signalling contributes to the pathophysiology of many diseases including prostate cancer. Relevant to prostate cancer is the ability of the pro-inflammatory cytokine IL-6 to activate the oncogenic signalling protein STAT3, thus inhibition of STAT3 activation is a popular avenue of …
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Novel strategies to prevent and treat experimental pneumococcal disease
With over 90 different serotypes of Streptococcus pneumoniae unevenly distributed around the world, current vaccine formulations vary significantly in their ability to protect against invasive pneumococcal disease (IPD). The adult pneumococcal vaccine is composed of capsular polysaccharide from 23 …
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Analysis of the role of rab11-FIP3 phosphorylation during cytokinesis
Cytokinesis involves abscission of the intracellular bridge between two daughter cells, thus completing mitosis. Membrane traffic is at the heart of mammalian cytokinesis. Rab11-FIP3 (also referred to as FIP3) in complex with Rab11 plays a key role in the delivery and targeting of recycling …
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Modulation of Bordetella pertussis by nicotinic acid
Summary available: p. i-iii
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Studies on cathepsin B of Eimeria tenella and pyroglutamyl peptidase of Leishmania major
A sequence encoding a cathepsin B-like cysteine peptidase of the clan CA, family C1 was identified in the genome database of E. tenella. The sequence corresponded to a single copy gene, and did not carry any introns. The E. tenella enzyme, sharing 42% identity with the Toxoplasma gondii toxopain-1, …
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Investigations into quinolone and fluoroquinolone resistance in Salmonella enterica
Infections with Salmonella enterica usually present as a self-limiting diarrhoeal disease. Occasionally, antimicrobial intervention is required for invasive infection or patients with underlying disease or at the extremities of age. In adults the therapeutic agents of choice are the …
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Antigenic modulation in Bordetella pertussis
Summary available: p. ii.
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Characterisation and secretion mechanism of Bordetella pertussis autotransporter proteins
The identification and characterisation of new virulence determinants of 5. pertussis is providing important information for understanding the colonisation and survival strategies of the microorganism. B. pertussis deploys a range of surface-associated components to enable its successful …
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Intracellular triggering of inflammation by the extracellular bacterium Pseudomonas aeruginosa
Abstract P.aeruginosa is an extracellular, Gram-negative opportunistic pathogen. One of the most important virulence factors during infection is the type III secretion system (T3SS). This system is found exclusively in Gram-negative bacteria and it forms a conduit between the bacteria and the host …
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Characterisation of the role of AMP-activated protein kinase in 3T3-L1 adipocytes
AMP-activated protein kinase (AMPK) has been proposed to be a therapeutic target for patients with type 2 diabetes and the metabolic syndrome. In skeletal muscle AMPK stimulates glucose uptake and fatty acid oxidation, whereas in liver it inhibits fatty acid and cholesterol synthesis. The Rab …
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Regulators of autophagy in Leishmania major
Autophagy is a conserved lysosomal degradation pathway for recycling long-lived proteins and organelles that is thought to be required for life cycle progression and virulence of Leishmania. ATG8 is a ubiquitin like protein that is required for the formation of autophagosomes, and Leishmania …
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