Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 217 for “"Q Science (General)"”.
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Two stages hybrid model of fuzzy linear regression with support vector machines for colorectal cancer
… cancer patients who received treatment in general hospital with twenty five independent variables with different combination of variable types were considered to find the best models to predict the tumor size of CRC. The main objective of this study is to determine the best model to …
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Immunological and biosynthetic studies of the human pyruvate dehydrogenase complex
… and pE3-E2 cloned into the same plasmid. The general findings of this study were as follows: firstly, comparing the levels of expression of each precursor to its mature form through small-scale protein inductions in E. coli at different temperatures, it was observed that both types of …
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Purine transport in plasmodium falciparum
Purine transport in malaria parasites has become an important potential drug target because the malaria parasite is unable to synthesis purine de novo and has to salvage it from the host milieu through transporter(s). Knowledge of the number, selectivity and kinetic parameters of the transporters …
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Characterisation of quiescin-sulfhydryl oxidase and nematode astacin mutants using functional studies in caenorhabditis elegans.
Nematodes, both free-living and parasitic, are dependant upon their Extra Cellular Matrix (ECM) for multiple aspects of functionality. Two distinct ECMs are present in Caenorhabditis elegans, the basement membrane and the cuticle. The cuticle of C. elegans, like other nematodes is composed largely …
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Biochemical investigation of phosphodiesterase type IV post-translational modification, cellular localisation and interaction with associated binding proteins
cAMP is a secondary messenger that is involved in a variety of signalling pathways through its effectors including EPAC, PKA and ion channels. cAMP signalling regulates processes such as memory, muscle contraction and inflammatory responses. PDE enzymes offer a mechanism to negatively regulate …
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Development and application of a novel method to determine large very low density lipoprotein (VLDL1) kinetics
High concentrations of large very low density lipoproteins (VLDL1) give rise to atherogenic dyslipidaemia, which is usually associated with insulin resistant conditions (e.g. obesity) and increases the risk for cardiovascular disease (CVD). Isotopic tracer methods for determining VLDL1 kinetics are …
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Analysis of cyclin dependent kinases in Leishmania
The results obtained from the experiments presented in this study aimed to further explore the role of cyclin dependent kinases and cyclins in the protozoan parasite Leishmania major. Cdks in kinetoplastids, CRKs, are the key regulators that allow cells to progress through different cell cycle …
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An investigation into dystroglycan deficiency in fibroblasts and a role for dystroglycan in cytokinesis
Dystroglycan is a heterodimeric cell adhesion molecule consisting of alpha and beta subunits, which links the actin cytoskeleton to the extracellular matrix. Dystroglycan has an important structural role and is integral for maintaining tissue integrity, but new avenues have research have implicated …
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Kynurenines in neurological disorders
The kynurenine pathway is thought to be involved in neurological disorders but its precise role and the mechanisms involved have yet to be established. Tryptophan can be metabolised via this pathway to produce the neurotoxic N-methyl-D-aspartate (NMDA) receptor agonist, quinolinic acid (QUIN), and …
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Amino acid transporters & amino acid metabolism in Trypanosoma brucei brucei
The development of new drugs against Human African Trypanosomiasis is much needed due to toxicity, efficacy and availability problems with current drug treatments for this resurgent parasitic disease. Delivery of drugs into cells is an important determinant of therapeutic efficacy of drugs. An …
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Lipoic acid protein ligases in Plasmodium spp.
Protozoan parasites of the genus Plasmodium are the causative agent of malaria. The four human pathogenic species infect more than 500 million people each year, causing the death of at least 1 million people. The most severe form of human malaria is caused by P. falciparum, which is responsible for …
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Modelling sea surface temperature using generalized additive models for location scale and shape by boosting with autocorrelation
… data lead to incomplete information over time. Generalized additive models by boosting with location scale and shape (gamboostLSS) can be applied to overcome this problem. Moreover, they also deal with sparsity, irregular peaks, and autocorrelation in the data. We propose in this thesis extended …
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The effects of growth conditions on the elemental and biochemical composition of the diatom Thalassiosira weissflogii and the haptophyte Emiliania huxleyi
A change in environmental conditions often leads to changes of physiology and biochemical composition of microalgae. Temperature and light intensity are important environmental factors regulating the growth of microalgae. In this study, the elemental and biochemical composition were measured in 2 …
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Intracellular peptide library screening to derive inhibitors of Parkinson's disease associated α-synuclein aggregation
… that the PCA strategy can be used as a generalised method for deriving peptide antagonists of α-syn aggregation, together with a new region; α-syn45-54 as an inhibitor target and produced a peptide inhibitor expected to provide a scaffold for future drug candidates to slow or even …
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Application of whole-cell biosensor for the impact of crude oil exploration on the environment of the Niger Delta
The discovery of crude oil in exportable quantities in Nigeria was greeted with overwhelming ovation and high expectations in terms of the wealth generation possibilities and economic growth for the region. However, 5 decades onwards, the Niger-delta terrain and its people have become disenchanted …
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When disaster strikes: human responses to wildfires and evacuation in the south of France and Australia
… an understanding of behaviours that may be generalised or regionally-specific • using the combined data to create regression models that predict behavioural outcomes such as the decision to evacuate and evacuation delay times • considering the potential for regression and evacuation models …
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Landing behaviour of the host seeking malaria vector anopheles coluzzii in response to host associated cues
v ABSTRACT Female mosquitoes of the genus Anopheles transmit the parasites responsible for malaria, one of the most serious vector-borne diseases, which affects one-fifth of the world population. Current malaria prevention relies heavily on vector control interventions, which are most effective and …
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Towards realising multimodal robots
Evolutionary Algorithms (EAs) have been applied in co-evolutionary robotics over the last quarter century. They simultaneously generate the robot body morphology and controller algorithm through artificial evolution. However, the literature shows that in this area, it is still not possible to …
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Generating datasets for anomaly-based intrusion detection systems in IoT networks
Over the past few years, we have witnessed the emergence of Internet of Things (IoT) networks that bring significant benefits to citizens, society, and industry. However, their heterogeneous and resource-constrained nature makes them vulnerable to a wide range of threats and an attractive target to …
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