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Showing 1 to 1 of 1 for “"Pyrazinoic acid"”.
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Synthesis and evaluation of pyrazinoic acid loaded polymeric nanoparticles in the treatment of Tuberculosis
… treat TB. PZA is a prodrug that is converted to pyrazinoic acid (POA), the active moiety that exerts its bactericidal effects in macrophages. Low therapeutic drug concentrations of PZA, severe side effects, and poor patient adherence have led to treatment failure and increasing cases of M. …