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Showing 1 to 18 of 18 for “"Pyridoxal 5' phosphate"”.
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Synthesis of 6-Deoxy-6-Amino Chitosan and applications thereof
… catalyst support was extended to a biomimetic pyridoxal 5′-phosphate (PLP) based support. Immobilised pyridoxal 5′-phosphate (PLP) was investigated as an enzyme mimic in the deamination of L-phenylalanine to phenylpyruvate.
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Influence of vitamin B-6 intake on vitamin B-6 status of lactating women and on the vitamin content of their milk: enzymatic, microbiological, and HPLC techniques
… had inadequate vitamin B-6 status. Plasma pyridoxal 5-phosphate values were significantly higher for subjects in the supplemented than in the nonsupplemented group. Pyridoxal, pyridoxamine, pyridoxine, and total vitamin B-6 concentrations in milk were higher, sometimes significantly, in the …
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Comparative enzymology of wheat germ aspartate transcarbamoylase and related studies
… were studied by reaction with phenylglyoxal and pyridoxal 5'-phosphate respectively. In each case one or more residues were found at the active site, the reaction of which showing many similarities to previous studies on the E.coli catalytic subunit. One exceptionally reactive histidyl residue …
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Plant aromatic amino acid decarboxylases: Evolutionary divergence, physiological function, structure function relationships and biochemical properties
… enzymes categorically joined through their pyridoxal 5'-phosphate (PLP) dependence and sequence homology. Extensive evolutionary divergence of this enzyme family has resulted in a selection of enzymes with stringent aromatic amino acid substrate specificities. Variations in substrate …
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Structural and Functional Studies on the Escherichia coli Inducible Lysine Decarboxylase: Linking the Acid Stress and Stringent Responses
… including a number of structurally related, pyridoxal-5′-phosphate (PLP)-dependent amino acid decarboxylases, including the glutamic acid, arginine, lysine, and ornithine decarboxylases. The decarboxylases are large multi-domain enzymes that exist as homodimers or higher-order oligomers and …
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Some Aspects of the Biochemistry of Malabsorption from the Upper Intestinal Tract
… the measurement of vitamin B6, in the form of pyridoxal-5'-phosphate (PLP), is convenient to use but further mechanisation is necessary to improve reproducibility. 182 gastrointestinal patients and 124 normals have had their serum PLP measured. Amongst normals, women had a statistically …
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Synthesis of Mycobacterial Ergothioneine biosynthetic pathway metabolites
… and purified. The last step catalyzed by EgtE, a pyridoxal 5-phosphate (PLP)-dependent β-lyase convert the S-(β-amino-β-carboxyethyl) ergothioneine sulfoxide to ergothioneine. This thesis describes the synthesis of ESH pathway enzyme substrates, with the main focus on the synthesis of the EgtE …
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Biophysical and structural studies of novel F420-dependent oxidoreductases in Mycobacterium tuberculosis
… function that are annotated as “pyridoxine 5’-phosphate (PNPOx)-like” proteins based on structural similarity: Rv2607, Rv2991, Rv1155, Rv2074, Rv3369c, Rv1875, Rv0121c. PNPOx is a flavin mononucleotide (FMN)-dependent enzyme involved in the biosynthesis of the crucial cofactor, pyridoxal 5’- …
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The effects of fatigue on glycogen, glycogen phosphorylase, and calcium uptake associated with the sarcoplasmic reticulum of rat skeletal muscle
… derived from the hydrolysis of one adenosine triphosphate (ATP) molecule. The process of SR Ca²⁺ uptake causes muscle relaxation. It has been proposed that both glycogen and glycolytic enzymes are associated with the SR membrane (SR-glycogenolytic complex). Interestingly, glycogen phosphorylase, …
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PLP-Dependent α-Oxoamine Synthases: Phylogenetic Analysis, Structural Plasticity, and Structure-Function Studies on 5-Aminolevulinate Synthase
… members of the alpha-oxoamine synthase family of pyridoxal 5'-phosphate (PLP)-dependent enzymes. The evolutionary relationships among α-oxoamine synthases representing a broad taxonomic and phylogenetic spectrum have been examined to help identify residues that may regulate substrate specificity. …
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Synthesis and applications of aminated biopolymers
… an amination strategy for the immobilisation of pyridoxal and pyridoxal 5'-phosphate (PLP) for application in non-enzymatic deamination of L-phenylalanine to phenylpyruvate. An ionic complex between PLP and Q188 was formed and successfully utilised to convert L- phenylalanine into phenylpyruvate, …
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Biochemical Studies of Aromatic Amino Acid Decarboxylases and Acetaldehyde Synthases
Pyridoxal 5'-phosphate (PLP)-dependent enzymes widely exist in most living organisms from bacteria to human. Among different types of PLP-dependent enzymes, aromatic amino acid decarboxylases play critical physiological roles because many aromatic amines are essential neurotransmitters. This …
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Biochemical studies of enzymes in insect cuticle hardening
… concerns the biochemical activities of several pyridoxal 5-phosphate (PLP)-dependent decarboxylases with most of them involved in insect cuticle hardening. Herein, we first present a detailed overview of topics in reactions and enzymes involved in insect cuticle hardening. Aspartate …
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Amino acid racemase responsible for the biosynthesis of D-aspartate and D-serine signaling molecules in Aplysia californica central nervous system
… examine the structure-function relationships of pyridoxal-5’-phosphate (PLP) dependent amino acid racemase.
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Development and Evolution of ‘Ene’-Reductases for Selective Radical Chemistry
… is applied to a different family of enzymes—pyridoxal-5’-phosphate-dependent threonine aldolases and transaminases. In broadening the versatility of biocatalytic radical chemistry, these studies demonstrate that enzymatic methods can offer new approaches to synthetic chemistry and offer …
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Homocystéine et ferritine: facteurs de risque additionnels des maladies cardiovasculaires chez la femme ménopausée
… à l'hyperhomocystémie à cause d'une carence en pyridoxal 5’-phosphate (PLP), la troisième coenzyme, et les femmes préménopausées encore plus vu leur déficience significativement supérieure (P < 0.05). Au contraire, le niveau d'homocystéine plasmatique ntotale des femmes préménopausées était deux …
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Structural studies of putative general stress and related proteins from Deinococcus radiodurans
… is identified as a FMN-binding pyridoxine 5'-phosphate oxidase (PNPOx) enzyme, as sequence homology suggests, it could play a role in detoxification and stress response through production of pyridoxal 5'-phosphate (PLP), a known scavenger of ROS. Only further characterisation and elucidation …