Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 191 for “"QH301 Biology"”.
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A study of the impacts of fragmentation on the North Kent grazing marshes landscape characteristics, features and vegetation communities
Coastal grazing marshes are low lying wet grasslands, which have been reclaimed from tidal saltmarsh. They are drained by a series of ditches and dykes, which together with the grasslands provide a range of fresh and brackish wetland habitats favourable to a wide range of plant, invertebrate, bird …
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The impact of silver nanoparticles on plant physiology
Engineered nanoparticles (ENPs) are increasingly being exploited in a whole range of applications and products due to their novel physicochemistry. Hence it is inevitable that ENPs will enter the environment at an increasing rate over the coming years. The consequential impact following interaction …
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Application of molecular mechanics polarization to fragment based drug design.
Polarization is a term that is often excluded from almost all virtual screening. Polarizability helps explain interactions between nonpolar atoms and electrically charged species. When studying fragments in FBDD these minor interactions could have large effect in changing how well a ligand will …
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Production of Dimethyl Sulphide (DMS) by Scleractinian Coral during Aerial Exposure – Effect of Temperature and Light
In this thesis I investigated how rates of DMS production in three Scleractinian corals were affected by both aerial exposure and different light and temperature regimes. Coral specimens were acclimated over a 1 month period prior to data collection. Gas samples were collected from corals both …
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Cell biology of settlement and adhesion processes of biofouling algae
… in this thesis was to investigate the cell biology behind the settlement and adhesion processes of biofouling algae. Using the fluorescent dye FM 1-43 in Ulva zoospores to follow membrane recycling, rapid mass membrane retrieval of FM 1-43-labelled plasma membrane was found to occur to an …
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The Role of the C-terminus in Bacillus subtilis inorganic pyrophosphatase activity
Inorganic pyrophosphatases hydrolyse inorganic pyrophosphate ensuring that the pool of phosphate is continuously available in a cell for subsequent metabolic reactions. Bacillus subtilis PPase is the first member of the Family II of PPases, unique not only in terms of physical/biochemical …
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An improved microarray image analysis architecture using mathematical morphology
DNA microarrays are now widely used to measure gene expression levels of healthy and cancerous cells. To allow further experiment for drug development to treat cancer, colour intensity from images of microarray spots need to be extracted as accurate as possible. The intensity extraction requires …
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Sir epidemic and predator - prey models of fractional-order
Recently, many deterministic mathematical models such as ordinary differential equations have been extended to fractional models, which are transformed using fractional differential equations. It was believed that these fractional models are more realistic to represent the daily life phenomena. The …
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Effects of carbohydrates on iron metabolism in intestinal and liver cells
Iron deficiency and excess are worldwide public health problems. Studies suggest that carbohydrates such as fructose, and oligo-and polysaccharides (prebiotics), increase iron bioavailability, but results are inconclusive. There is also interest in whether iron and fructose contribute to the …
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A cytochemical and immunological study of tumour cells
Initial tumour growth was found to be exponential following intraperitoneal inoculation of 5 x 106 Ehrlich ascites tumour cells into male BALB/c mice. After three days of this pattern the rate of growth became noticeably retarded and after 12 days a plateau phase ensued. The reduced growth rate was …
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An investigation into novel molecules involved in the development of the nervous system of Drosophila melanogaster
A major facet of nervous system development entails the projection of axons from neuronal cell bodies towards synaptic partners, such as other neurons or muscles. This process, referred to as “axon guidance,” relies upon receptors on axons detecting secreted or membrane-associated guidance cues …
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The characterisation of a recombinant cytosolic shuttle based on ricin toxin
Cytosolic access is rate limiting for potential therapeutics such as antisense agents. In nature, several entities deliver macromolecules to the cytosol, one example being ricin toxin (RT). In this thesis, a cytosolic drug delivery system based upon attenuated RT was characterised. The …
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Atlantic salmon dynamics in the Foyle catchment (Ireland), a Bayesian approach
Population dynamics is the study of the abundance of a species at different life stages of a species, the interactions between these life stages and sometimes the interactions with other species. Stage-structured modelling is a popular approach for population dynamics studies. This approach …
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A neurophysiological and proteomic study of cognitive enhancing strategies
Improving cognitive function is a growing area of interest for pharmaceutical companies. With an ageing population, cognitive decline is becoming a greater problem. Understanding the physiological effects of nootropic drugs and the changes that occur during cognitive enhancement will enable the …
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Targeted delivery of biological agents
Biological agents, including peptides and gene delivery systems (recombinant adenoviral vectors), suffer from a relative lack of native targeting capacity. Improvement of their targeting capacity could significantly increase the efficiency of these agents to provide therapeutic effects. Selective …
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Regulation of membrane fusion by Tlg2p & Vps45p through the endosomal system of Saccharomyces cerevisiae
SNARE proteins are essential components of the machinery that facilitates membrane fusion in eukaryotic cells. SNARE proteins are subject to multiple levels of regulation, one of which is imbedded in the syntaxin (Qa-SNARE) molecule. It has been demonstrated that some syntaxins adopt a closed …
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Glutathione metabolism of Plasmodium falciparum
Apicomplexan parasites of the genus Plasmodium are the causative agent of malaria, one of the most prevalent infectious diseases worldwide. Five different Plasmodium species can cause malaria in humans, leading to a total of approximately 500 million cases each year and of these, P. falciparum …
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SNARE specificity in membrane protein traffic
Recent findings indicate that there is a role for SNAREs in ion channel regulation. With the discovery of the vesicle trafficking SNARE protein NtSYP121 came the development of the predicted cytosolic domain fragment of the protein. This Sp2 fragment was found in studies to block the responses of …
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Contribution of the DNA binding domain of p53 to regulation of its stability
Tumour suppressor p53 is frequently mutated in cancers. While wild type p53 is normally a rapidly degraded protein, mutant forms of p53 are stabilised and accumulate to high levels in tumour cells. Several studies have shown that mutant p53 acquires oncogenic properties and actively contributes to …
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