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Showing 1 to 9 of 9 for “"Pyran Ring"”.
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The Molybdenum Cofactor: Modeling the Swiss Army Knife of Metabolic Diversity
… models with, and without, the ability to form a pyran ring are described, physical parameters pertinent to pyran cyclization are analyzed, and a methanol variation of covalent hydration is observed. Together, each set of results experimentally provides evidence for MPT participation, modulated by …
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PREPARATION AND EVALUATION OF DECONSTRUCTION ANALOGS OF 7-DEOXYKALAFUNGIN AS AKT INHIBITORS
Pyranonaphthoquinone lactones have been recently found to be selective inhibitors of the serine-threonine kinase AKT/PKB. AKT/PKB plays a major role in tumorigenesis, hence these compounds have a great potential to act as anti-cancer agents. They act by a novel bioreductive alkylation mechanism of …
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The synthesis of derivatives of naturally occurring naphthalenes
… 1,3-dimethyl-1H-naphtho[2,3-c]pyran analogous to glucoside B. The first two routes describe the construction of a naphtho[ 2,3-c]pyran of the correct relative stereochemistry using the novel reactions pioneered in this Department during the synthesis of 7,9-dideoxyquinone A. In …
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Syntheses related to some naturally occurring naphthopyranquinones
The naphtho[2,3-c]pyran ring system occurs not infrequently in Nature as derivatives of the 5,10-quinone. Examples include the eleutherins, the nanaomycins and the protoaphins some of which have been shown to possess antibiotic activity. The synthesis of these natural products requires appropriate …
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Studies on the biosynthesis of the stephacidins and notoamides. Total synthesis of notoamide S and notoamide T. and Progress toward the synthesis of chrysogenamide A
… T, containing the bicyclo[2.2.2]diazaoctane ring system with the 6-hydroxy-7-prenyl indole ring of notoamide S. The synthesis of notoamide T is accomplished through a radical addition to the pyran ring of stephacidin A followed by an elimination ring opening event to provide the …
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Building a Better Model for the Molybdenum Cofactor: A New Class of Molybdenum Dithiolene Complexes
… least one dithiolene chelate, and a tricyclic pyranopterin ligand. It is present in all living things, and it participates in global carbon, nitrogen, and sulfur cycles. The exact role the ligand plays in enzymatic turnover is unknown, as crystal structures capture Moco at just one point in …
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Contributions to benzothiopyran chemistry
A series of 2,3-dihydro-4H-[1]benzothiopyran-4-ones has been prepared by the cyclocondensation of a thiophenol with cz,13-unsaturated carboxylic acids in methanesuiphonic acid and selectively oxidised to their 1-oxides and 1,1-dioxides. Reduction and dehydration of the resulting …
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Studies in Naphthopyran chemistry
A series of derivatives of naphtho[1,2-b]pyran and the [2,1-b] and [2,3-b] isomers has been prepared. Those compounds with aryl substituents adjacent to the hetematom have been obtained by an acid catalysed reaction of a naphthol with a 1,1- diarylprop-2yn-l-ol and thermal cyclisation of the …