Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"Pyrrolopyrimidine"”.
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THE DEVELOPMENT OF PYRROLOPYRIMIDINE LIBRARIES
This thesis describes the development of protocols for the preparation of both pyrrolo[1,2-c]pyrimidine and pyrrolo[1,2-c]pyrimidin-5(4aH)-one libraries. These sequences were used to synthesise analogs, which will be examined for their kinase inhibitory levels. In Chapter One, a brief overview of …
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The Discovery and Development of Thienopyrimidines as Inhibitors of Helicobacter pylori
… scaffolds with improved ADME properties. The pyrrolopyrimidine 56 emerged with good anti-H. pylori activity, an improved solubility and is less bound to human plasma protein. Lead optimization efforts are ongoing, to realize proof of concept of this series of compounds in the in vivo efficacy …
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Structural examination of trypanosomatid tubulin-binding cofactors and pteridine reductase 1 inhibition
… applied to generate ligand-binding profiles of pyrrolopyrimidine derivatives. Several interesting binding features were identified from the 24 ligand complex structures obtained. These include the discovery of two covalent inhibitors, confirming the reactivity of a non-conserved active site …
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Synthesis Of Substituted Pyrrolo[2,3-D]Pyrimidines As Microtubule-Binding Agents and HSP90 Inhibitors
An introduction, background and recent advances in the areas of microtubule-binding agents and heat shock protein 90 (HSP90) inhibitors as anticancer agents are briefly reviewed. The work in this dissertation is centered on the synthesis of substituted pyrrolo[2, 3-d]pyrimidines as potential …