Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"Purkinje neurons"”.
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Age sensitivity of the Barnes Maze and the Morris Water Maze: Associations with cerebellar cortical Purkinje neurons
… change in anatomy across the life span (loss of Purkinje neurons), this study evaluated these behavioral tests in terms of sensitivity to both age-related changes in learning as well as age-related changes in the cerebellar cortex. A total of 65 CB6F1 mice were tested at one of five ages (4, 8, …
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Identification of Unique Hematopoietic Stem Cell Properties
… with hematopoietic cells and cardiomyocytes, Purkinje neurons, skeletal muscle and hepatocytes could be detected following injury induction of adult mice it did not occur in steady state tissues. On the other hand during fetal development lymphocyte-derived hepatocytes and Purkinje neurons …
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Characterization of the Paraneoplastic Cerebellar Degeneration Antigen Cdr2
… c-Myc colocalize exclusively to the cytoplasm of Purkinje neurons. We have found that the full length cdr2 and c-Myc proteins interact in vitro, and that this binding requires the basic helix-loophelix leucine zipper region of c-Myc. In addition, cdr2 represses c-Myc transcriptional activity in a …
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Spinocerebellar ataxia type 7 in southern africa: an epidemiological, molecular and cellular study
… suffer from selective degeneration of cerebellar Purkinje neurons and retinal photoreceptors, which leads to the development of various neurological symptoms, and blindness. SCA7 is considered to be a relatively rare disease, but South Africa has an increased prevalence of the SCA7 due to a …
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Neuronal Calcium Regulation and Cellular Stress in a Malignant Hyperthermia Disease Model
… this disease because RyR1 is highly expressed in Purkinje neurons. In this study, Y522S-RyR1 in Purkinje cells exhibits a lower threshold for activation, but does not cause severe cellular stress and damage. Future investigation of compensatory mechanisms for increased Ca2+ release in Purkinje …
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Neuronal Nitric Oxide synthase regulates the expression of EAAT4 and GAD65/67 in the murine cerebellum
… such as balance, coordination, and posture. Purkinje neurons (PNs) are the sole GABAergic output from the cerebellar cortex and receive major excitatory inputs via parallel fibers (PFs) that produce high levels of nitric oxide (NO) via neuronal nitric oxide synthase (nNOS). Previous studies …
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TTBK2 and Primary Cilia are Required for Purkinje Cell Survival
… found on almost every mammalian cell, including neurons and glia. Tau Tubulin Kinase 2 (TTBK2) is a critical regulator of the building of primary cilia, and mutations within Ttbk2 cause the adult-onset, neurodegenerative disease, Spinocerebellar Ataxia type 11 (SCA11). SCA11 is characterized by a …
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Developmental Dynamics of 5-Hydroxymethylcytosine and its Role in the Terminal Differentiation of Neurons
… in depth, little is known about how postmitotic neurons regulate their chromatin state. Modulation of transcription through the regulation of accessibility of transcription factor binding sites is essential for the regulation of migration, synapse formation and terminal differentiation. Although …
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A PROTEIN IN SEARCH OF FUNCTION: NIPSNAP1 IN MITOCHONDRIAL BRANCHED-CHAIN AMINO ACID METABOLON, BRAIN AND APOPTOSIS
… rat brain, NIPSNAP1 is expressed exclusively in neurons such as pyramidal neurons in cerebral cortex, Purkinje neurons in cerebellum and motor neurons in spinal cord. Dopaminergic and noradrenergic neurons, which are affected in PKU, also express NIPSNAP1. Brains of PKU mice show gender-specific …
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Characterization of Retinal Defects in Engrailed-2 Knockout (En2-/-) Mice, a Model for Autism Spectrum Disorders (ASD)
… hypoplasia (Joyner A L, et al., 1991), reduced Purkinje neurons numbers (Kuemerle B, et al., 1997), altered anatomy of the amygdala (Kuemerle B, et al., 2007), and a significant loss of forebrain GABAergic interneurons (SgadÃ2 P et al., 2013). En2-/- mice also display autistic-like behavioral …