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Showing 1 to 20 of 41 for “"Pyrazole"”.
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Pyridine carboxamide and pyrazole palladium(II) complexes as catalyst precursors for phenylacetylene polymerization
The objectives of this project were to synthesize and characterise pyridine carboxamide ligands and their palladium complexes and investigate their catalytic activity in the polymerization process of phenylactylene.
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C(sp2)–H Functionalizations Employing 2-Aminophenyl-1H-pyrazole as a New Removable Directing Group
<p>2-Aminophenyl-1H-pyrazole (2-APP) was discovered as a novel removable bidentate directing group for copper-mediated aerobic oxidative C(sp2)–H bond amidation and sulfonamidation bearing a wide range of sulfonamides, When Cu(OAc)2 was employed as the copper source, 1,1,3,3-tetramethylguanidine …
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The synthesis and properties of selected transition metal-pyrazole complexes and their application towards homogeneous catalysis
… of transition metal complexes containing n -pyrazole ligands. Reaction of such species with other metal complexes containing labile groups, should provide a route to the synthesis of homobimetallic or heterobimetallic complexes containing the bridging ligand.<br/><br/>This study describes the …
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Pyrazole and pyrazolyl palladium(II) and platinum(II) complexes: synthesis and in vitro evaluation as anticancer agents
The use of metallo-pharmaceuticals, such as the platinum drugs, for cancer treatment illustrates the utility of metal complexes as therapeutic agents. Platinum group metal complexes therefore offer potential as anti-tumour agents to fight cancer. This study was aimed at synthesizing and evaluating …
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Synthesis and Evaluation of New Antimicrobial Agents and Novel Organic Fluorophores
… part, to design and synthesise a new family of pyrazole ligands, their zinc(II) complexes and to evaluate their antmicrobial activity. The overall goal was to improve the antimicrobial activity of both ligand and metal salt through the formation of the corresponding zinc complex. The first …
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Development of Combinatorial Approaches Towards Selective Estrogen Receptor Modulators: Investigations of Acyclic Amides and Tetra-Substituted Pyrazoles
In addition, four basic side chain-containing pyrazoles that mimic potentially favorable orientations in the ER binding pocket were synthesized. Among the four sites for basic side chain incorporation, the C (5) piperidinylethoxy-substituted pyrazole was found to have the highest affinity and to be …
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ΜΕΛΕΤΗ ΟΞΕΙΔΩΣΗΣ ΟΞΙΜΙΝΙΚΩΝ ΚΑΙ ΙΜΙΝΙΚΩΝ ΠΑΡΑΓΩΓΩΝ ΚΑΡΒΟΝΥΛΙΚΩΝ ΕΝΩΣΕΩΝ
… WITH LEAD TETRAACETATE (LTA) RESULTED MAINLY IN PYRAZOLE- AND PYRAZOLINE - 1,2-DIOXIDES. THE EXACT TYPE OF THE N-OXIDE FORMED, DEPENDS ON THE SUBSTITUENTS ON THE 2-POSITION OF THE DIOXIME. FURTHERMORE, INFLUENCE IS ALSO EXERCISED BY ALKYL OR ARYL GROUPS ADJACENT TO THE =NOH MOIETY. DEOXYGENATION …
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The effects of phenylbutazone on a strain of fibroblasts cultivated in vitro
… 1946 by H. Stenzyl during his investigation on pyrazole and pyrazoline derivatives. Although these compounds had been studied during the previous fifty years, the pharmacological properties were only recently recognized. It has been used clinically since 1952.</p><p>Two other pharmaceutical …
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Kinetics and mechanism of iodination of 1-methylpyrazole
… in agreement with the mechanisms for aniline and pyrazole. The rate determining step is the removal of the proton from the intermediate by the buffer. However, it was found that iodine was the major iodinating species and that the iodinium ion had a much smaller effect. A qualitative discussion of …
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COMPLEXES OF GROUP 10 METALS WITH NON-CLASSICAL AND THIOETHER-FUNCTIONALIZED N-HETEROCYCLIC CARBENE LIGANDS
… In the second part, the donor strengths of pyrazole ligands has been determined and correlated to their nucleophilicities, and novel pyrazole-derived NHCs and their catalytic activities in direct arylation reactions are presented. The third part is focused on indazolin-3-ylidene ligands, …
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Synthetic and computational investigations into reaction pathways towards complex heterocyclic ring systems
… formation of 1,3a,6,6atetrahydroimidazo[4,5-c]pyrazole (a promising anti-fungal agent) from the irradiation of 2,3a,4,6a-tetraphenyl-3,3a,4,5,6,6a hexahydropyrrolo-[2,3-d]-1,2,3-triazole. One of our main aims was to synthesise novel 1,2,3,5-tetrazocines that possessed three phenyl and one …
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Design and Synthesis of Small-Molecule Protein-Protein Interaction Antagonists
… (BTT-3) that contained a 3,4-dihydro-3,4’-pyrazole core. This compound had modest biological activity when tested in a fluorescence polarization (FP) assay. The synthetic route to BTT-3 consisted of six steps. In addition, analogs of BTT-3 were made for a structure-activity study to …
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Anion-Tuning of Supramolecular Gel Properties
… compounds, chiral bisureas and urea derivatised pyrazoles are studied. The synthesized chiral bisurea compounds act as gelators in a variety of solvents. Addition of anions in the form of tetrabutyl ammonium salts was found to afford break up of the gels. Studies reveal that the rheological …
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Trichloroacetimidates As Outstanding Electrophiles for the Carbon-nitrogen, Carbon-oxygen and Carbon-carbon Bonds Formation and Synthetic Studies of Protein Phosphatase-5 (pp5) Small Molecule Inhibitors
… the utility of the this developed protocol. Pyrazoles are a group of resourceful heterocyclic compounds with their presence seen in a variety of current medications, potential illness treatments, natural products, and pharmaceutical intermediates. However, N-alkylation of these systems can be …
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Development of site-specific RNA labeling strategies to probe alternative RNA splicing
… triazoles, isoxazoles, thiophenes and pyrazoles. Attempts to install an azide moiety to the guanosine were partly successful, but the strategy was abanonded due to reaction reproducibility issues. In addition, a C-H activation strategy was not successful on installing an oxazole moiety …
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Ribonucleotide reductase in dividing cells: Purification and inhibition studies with 4-hydroxynonenal
1). The effect of temperature, P450 inhibitors (pyrazole and imidazole), sulphydryl reagents (iodoacetamide and N-ethyl maleimide) and glutathione on the activation of CCl4 in rat liver microsomes was studied. Spin trapping of CCI3', covalent binding of CCl4 to protein and CCl4-dependent MDA …
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Carbon−Hydrogen Bond Functionalization using Removable Monodentate Directing Groups
Chapter 1: 3,5-Dimethylpyrazole was employed as a mono-dentate directing group for palladium-catalyzed ortho-sp2 C−H arylation with aryl iodides. The reaction shows good functional group tolerance and outstanding selectivity for mono-ortho-arylation. Ozonolysis of ortho-arylated arylpyrazoles gave …
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I: Catalytic Direct C-H Arylation of Pyrazoles. II: Toward Modulation of Neuroplasticity with Small Molecules
… direct C-H arylation of N-substituted pyrazole compounds. The scope of the reaction and the ability to sequentially and selectively arylate specific positions on the azole core to rapidly access highly substituted pyrazoles will be discussed. Part II of this thesis addresses two …
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Studies in the synthesis of pyrimidines, pyrazoles, and pyrazolo pyrimidines. New syntheses of 1, 3 and 5 substituted pyrazolo [3, 4-d] pyrimidines, including glycosides related to naturally occurring pyrimidines, imidazoles, purines and their nucleoside derivatives.
… for the facile synthesis of various uracils, pyrazoles and pyrazolo [3,4-d] - pyrimidines with alkyl, aryl and glycosyl substituents such that the nature of the ring substituents is easily varied. To this end a number of ethoxymethylene reagents were prepared which, by reaction with primary …
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