Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 26 for “"Pyrimethamine"”.
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Efficacy of sulfadoxine-pyrimethamine with and without artesunate for the treatment of uncomplicated malaria in Mozambique : a randomised controlled trial
… artesunate (AS) in combination with sulfadoxine-pyrimethamine (SP) is recommended by the World Health Organisation (WHO). Mozambique policy-makers recommended that an ACT be implemented and studied in 2003. Therefore this RCT was conducted to compare SP monotherapy with AS, plus SP in order to …
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Evaluation of the Quality of Artemether/Lumefantrine, Sulphadoxine/Pyrimethamine and Quinine Sulphate Tablets in Public and private Health Institutions in Lusaka District
… quality of Artemether/Lumefantrine, Sulphadoxine/Pyrimethamine and Quinine tablets in selected Public and Private Health Institutions in Lusaka District. A cross sectional design study was conducted using quantitative research method. 20 Public and Private Health Institutions were randomly …
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Evaluation of the Quality of Artemether/Lumefantrine, Sulphadoxine/Pyrimethamine and Quinine Sulphate Tablets in Public and private Health Institutions in Lusaka District
… quality of Artemether/Lumefantrine, Sulphadoxine/Pyrimethamine and Quinine tablets in selected Public and Private Health Institutions in Lusaka District. A cross sectional design study was conducted using quantitative research method. 20 Public and Private Health Institutions were randomly …
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Antimalarial Drug Resistance: Mechanisms of Emergence in Low-Transmission Settings
… drugs, including chloroquine and sulfadoxine-pyrimethamine, has emerged independently in South America and Colombia. In 2006, Colombia adopted Artemisinin Combination Therapies (ACTs) as front-line antimalarial treatments, and withdrew the previous frontline therapy, sulfadoxine-pyrimethamine. …
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The use of liquid-chromatography mass spectrometry for the absolute quantitation for bio-analytes: fro small molecular mass compounds towards larger molecular mass proteins
… of the small molecular mass compounds pyrimethamine/sulfamethoxypyrazine and glycopyrrolate. Moreover, also for the larger molecular mass protein cystatin C was mass spectrometry investigated for its absolute quantitation. This, by means of marker peptides. In this way, the larger …
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Malaria treatment seeking behaviour and access to artemisinin combination therapy : a case of Mushin, Lagos, Nigeria
… of malaria to chloroquine (CQ) and sulphadoxine pyrimethamine (SP). However, very little is known about malaria and treatment-seeking patterns and the use of ACTs since the adoption of the treatment policy more than 6 years ago in Nigeria.
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Joint models for nonlinear longitudinal profiles in the presence of informative censoring
… primarily to measure the efficacy of sulfadoxine-pyrimethamine (SP) and a combination of artesunate and sulfadoxine-pyrimethamine (ACT), in eliminating asexual parasites in patients. The patients enrolled in the study had uncomplicated malaria, at a time of increasing resistance to …
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Large–scale data–driven network analysis of human–plasmodium falciparum interactome: extracting essential targets and processes for malaria drug discovery
… strains, notably, to chloroquine and sulfadoxine-pyrimethamine in Africa is traced mainly to Southeast Asia where artemisinin resistance rate is increasing. Although careful surveillance to monitor the emergence and spread of artemisinin-resistant parasite strains in Africa is on-going, research …
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Synthesis, characterisation and in vitro studies of metal complexes of some selected antimalarial drugs
… trimethoprim, sulfadiazine, tetracycline and pyrimethamine have been synthesised using the following metal ions: Co(II), Cu(II), Zn(II), Mn(II), Ni(II), Pt(II), Pd(II), Co(III), Fe(III), Ru(III) and VO(II). The complexes were characterised by melting point / decomposition temperature, …
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A cost analysis of the treatment of first-line uncomplicated malaria in the Tonga district of Mpumalanga
… and mefloquine. It was found that sulfadoxinepyrimethamine was 5 times more cost-effective as first line therapy than chloroquine. Of the other modelled drugs, it was recommended that an artesunate combination should be implemented when it becomes necessary to replace …
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Effect of dihydroartemisin-piperaquine for malaria intermittent preventive treatment on dolutegravir exposure in pregnant women living with HIV
… as a promising alternative to sulfadoxine-pyrimethamine for malaria prevention in pregnancy. However, another antimalarial drug, artesunate-amodiaquine, similar to dihydroartemisininpiperaquine, was previously shown to reduce dolutegravir exposure in non-pregnant adults. Objective: To …
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Folate Status and Supplementation in the Horse
… In the third study, daily oral administration of pyrimethamine (PYR) and sulfadiazine (SDZ) for 9 wk followed by 6 wk of coadministration of either Peptidoglycan or FA was associated with a decline in folate status resulting in moderate hyperhomocysteinemia, but not clinical signs of anemia. …
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Spironucleus Vortens of the Freshwater Angelfish (Pterophyllum scalare): Growth Requirements, Chemotherapeutants, Pathogenesis and Immunity
… agents; dimetridazole, metronidazole, pyrimethamine, albendazole, fenbendazole, mebendazole, and magnesium sulfate was evaluated. The pathogenicity of S. vortens in angelfish was investigated in fish experimentally inoculated with trophozoites. This study provided information to help …
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Design and synthesis of pyrimido[4,5-b]indoles and furo[2,3-d]pyrimidines as single agents with combination chemotherapy potential or as inhibitors of tubulin or thymidylate synthase
… involving combination of sulfadiazine and pyrimethamine is limited by drug resistance and treatment failures. The thymidylate synthase‒dihydrofolate reductase enzyme is important for thymidylate synthesis in T. gondii, and hence can be targeted to treat T. gondii infection. TS is highly …
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Malaria policy and control in independent Timor-Leste: foundation, consolidation and implementation
… for falciparum malaria from sulphadoxine-pyrimethamine to artemether-lumefantrine. The formulation of this new MTP was undertaken by the MoH, WHO and other stakeholders. Lack of clear policy impeded the early implementation of the new MTP. Despite considerable achievements in malaria …
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Synthesis, pharmacological and solubility evaluation of antiplasmodial pyrido[1,2-a]benzimidazoles with cyclic and functionalized amine side chain substituents
… parasites to chloroquine and sulphadoxine-pyrimethamine, once mainstays of malaria treatment, has further set back control efforts. Recent reports of emerging resistance to ACTs, the current first-line antimalarial drugs, present an even grimmer picture in regard to future control and …
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Design and synthesis of potential antimicrobial agents
… were designed to retain the pharmcophore of pyrimethamine (2,4- diamino-5(4-chlorophenyl)-6-ethylpyrimidine), but encompassing a range of polar groups that might interact with the M. tuberculosis DHFR glycerol binding pockets. Finally, the research described in this thesis contributes to the …
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Modelling gametocytes in the presence of interval-censoring
… quintuple mutations and used sulfadoxine-pyrimethamine were estimated to experience the most prolonged duration of gametocytemia. It was also found that age, treatment and baseline asexual parasitemia influenced whether a patient would develop gametocytes.
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The efficacy and safety of artesunate suppositories in combination with other antimalarials in the treatment of severe malaria in Sudan.
… artesunate rectocaps followed by doxycycline or pyrimethamine/sulphadoxine or mefloquine resulted in clinical cure rates of 100%, 100% and 96.7% respectively. The combination with either doxycycline or pynmethamine/sulphadoxine is equally effective to that followed by mefloquine in preventing …
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