Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"Pyrones"”.
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The arylation of 2-pyrones and related heterocycles
2-Pyrones, and related heterocycles such as 2-pyridones, 2-coumarins and 2- quinolones, are useful model substrates to test a novel methodology due to their varied chemical properties. In addition, these moieties possess broad spectrum biological activity. Chapter 1 provides a review of C–H …
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Developing green processes for the conversion of biobased materials into pyrones
… chapter we developed a methodology to generate -pyrones. This moiety was formed by a [3+3] reaction between a 1,3 dicarbonyl and dihaloacryloyl chloride. Bicyclic -pyrones could be transformed into 5-hydroxychomones by aromatization in good yields.</p> <p>In the third chapter, we found new …
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Direct arylation of 2-pyrones, coumarins, 2-pyridinones and 2-quinolones
… 1 involves a discussion of the prevalence of 2-pyrones and 2-pyridinones and their corresponding analogues in naturally occurring biologically active compounds. We review their chemical and biosynthesis, as well further elaboration of the core compounds. The mechanism of traditional …
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Synthesis, Characterization and Cellular Uptake of Magnesium Complexes of Pyrones and Amino Acids
… utilizing short-chain peptides (di- and tri-), pyrones, and amino acids. There is further emphasis placed on determining the in vitro uptake of all produced complexes. This work aims to mitigate the shortcomings of current magnesium supplements and better illustrate an understanding of the …
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Operation Hot Sandwich: Incorporating pyrones in [4 + 2] cycloaddition reactions to prepare thermorubin
… were successfully used to insert 15 different pyrones esters and amides into an aromatic system as a dieneophile or a 2-electron component. Modification of the electron-donor, the 4 -electron sulfoxide diene, was also attempted and proved to be somewhat effective. After attempts to use single …
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Towards the total synthesis of Phacelocarpus-2-pyrone A: Novel 2-pyrone chemistry
… for the synthesis of functionalised 2-pyrones. Initial studies focused on the synthesis of the natural product and the applications of Pd-catalysed cross-coupling reactions using the interesting palladium catalyst, CatCat. Key findings in the studies towards the natural product include: …
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Novel Conjugate Additions and Cyclizations on Multiyne Systems
… 1 provides a novel route for the synthesis of 4-pyrones with broader substrate scope and functional group tolerance. The strategy relies on an initial 1,4-addition of piperidine, followed by a nitrogen assisted 6-endo-dig cyclization and hydrolysis. Further studies with numerous propargylic and …
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Palladium and manganese catalysis in C-H activation
… methods involving the C-H activation of 2-pyrones and 2-coumarins. The cyclisation of 2-pyrones and 2-coumarins via double C-H activation is described in Chapter 2 of this thesis. The synthesis of a library of 2-pyrone and 2-coumarin substrates was achieved using this methodology. Excellent …
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Isolation and Structure Elucidation of Anticancer and Antimalarial Natural Products
… order: five new antimalarial 5,6-dihydro-𝛼-pyrones and six bicyclic tetrahydro-𝛼-pyrone derivatives from Cryptocarya rigidifolia (Lauraceae); two new and five known antiproliferative lignans from Cleistanthus boivinianus (Phyllanthaceae); two new and two known antiproliferative …
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Design, Chemical Synthesis and Biological Evaluation of Potential New Antiviral Agents
… with recently studied antibacterial natural pyrones, the synthetic molecules showing the lowest values of cytotoxicity were investigated in the inhibition of bacterial strains. Some tested compounds have shown a good activity and selectivity against Gram(+) bacteria.
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Total Synthesis of the Unique Pederin Family Member Psymberin & Chemical Studies Toward Saliniketal Family Members: Saliniketal a, Salinisporamycin and Rifsaliniketal
This manuscript consists of six chapters. The first four chapters involve the psymberin/irciniastatin A project. Psymberin was isolated from a psammoncinal sponge possessing an unprecedented differential cytotoxicity profile, whereas irciniasatin A was isolated from the marine sponge Ircinia ramose …