Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 7 of 7 for “"Pyroglutamic acid"”.
-
A New Synthesis of enantiopure C-3-substituted Glutamates by Utilization of Ortho Ester protected (S)-Pyroglutamic acid
… the starting material, non-racemic (S)-pyroglutamic acid, was converted to the corresponding oxetane ester via a DCC-mediated esterification. The latter was N-protected to provide N-acceptor substituted pyroglutamic acid oxetane esters (Acceptor=Boc,Cbz,CO2Me). After rearrangement with …
-
Entwicklung von Carben-katalysierten asymmetrischen intermolekularen Stetter-Reaktionen und direkt gekreuzter intermolekularer Benzoin-Reaktionen
… available and inexpensive chiral source L-pyroglutamic acid. This structure represents the first combination of a N-heterocyclic carbene precatalyst with a broensted acidic thioureafunction. The developed precatalyst was tested in the intermolecular benzoin condensation of benzaldehyde, …
-
De novo synthesis of high purity CD3 epsilon peptides utilizing SUMO expression system in bacteria
… specifically binds to the first 27 amino acids of CD3ε. Synthesis of CD3ε peptides proofed to be difficult due to its hydrophobic nature and presence of an N-terminal glutamine that caused many side reactions resulting in very poor peptide quality and purity. For some commercial …
-
Neue Heterazoliumsalze aus Prolin und Pyroglutaminsäure und Anwendungen in Carben-katalysierten asymmetrischen nucleophilen Acylierungen
… reactions. Triazolium salts derived from L-pyroglutamic acid in organocatalysis: In a one-pot synthesis protocol, several novel silyl-protected triazolium salts could be obtained from easily accessible L-pyroglutaminoles. The precatalysts were successfully utilised in the first asymmetric …
-
Mechanisms of Non-Enzymatic Peptide Bond Formation: Thioester and Transamidation Routes
… of glutamine t-butyl ester (Gln-tbe) into pyroglutamic acid t-butyl ester. Internal standard-based quantitative MS determined that 4.9 x 10-5 sec-1 was the rate constant for spontaneous Gln-tbe cyclization in imidazole buffer, pH 7, at 50°C, and that the enzyme glutaminyl cyclase exhibited …
-
Newly Synthesized Pyroglutamate Amide and its Neuroprotective Effect Against Neurotoxicity Induced Cell Death in Alzheimer's Disease
… that the amide bond between the MEM drug and the pyroglutamic acid may reduce the neurotoxicity that induces impairment of synaptic plasticity and neuronal damage.</p> <p>In the current study, we propose that part of the mechanism of the newly synthesized pyroglutamate amide, NSP, may promote …
-
Παράγωγα ινσουλίνης
Η ινσουλίνη είναι μία πεπτιδική ορμόνη που παράγεται από τα β-κύτταρα του παγκρέατος και παίζει ρόλο στο μεταβολισμό των σακχάρων του οργανισμού. Tα παράγωγα της ινσουλίνης έχουν σχεδιασθεί ώστε να διατηρούν δομικά χαρακτηριστικά απαραίτητα για τη βιολογική δράση του μορίου. Τα παράγωγα αυτής …