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Showing 1 to 20 of 22 for “"Pyridone"”.
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THREE STUDIES OF 2-PYRIDONE PHOTOADDUCT REACTIVITY
2-Pyridones such as iii undergo efficient [4+4] photocycloaddition reactions, yielding strained tricyclic cyclooctadiene structures iv and v, with functionality at every carbon. As part of a program to develop the chemistry of these complex adducts, three studies have been conducted. Halogenation …
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Control of Remote-Site Reactions by Hydrogen-Bonding in the 2-Pyridone Cyclic Dimer
Made available in DSpace on 2014-12-13T20:10:51Z (GMT). No. of bitstreams: 1 8009225.pdf: 6968844 bytes, checksum: 94cd7c9b3fb7ff8d8495bbbb6f9d1956 (MD5) Previous issue date: 1979
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SYNTHESIS AND BIOLOGICAL EVALUATION OF NATURE-INSPIRED N-HYDROXYPYRIDONES AND THEIR DERIVATIVES
… as a big challenge in the world. N-hydroxypyridone natural products have been reported to display a range if biological activities, including anti-malarial properties. However, the total synthesis of naturally occurring N-hydroxypyridones and the full scope of the biological activities of …
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The Determination of The Tautomeric Equilibrium Constant for 2-Pyridone-2-Hydroxypyridine in The Vapor Phase and Attempted Synthetic Routes to The Thiolcarboxo Group, a New Functionality
Made available in DSpace on 2014-12-10T23:01:55Z (GMT). No. of bitstreams: 1 7500306.pdf: 8064196 bytes, checksum: 54e51e8350e45ca310d67f86df76591f (MD5) Previous issue date: 1974
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Chemistry of the Degradation of Vinyl Polymers to give Carbon Fibre Precursors
… to a mixture of condensed pyrinoid and 4«pyridone sequences. Chain scission also occurs but hydrogen bonding through the 4=pyridone species prevents loss of orientation and damage to the fibre structure.
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(--)-Sparteine Mediated Asymmetric Synthesis Through Conjugate Addition of Allylic and Benzylic Organolithium Species: Development of a Methodology and Its Application Toward a Total Synthesis
… allylic organolithium species with N-protected 4-pyridones provides high yields of the corresponding 1,4-addition adduct with high enantiomeric ratios (ers). The reaction is believed to proceed through an N-acyl pyridinium salt formed on reaction of N-protected pyridone with TMSCl. An …
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Two-dimensional infrared spectroscopy of nucleic acids : application to tautomerism and DNA aptamer unfolding dynamics
… between different tautomers, using pyridone as a model system. Coupled with a laser-induced temperature-jump (T-jump), 2D IR was used to monitor rapidly exchanging tautomers in real time under physiological conditions on the nanosecond timescale. Systematically characterizing the …
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Auxiliary proton-influenced metal-mediated reactions: dioxygen activation, anion coordination, and catalysis
… coupling reactions of lithiated 6-methyl-2-pyridone with bromopyridyl derivatives. These building blocks allow the preparation of tridentate N3 ligands decorated with OH and OMe substituents flanking the fourth coordination site of a tetrahedral complex. Crystallographic characterization of …
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Supramolekulinių vamzdelinių struktūrų sintezė biciklo[3.3.1]nonano pagrindu /
… first generation cavity compound, containing 2-pyridone hydrogen bonding unit forms tubular assemblies of moderate size (up to 10 molecules in CD2Cl2) in solution. The second generation compound, containing isocytosine unit, forms very stable hydrogen bonded tetramers via self-complementariness …
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Rotational spectra and molecular structures of organometallic and organic molecules
… the keto-enol tautomers, 2-hydroxypyridine and 2-pyridone (C₅H₅NO). In addition to the tautomeric forms, pure rotational spectra of the H-bonded dimer, 2-hydroxypyridine:2-pyridinone, were also obtained. These detailed spectral investigations yielded novel and useful information about the …
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The arylation of 2-pyrones and related heterocycles
2-Pyrones, and related heterocycles such as 2-pyridones, 2-coumarins and 2- quinolones, are useful model substrates to test a novel methodology due to their varied chemical properties. In addition, these moieties possess broad spectrum biological activity. Chapter 1 provides a review of C–H …
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Studies on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and analogs
… to generate 4-fluorophenol and 1- methyl-4-pyridone. The significance of this finding with respect to neurotoxic mechanisms and design are discussed.
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Light-Mediated Dual Catalysis for C–N Bond Formation
… substituted and conformationally stable N-aryl-2-pyridones is described. This motif has emerged as a privileged scaffold in medicinal chemistry with applications in immunology and oncology, evidenced by the recent FDA approval of KRAS inhibitor sotorasib.4 This work describes the design of a …
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Spectroscopic and functional models for Hmd hydrogenase
… fragment with appended thiolate, acyl and 2-pyridone/ 2-hydroxypyridine ligands. The Fe-acyl and pyridinol derivatives are both novel to biological systems. In an effort to confirm the structure reported for Hmd, we synthesized ferrous models containing the unique acyl ligand tethered to a …
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Molecular Products from the Thermal Degradation of Selected Tobacco Components: Lignin, Tyrosine, Glutamic Acid, and Modeling of Lignin Pyrolysis using CHEMKIN Combustion Suite
… abundance were succinimide, pyrrole, 2-pyridone, and acetonitrile. On the other hand, succinimide, propiolactone, ethanol, and hydrogen cyanide were the key products under oxidative pyrolysis. CHEMKIN combustion Suite was used to model the pyrolysis of lignin and consequently, a 15 …
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Dopamine Transporter (DAT), Nicotinic Acetylcholine Receptor (nAChR), and Metabotropic Glutamate Receptor 2 (mGlu2) Irreversible Probes For Identifying Anti-Psychostimulant Therapeutics
… aim, biphenyl-carboxylic acid indanone- and pyridone-based mGlu2 PAMs were structurally modified to contain a photoreactive group (e.g., aryl azide, acetophenone) and a tag (e.g., terminal alkyne, aliphatic azide). These compounds, at present, are being subjected to mGlu2 pharmacological …
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Bicyclic Heterocyclic Systems Derived from 1, 3, 4-Trisubstituted Pyridines
… 3,4-dimethoxycarbonyl-1-methylpyrid-6-one; the pyridone was also prepared by oxidation of the quaternary salt using potassium ferricyanide. The reaction of 3,4-diethoxycarbonyl-1-methyl pyridinium iodide and 1-ethyl-3,4-dimethoxycarbonyl pyridinium iodide with sodium borohydride gave the …
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PHOTOCHEMICAL AND TITANIUM (II) MEDIATED METHODS FOR THE SYNTHESIS OF COMPLEX MOLECULAR SCAFFOLDS
… 2) utilizing a [4 + 4] photocycloaddition of 2-pyridone-enolynes to access functionally rich cyclooctanoids that are capable of further photochemical transformations into even more complex molecular scaffolds. The titanium (II) mediated Kulinkovich reaction traditionally yields cyclopropylamines …
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