Global ETD Search
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Showing 1 to 4 of 4 for “"Pyruvate dehydrogenase kinase 4"”.
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Regulation of Pyruvate Dehydrogenase Kinase 4 by Thyroid Hormone / Role of Peroxisome Proliferator Activated Receptor Gamma Coactivator-1 alpha and Ccaat Enhancer Binding Protein
<p>Pyruvate dehydrogenase kinase 4 (PDK4) regulates pyruvate oxidation through the phosphorylation and inhibition of the pyruvate dehydrogenase complex (PDC). The PDC catalyzes the conversion of pyruvate to acetyl-CoA and it is an important control point in glucose and pyruvate metabolism. Previous …
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Characterizing PDK4 and PKC-Theta in Pancreatic Cancer and Cachexia
… abnormalities and systemic inflammation. Pyruvate Dehydrogenase Kinase 4 (PDK4) is upregulated in the skeletal muscles of many cancer cachexia models and has been shown to drive muscle wasting in some conditions. We show that despite being upregulated in an orthotopic mouse model of PDAC …
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Chickens Selected for High Body Weight Show Relative Impairment in Fatty Acid Oxidation Efficiency and Metabolic Flexibility in Skeletal Muscle and White Adipose Tissue
… and is influenced by activity of the pyruvate dehydrogenase complex (PDC). The Virginia lines of chickens are a unique model of anorexia and obesity that have resulted from 56 generations of artificial selection for high (HWS) or low (LWS) juvenile body weight. We hypothesized that …
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Carnosine’s inhibitory effect on glioblastoma cell growth is independent of its cleavage
… the amino acid also increased expression of pyruvate dehydrogenase kinase 4 (PDK4) mRNA expression. These observations pointed towards the possibility that carnosine could just be a vehicle, delivering L-histidine to target cells, and that release of the imidazole-containing amino acid is …