Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 158 for “"QP Physiology"”.
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Examining endothelial function in humans in vivo: improving guidelines and exploring novel measures
Chapter 1 introduced the old and new measurement of endothelial function, and vascular health. The first part of this thesis focussed on the “old” flow-mediated dilation measurement, introduced in 1992, which relies on brachial artery vasodilation after a hyperaemic stimulus (e.g. after occlusion …
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The acute effects of shear rate maniuplation on vascular function in a healthy population
… highlight the complexity of haemodynamic physiology and suggest that factors other than retrograde SR may influence acute vascular function.
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Identification and characterisation of a novel, multi-potent, skeletal muscle-derived stem cell with broad developmental plasticity
PW1+/Pax7– skeletal muscle-derived interstitial progenitor cells (PICs) are myogenic in vitro, efficiently contribute to skeletal muscle regeneration in vivo, and are self-renewing in vivo whilst also giving rise to satellite cells (Mitchell et al. 2010). They have previously been identified in the …
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The structure and function of Gene's organ and its associated glands in ticks
… also concerns the ultrastructure and electrophysiology of the retractor muscles controlling the horns and their innervation. Evidence is presented implicating L-glutamate and L-aspartate as excitatory transmitters at the neuromuscular junctions.
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Dietary intake, lifestyles and risk of nutrition-related non-communicable diseases in a Punjabi south Asian male population in Kent, United Kingdom
Chronic nutrition related non-communicable diseases (NR-NCDs) are more prevalent in south Asians living in the United Kingdom compared to the general UK population. Observed differences have been attributed to inter-generational nutritional experiences and pattern of lifestyle changes which affect …
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Purification and characterisation of amylolytic enzymes from Lipomyces starkeyi
A purification scheme has been developed for the extracellular carbohydrases; aglucosidase and a-amylase, secreted by the ascosporogenous soil yeast Lipomyces starkeyi NCYC 1436. Growth and optimum enzyme yield conditions were determined with cultures of L. starkeyi grown at 30°C on a medium …
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Investigating the bioprotective properties of sugars
The purpose of this study was to investigate the stabilizing properties of osmolytes, specifically sugars on biomolecule such as protein. The strategy used in this study involved the utilisation of surfactant-rich micelles; where by the impact sugars have on the free energy of exposure of …
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The vasodilatory and antioxidant activities of polyphenolic substances
This project was designed to determine the effect of a wide range of grape and tea based extracts and green tea catechins on vascular tension in vitro, further determine the relationship between their vasodilatory and antioxidant activities and identify the major polyphenols present in green and …
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Arrhythmia mechanisms in acute ischaemia and chronic infarction in rabbit heart
… and the occurrence of arrhythmias. The electrophysiology of the epicardial surface of isolated hearts was examined using the voltage sensitive dye RH237 and optical action potentials were recorded from a 13x13mm area of left ventricular epicardium using a 16x16 element Hamamatsu photodiode …
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Effects of specifically sequenced massage on spastic muscle properties and motor skills in adolescents with cerebral palsy
Cerebral Palsy (CP) is the most common childhood disability, with an incidence around 2-2.5 in every 1,000 live births in Europe. It results from damage to the developing brain and adversely affects motor control. The limitations in motor control range from an inability to even hold the head erect …
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Synthesis of sphingosine analogues and evaluation of anticancer activity
No abstract available.
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In hypertension do smaller holes in arterial internal elastic lamina lead to fewer routes for myoendothelial junctions and hence less EDHF response?
The work presented in this thesis describes the influence of the endothelium on smooth muscle cells, and how the structure of the internal elastic lamina (IEL) affects this relationship in mesenteric and saphenous arteries. This was enabled by the study of functional and confocal microscopy dye …
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Seasonal variation in fitness levels of professional youth footballers over a competitive season
The use of applied sports science in soccer is growing rapidly. Fitness testing and monitoring of training intensities are now becoming common place in the modern game. Anecdotally it appears that fitness may decrease over the season after initially being high following pre-season. While field …
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Myosin and electrophysiological heterogeneity in cardiac muscle
Abstract available p. v-vii
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Diet, hydration, lifestyle and training practices of elite Kenyan endurance runners
Since the emergence of Kenyan endurance runners on the world stage at the 1968 Mexico Olympics, where they won 8 medals ranging from 400 m relay to the 10 000 m, Kenyan success has grown year on year. The staggering success of a country that compromises just 0.5 % of the world population has …
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Human aldosterone synthase and 11[beta]-hydroxylase: studies on the relationship of structure and function and their clinical implications
Abnormalities in adrenal steroid production have been implicated in certain forms of hypertension. Mutations in the CYP11B1 gene which result in complete loss of 11-hydroxylase function cause 11-hydroxylase deficiency and hypertension due to abnormally high levels of mineralocorticoid, DOC. …
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The relationship between repolarisation alternans and the production of ventricular arrhythmia in heart failure
… was developed and the transmural electrophysiology of intact rabbit ventricle was characterised using optical imaging techniques. This revealed transmural gradients of repolarisation in intact rabbit myocardium, which appeared to be influenced by electrotonic load, rather than purely …
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Interactions between potassium channels and serotonin in pulmonary arterial hypertension
Pulmonary arterial hypertension (PAH) is a progressive disease which results from increases in mean pulmonary artery pressure and pulmonary vascular resistance. If untreated it leads to right ventricular failure and death. 5-Hydroxytryptamine (5-HT) has been implicated in the disease process and is …
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The effects of increased Plp1 gene dosage on expression and processing of myelin proteins
Mutations in proteolipid protein 1 (PLP1), an X-linked gene causes Pelizaeus-Merzbacher disease (PMD) in humans. The most frequent cause of PMD is the duplication of PLP1, which encodes the major myelin membrane protein of the human CNS. The #66 transgenic mice with extra copies of the wild type …
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Expression and function of drug transporters in primitive CML cells
Chronic myeloid leukaemia (CML) is a stem cell (SC) disorder initiated by the reciprocal translocation between chromosome 9 and 22, giving rise to the Philadelphia (Ph) chromosome and the resulting expression of the oncogenic fusion protein BCR-ABL. The current first line of treatment is imatinib …
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