Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 191 for “"QH301 Biology"”.
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An improved microarray image analysis architecture using mathematical morphology
DNA microarrays are now widely used to measure gene expression levels of healthy and cancerous cells. To allow further experiment for drug development to treat cancer, colour intensity from images of microarray spots need to be extracted as accurate as possible. The intensity extraction requires …
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Sir epidemic and predator - prey models of fractional-order
Recently, many deterministic mathematical models such as ordinary differential equations have been extended to fractional models, which are transformed using fractional differential equations. It was believed that these fractional models are more realistic to represent the daily life phenomena. The …
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Effects of carbohydrates on iron metabolism in intestinal and liver cells
Iron deficiency and excess are worldwide public health problems. Studies suggest that carbohydrates such as fructose, and oligo-and polysaccharides (prebiotics), increase iron bioavailability, but results are inconclusive. There is also interest in whether iron and fructose contribute to the …
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A cytochemical and immunological study of tumour cells
Initial tumour growth was found to be exponential following intraperitoneal inoculation of 5 x 106 Ehrlich ascites tumour cells into male BALB/c mice. After three days of this pattern the rate of growth became noticeably retarded and after 12 days a plateau phase ensued. The reduced growth rate was …
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An investigation into novel molecules involved in the development of the nervous system of Drosophila melanogaster
A major facet of nervous system development entails the projection of axons from neuronal cell bodies towards synaptic partners, such as other neurons or muscles. This process, referred to as “axon guidance,” relies upon receptors on axons detecting secreted or membrane-associated guidance cues …
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The characterisation of a recombinant cytosolic shuttle based on ricin toxin
Cytosolic access is rate limiting for potential therapeutics such as antisense agents. In nature, several entities deliver macromolecules to the cytosol, one example being ricin toxin (RT). In this thesis, a cytosolic drug delivery system based upon attenuated RT was characterised. The …
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A study of the impacts of fragmentation on the North Kent grazing marshes landscape characteristics, features and vegetation communities
Coastal grazing marshes are low lying wet grasslands, which have been reclaimed from tidal saltmarsh. They are drained by a series of ditches and dykes, which together with the grasslands provide a range of fresh and brackish wetland habitats favourable to a wide range of plant, invertebrate, bird …
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Atlantic salmon dynamics in the Foyle catchment (Ireland), a Bayesian approach
Population dynamics is the study of the abundance of a species at different life stages of a species, the interactions between these life stages and sometimes the interactions with other species. Stage-structured modelling is a popular approach for population dynamics studies. This approach …
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A neurophysiological and proteomic study of cognitive enhancing strategies
Improving cognitive function is a growing area of interest for pharmaceutical companies. With an ageing population, cognitive decline is becoming a greater problem. Understanding the physiological effects of nootropic drugs and the changes that occur during cognitive enhancement will enable the …
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Targeted delivery of biological agents
Biological agents, including peptides and gene delivery systems (recombinant adenoviral vectors), suffer from a relative lack of native targeting capacity. Improvement of their targeting capacity could significantly increase the efficiency of these agents to provide therapeutic effects. Selective …
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Regulation of membrane fusion by Tlg2p & Vps45p through the endosomal system of Saccharomyces cerevisiae
SNARE proteins are essential components of the machinery that facilitates membrane fusion in eukaryotic cells. SNARE proteins are subject to multiple levels of regulation, one of which is imbedded in the syntaxin (Qa-SNARE) molecule. It has been demonstrated that some syntaxins adopt a closed …
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SNARE specificity in membrane protein traffic
Recent findings indicate that there is a role for SNAREs in ion channel regulation. With the discovery of the vesicle trafficking SNARE protein NtSYP121 came the development of the predicted cytosolic domain fragment of the protein. This Sp2 fragment was found in studies to block the responses of …
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Glutathione metabolism of Plasmodium falciparum
Apicomplexan parasites of the genus Plasmodium are the causative agent of malaria, one of the most prevalent infectious diseases worldwide. Five different Plasmodium species can cause malaria in humans, leading to a total of approximately 500 million cases each year and of these, P. falciparum …
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Contribution of the DNA binding domain of p53 to regulation of its stability
Tumour suppressor p53 is frequently mutated in cancers. While wild type p53 is normally a rapidly degraded protein, mutant forms of p53 are stabilised and accumulate to high levels in tumour cells. Several studies have shown that mutant p53 acquires oncogenic properties and actively contributes to …
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The impact of heterogeneity in stomatal anatomical characters on stomatal function and physiology in wheat
Factors affecting food insecurity include the effects of climate change, losses of agricultural land to urbanization and increasing competition for non-food uses of crops. Stomatal anatomical characteristics including stomatal denFactors affecting food insecurity include the effects of climate …
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Ecology and biogeochemistry of fluvial microphytobenthic communities on soft sediments
Freshwater ecosystems are the link between the terrestrial and the marine biomes. Terrestrially-derived nutrients travel through, and are transformed within these ecosystems, outflowing eventually to the sea. A major player in small rivers are microphytobenthic (MPB) communities - groups of algae, …
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Insight into G Protein-Coupled Receptors through Molecular Dynamics Simulations
In recent decades, technological advancement has been increasing extremely rapidly and this allowed to open the way to wide computational approaches able to guide and support the experimental work of biological sciences. Currently, it is possible to model the behaviour of chemical systems and reach …
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Understanding and Targeting the FGF-2/S6K2 Signal Pathway in Small Cell Lung Cancer Towards the Development of Novel Anti-Cancer Treatments.
Small Cell Lung Cancer (SCLC) cells activate a signal pathway in response to chemotherapy, as a result the cancer rapidly develops chemoresistance. Since the late 1980’s SCLC has a poor prognosis with a 5 year survival rate of only 5%, highlighting the need for novel therapeutic intervention. This …
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Development of Serial Crystallography Methods for Synchrotrons and X-ray Free-Electron Lasers
X-ray crystallography of proteins is a well-established method to identify atomic level molecular arrangement, however when exposing crystalline proteins to ionising radiation, damage can occur to their overall molecular structure (global damage), while solvated electrons generated by X-rays can …
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The impacts of climate change on freshwater microbes: Insights from the field to the laboratory
Global climate change, and in particular, global warming is currently one of the greatest threats to freshwater biodiversity. The microbial diversity within freshwaters is phylogenetically and functionally diverse. Yet, the impacts of warming on these complex communities are largely unknown. To …
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