Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 46 for “"Pyramidal cells"”.
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Calcium Regulation of a Slow AHP in Hippocampal Pyramidal Cells
… afterhyperpolarization (sAHP) in CA1 hippocampal pyramidal cells is calcium-dependent and involves activation of KCa3.1 and KCNQ potassium channels. Both KCa3.1 and KCNQ channels bind calmodulin (CaM) as a calcium sensor, with an additional role proposed for the protein hippocalcin. We measured …
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Temporal synchronization of CA1 pyramidal cells by high-frequency, depressing inhibition, in the presence of intracellular noise
… during periods of immobility. During the ripple, pyramidal cells synchronize over a short period of time despite the fact that these cells have sparse recurrent connections. Additionally, the timing of synchronized pyramidal cell spiking may be critical for encoding information that is passed on …
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Neural mechanisms involved in memory formation and retrieval within the rodent hippocampus : an in vivo electrophysiological study
… large-scale recordings from multiple single cells within the hippocampus of behaving rodents with pharmacological and genetic manipulations of hippocampal function in order to investigate how the cellular and network properties of the hippocampus contribute to memory storage and retrieval. In …
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AN ANATOMICAL AND IMMUNOCYTOCHEMICAL STUDY OF THE PRIMATE TEMPORAL AND FRONTAL CORTEX
… organisation. Golgi studies showed a variety of pyramidal and non-pyramidal neurons with specific varieties typical of individual cortical layers. The ultrastructure of the adult and infant cortex was further investigated in well-fixed biopsy specimens. Neuronal profiles were classified by …
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Large-scale neural recordings and biophysical models for inferring network mechanisms of ketamine anesthesia
… I built a computational network model of pyramidal cells and fast-spiking interneurons connected via synapses that include an experimentally verified scheme of NMDA receptor kinetics. I show that increased trapping, a known molecular feature of ketamine binding to the NMDA receptor, …
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Modulation of Prefrontal Cortex activity and sociability by local interneurons expressing corticotropi-releasing hormone
… primarily of two neuronal cell types: excitatory pyramidal cells and inhibitory interneurons. Their neurochemical diversity and complex organization into interconnected laminar and columnar circuits imbues the cortex with countless computational and functional possibilities. At the behavioral …
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Inhibition, Synapses, and Spike-Timing: Identification and disruption of pyramidal cell-interneuron interactions in SPW-Rs
… area CA1, interactions between excitatory pyramidal cells and inhibitory interneurons shape ensemble activity which encodes sequential experience. An extremely diverse set of inhibitory interneurons, with variation in gene expression, synaptic targeting, state-dependent activity, and …
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Retroviral envelope glycoproteins: mediators of neuropathology in nervous system development and neurodegeneration in HIV-1 infection
… epilepsy. In this study, we exposed cultured cells of the dentate gyrus (granule cells) and hippocampal gyrus (pyramidal cells) to gpl20 to assess their relative sensitivity to its neurotoxicity. Granule cells were resistant to concentrations of gpl20 which produce significant cell death …
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Role of serotonin2C receptor (5-HT2CR) in expression of cocaine-induced conditioned hyperactivity
… to the cell body and initial segment of axon of pyramidal cells, these results raise the possibility that the 5-HT2CR in the mPFC affects the parvalbumin-positive GABAergic interneurons to regulate the output of the pyramidal cells and therefore control expression of cocaine-induced conditioned …
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Biochemical and Genetic Studies of Beclin 1 Function in Autophagy
… targeted deletion of beclin 1 was performed in pyramidal cells of the hippocampus and the cerebral cortex and in cerebellar Purkinje cells. Consequently, the deletion leads to rapid and severe degeneration in these cells. In degenerating pyramidal cells, there is intracellular protein …
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Molecular mechanisms of neuronal homoeostasis in vivo
… the change in electrical properties of granule cells in the dentate gyrus and pyramidal cells in CA1 caused by expression of Kir2.1. I show that the excitability of neurones expressing Kir2.1 was reduced compared to control neurones. By 2 weeks after virus injection the neurones showed …
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Vasopressin decreases excitability in rat lateral amygdala neurons through inhibition of hyperpolarization-activated cationic current.
… current (Ih) amplitude in LA pyramidal cells. OT exerts complementary effects, causing an increase in action potential accommodation and Ih amplitude, resulting in decreased excitability. These results suggest AVP and OT may modulate social behavior by controlling excitability …
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Συναπτική δράση παραγώγων νευροδιαβιβαστών και αντιεπιληπτικών φαρμάκων στον εγκέφαλο φυσιολογικών και επιληπτικών πειραματοζώων
… in vitro recordings of field potentials from the pyramidal cells of hippocampal area CA₁ (2). Postsynaptic excitability as expressed by the PS/fEPSP input-output curves was found increased in tg/tg mice as compared to controls. Quantitative differences in the degree of synaptic activation of tg/tg …
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Effect of Background Synaptic Activity on Excitatory-Postsynaptic Potential-Spike Coupling
… with the dynamic clamp system. We recorded from pyramidal cells in neocortical slices<em> in vitro</em> to investigate how timing and probability of spike generation in response to an EPSP is affected by background synaptic conductance under these conditions. We found that near threshold, …
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CaMKII at a central synapse : α-calcium/calmodium protien kinase II and synaptic plasticity at CA3 Schaffer collateral -- CA1 synapses in the mammalian hippocampus
… [alpha]-CaMKII in adult hippocampal CA1 or CA3 pyramidal cells using conditional gene targeting. With this approach, we could investigate the locus of change that underlies LTP expression, as both pre- (CA3) and post- (CA1) synaptic CaMKII dependent mechanisms have been implicated, and further …
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Impaired and enhanced spatial representation of the PSD-95 knockout mouse
… absent in the mutants. This study explores CA1 pyramidal cell spatial representations in the PSD-95 mutant mice. Mutants are not significantly different than controls in running velocity. Nor are its pyramidal cells or interneurons different than controls in: place cell firing rates, sparsity of …
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Revised - THE ROLE OF GAD67/65 IN THE THERAPEUTIC EFFECTS OF KETAMINE AND FLUOXETINE IN FEAR-CONDITIONED MICE
… their direct inhibitory influence on excitatory pyramidal cells (PCs) throughout the amygdala, hippocampus, and PFC. This study quantified the expression GAD67/65 in brains harvested from mice that underwent FC and drug treatment from a previous published study conducted in our laboratory. …
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Eye-opening dependent elaboration and refinement of the cortical projection to the superficial superior colliculus in rats
… direct visual input from retinal ganglion cells (RGC) as well as input from pyramidal cells in layer V of the ipsilateral visual cortex (VC). The retinal input is refined well before eye opening (EO) and RGC axons arborize topographically to form an appropriate map of visual space. The …
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Optogenetic investigation of normal and pathological rhythms in the hippocampal formation
… mice, I found that gradual depolarization of CA1 pyramidal cells (mimicking CA3 sharp-wave input) is sufficient to induce fast gamma and sharp-wave ripple-like high frequency oscillations. I further demonstrate that the frequency of the oscillation is tightly correlated with the amplitude of the …
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