Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 21 for “"Pyruvate Dehydrogenase Complex"”.
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Immunological and biosynthetic studies of the human pyruvate dehydrogenase complex
The human pyruvate dehydrogenase multi-enzyme complex (PDC) catalyses the oxidative decarboxylation of pyruvate, transferring the resultant acetyl group to coenzyme A. It belongs to the family of 2-oxoacid dehydrogenase complexes that includes the 2-oxoglutarate dehydrogenase (OGDC) and …
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Structure and Molecular Biology of the Pyruvate Dehydrogenase Complex from Bacillus stearothermophilus
The pyruvate dehydrogenase multienzyme complex (PDHC) from the thennophilic, Gram-positive bacterium Bacillus stearothermophilus is assembled around a core of 60 copies of the dihydrolipoamide acetyltransferase (E2p) component, organized with icosahedral symmetry. The peripheral subunits, attached …
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Properties of a newly characterized protein of the bovine kidney pyruvate dehydrogenase complex
Call number: LD2668 .T4 1985 J54
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Properties of a newly characterized protein of the bovine kidney pyruvate dehydrogenase complex
Call number: LD2668 .T4 1985 J54
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Analysis of genetic mutations using a recombinant model of the mammalian pyruvate dehydrogenase complex
The human mitochondrial pyruvate dehydrogenase complex (PDC) is a vital metabolic assembly that controls the key committed step in aerobic carbohydrate utilisation and energy production and as such is responsible for overall glucose homeostasis in man. PDC, particularly from prokaryotic sources, …
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The study of two genes involved in the maintenance of intracellular redox potentials in Thiobacillus ferrooxidans
… regions of homology to the genes of the pyruvate dehydrogenase complex. Synthesis of proteins corresponding to the T. ferrooxidans citrate synthase (43 kDa) and ϒ-glutamylcysteine synthetase (49 kDa) enzymes were confirmed using an E. coli-derived in vitro transcription/translation …
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Molecular Analyses of the Soybean Glabrous Mutation (P1) and of Transgenic Lines Designed to Modify Seed Composition
… project aimed to reduce the expression of the pyruvate dehydrogenase kinase (PDHK) gene by RNAi. The PDHK gene regulates the activity of the pyruvate dehydrogenase complex (PDC) by reversible phosphorylation of the E1alpha subunit of the PDC. The PDC catalyzes the oxidative decarboxylation of …
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The intersection of metabolism and oxygen in T cell function and anti-tumour immunity
… that glutarate controls the activity of the pyruvate dehydrogenase complex (PDHc) via the post-translational modification glutarylation. The final results chapter, Chapter VI, focuses on the role of molecular oxygen as a regulator of T cell activation and metabolic reprogramming. This chapter …
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The role of pyruvate dehydrogenase kinase in glucose and ketone body metabolism
The expression of pyruvate dehydrogenase kinase (PDK) 2 and 4 are increased in the fasted state to inactivate the pyruvate dehydrogenase complex (PDC) by phosphorylation to conserve substrates for glucose production. To assess the importance of PDK2 and PDK4 in regulation of the PDC to maintain …
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Chickens Selected for High Body Weight Show Relative Impairment in Fatty Acid Oxidation Efficiency and Metabolic Flexibility in Skeletal Muscle and White Adipose Tissue
… and is influenced by activity of the pyruvate dehydrogenase complex (PDC). The Virginia lines of chickens are a unique model of anorexia and obesity that have resulted from 56 generations of artificial selection for high (HWS) or low (LWS) juvenile body weight. We hypothesized that …
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Characterization of an assay of insulin mediator activity on pyruvate dehydrogenase in liver tissue and its application in the study of the insulin resistant obese Zucker rat
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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Metabolic flux analysis of Escherichia coli MG1655 under octanoic acid (C8) stress
… acid (TCA) cycle, pentose phosphate pathway, pyruvate node, alpha-ketoglutarate node and oxaloacetate node changed. By comparing the metabolic flux maps of E. coli MG1655 grown at different conditions, pathways that have flux change under stress were identified. Inhibition effect for several …
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Cell-Type Specific Requirement for Pyruvate Dehydrogenase in Hematopoiesis and Leukemia Development
Pages i-xii are misnumbered as pages ii-xiii, and page 142 is misnumbered as page 121.
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Toxicity mechanism of anthropogenic water contaminants: drinking water disinfection by-products (haloacetic acids) and particle associated contaminants from sealcoats (polyaromatic hydrocarbons) in lake sediments
… inhibitors of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) where, di-, and triHAAs were weaker inhibitors. MonoHAAs greatly reduced the ATP contents of the cells. Unlike monoHAAs, triHAAs increased the cellular ATP levels as compared to the negative controls. Exogenous pyruvate …
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Xylitol Production From D-Xylose by Facultative Anaerobic Bacteria
… the difference in xylose reductase and xylitol dehydrogenase activity was highest at 24 h, whereas for cell cultures that were grown in gluconate and xylose, the difference in the reductase and dehydrogenase activities was highest at 12 h after xylose addition. The NAD+ dependent xylitol …
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The Role of Pyruvate Dehydrogenase in Cell Growth
… glucose oxidation, indicating activity of pyruvate dehydrognase (PDH), which gates entry of glucose derived carbon into the tricarboxylic acid (TCA) cycle. To test whether cells require glucose oxidation for proliferation, the work in this thesis establishes a model wherein PDH activity is …
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Phosphorylation of Skeletal Muscle Pyruvate Dehydrogenase Phosphatase in Response to Insulin Stimulation
Pyruvate dehydrogenase phosphatase (PDP) regulates carbohydrate oxidation through the pyruvate dehydrogenase (PDH) complex. PDP activates PDH, enabling increased carbohydrate flux towards oxidative energy production. In culture myoblasts, both PDP1 and PDP2 undergo covalent activation in response …
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Regulation of Pyruvate Dehydrogenase Kinase 4 by Thyroid Hormone / Role of Peroxisome Proliferator Activated Receptor Gamma Coactivator-1 alpha and Ccaat Enhancer Binding Protein
<p>Pyruvate dehydrogenase kinase 4 (PDK4) regulates pyruvate oxidation through the phosphorylation and inhibition of the pyruvate dehydrogenase complex (PDC). The PDC catalyzes the conversion of pyruvate to acetyl-CoA and it is an important control point in glucose and pyruvate metabolism. Previous …
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TUMOR PROMOTING FUNCTIONS FOR THE METABOLIC REGULATOR SIRT5
… by targeting glyceraldehyde 3-phosphate dehydrogenase (GAPDH), pyruvate kinase M2 (PKM2), pyruvate dehydrogenase complex (PDH), isocitrate dehydrogenase 2 (IDH2) and succinate dehydrogenase (SDH). SIRT5 also controls glutamine metabolism by targeting glutaminase (GLS), and fatty acid …
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