Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 47 for “"Purkinje cells"”.
-
On the transmission properties of synapses made between granule cells and cerebellar Purkinje cells
… (LTP) can be observed at parallel fibre (PF) - Purkinje cell (PC) synapses. A presynaptic variant of cerebellar LTP can be evoked in PCs by raised frequency stimulation (RFS) of parallel fibre at 4-16Hz for 15s. This form of LTP is dependent on protein kinase A (PKA) and nitric oxide (NO), and …
-
Feedback control of cerebellar learning
… which consists of a set of interconnected nerve cells, cannot contain “internal models” or “have expectations”. The aim of this thesis is to untangle these metaphors by translating them back into neurophysiological cause and effect relationships. This task is approached from within the paradigm …
-
Regulation of Cerebellar Purkinje Cell Development: Interactions Between Trophic Factors and Neurotransmitters
… cell bodies, dendrites and axonal processes of Purkinje cells. The expression of the biologically active, high-affinity receptors was found to correlate with cerebellar development, and suggested that NGF may regulate the normal ontogeny of Purkinje cells. The development of cerebellar Purkinje …
-
Characterization and Treatment of A Novel Mouse Model of Tsc-Associated Autism
… gene was selectively deleted from cerebellar Purkinje cells (Tsc2f/-;Cre). These mice exhibit progressive Purkinje cell degeneration.</p> <p>Since loss of Purkinje cells is a well-reported postmortem finding in patients with ASD, we conducted a series of behavior tests to assess if Tsc2f/-;Cre …
-
Elucidating the reversibility of ataxia
… displaying motor deficiencies as well as reduced Purkinje cell firing frequency followed by dendritic tree degeneration and cell death. The aims of this study were to evaluate progression of Purkinje cell degeneration following loss of b-III spectrin function and determine whether the …
-
Neuronal Calcium Regulation and Cellular Stress in a Malignant Hyperthermia Disease Model
… this disease because RyR1 is highly expressed in Purkinje neurons. In this study, Y522S-RyR1 in Purkinje cells exhibits a lower threshold for activation, but does not cause severe cellular stress and damage. Future investigation of compensatory mechanisms for increased Ca2+ release in Purkinje …
-
A Map of Transcription Factor Expression in Neuronal Precursors of the Chicken and Mouse Embryonic Cerebellum
… cortex contains two principal neurons, the Purkinje cell (PC) and the granule cell (GC), whereas the CN are formed by an heterogeneous array of cerebellar nuclei neurons. Although granule cell development is well-studied, the specification and early migratory routes of cerebellar nuclei …
-
An Associative Memory Trace in the Cerebellar Cortex
… and James Albus (1971), it was proposed that Purkinje cells in the cerebellar cortex learn to associate the neutral conditioned stimulus with the response. Since their work, several studies have provided data that are consistent with this suggestion, but definitive evidence has been lacking. …
-
Developmental Dynamics of 5-Hydroxymethylcytosine and its Role in the Terminal Differentiation of Neurons
… epigenetic dynamics in mitotic differentiating cells have been characterized in depth, little is known about how postmitotic neurons regulate their chromatin state. Modulation of transcription through the regulation of accessibility of transcription factor binding sites is essential for the …
-
Roles Of Inhibitory Interneurons In Cerebellar Cortical Processing For Oculomotor Control
… stage of the cerebellar cortex. I recorded Golgi cells in the ventral paraflocculus: VPFL), a region of the cerebellum known to be involved in oculomotor behavior, while squirrel monkeys performed visual, vestibular, and eye movement tasks, and found that the VPFL Golgi cells only carry …
-
Surface recordings of evoked field potentials from the cerebellum with a flexmea microelectrode array
… mossy fiber pathway forms a disynaptic input to Purkinje cells through the granular cells. This disynaptic input produces a multicomponent field potential composed of the P1, N 1, N2, N3, N4, and P3 waves. The climbing fiber input forms a monosynaptic input to the Purkinje cells and thus creates …
-
Expression of Apolipoprotein E Receptor 2 (ApoER2) and Very Low Density Lipoprotein Receptor (VLDLR), Reelin Receptors in Development of Cerebellar Cortex
… the cortex, reelin is secreted by cajal-Retzius cells in the developing marginal zone and is required for inside-out layering of neurons in the cortical plate. Reelin binds to apolipoprotein E receptor 2 (ApoER2) and very low density lipoprotein receptor (VLDLR) that are members of lipoprotein …
-
A Purkinje cell Timing Mechanism. On the Physical Basis of a Temporal Duration Memory.
… that peaks near the end of the ISI. Cerebellar Purkinje cells that control the blink acquire adaptively timed pauses in spontaneous firing, conditioned Purkinje cell responses, that interrupt their tonic inhibition of cerebellar nuclear cells and cause excitatory output that generates the overt …
-
Molecular genetic characterization of ataxic movement disorders in mouse and human
… high level of ITPR1 expression in cerebellar Purkinje cells. In addition, high density genome wide SNP genotype data in humans showed a SUMF1-ITPR1 deletion to segregate with spinocerebellar ataxia 15 (SCA15), a late-onset autosomal dominant disorder, which was previously mapped to the genomic …
-
Characterizing Purkinje Cell Responses and Cerebellar Influence on Fluid Licking in the Mouse
… of licking in the simple spike activity of Purkinje cells and the consequences of loss of cerebellar function on licking behavior has not been quantified. I investigated the influence of the cerebellum on the maintenance of rhythm in murine fluid-licking.</p> <p>In one set of experiments, I …
-
Biochemical and Genetic Studies of Beclin 1 Function in Autophagy
… deletion of beclin 1 was performed in pyramidal cells of the hippocampus and the cerebral cortex and in cerebellar Purkinje cells. Consequently, the deletion leads to rapid and severe degeneration in these cells. In degenerating pyramidal cells, there is intracellular protein accumulation that …
-
Modulation of GABAergic transmission in the cerebellar stellate cell network by neurotransmitter spillover and synaptic cross talk
Cerebellar stellate cells are interconnected interneurons located in the outer molecular layer. They provide inhibition to Purkinje cells, thereby modulating the final output of the cerebellum. In this work, electrophysiological means were employed to study the stellate cell network at the single …
-
Defining The Functions of Usp22 and Usp44 In Regulation of H2Bub1 Levels
… associated with gene regulation in both normal cells and diseases. Many deubiquitinases (mainly USPs) are defined to regulate global H2Bub1 levels. However, how these USPs are regulated and how they contribute to diseases are not well understood.</p> <p>USP22, part of the deubiquitination module …
-
Role of The Gcn5 Histone Acetyltransferase In Spinocerebellar Ataxia Type 7 and In Immature Neurons
… in a mouse model of SCA7. Deletion of Gcn5 in Purkinje cells in mice expressing wild type Atxn7, however, causes only mild ataxia and does not lead to the early lethality observed in SCA7 mice. Reduced Gcn5 expression strongly enhances retinopathy in SCA7 mice, but does not affect the …
-
Deconvoluting Cell-Type Specific 3'UTR Isoform Expression in the Adult and Developing Cerebellum
… alternative polyadenylation between granule and Purkinje cells in the mouse cerebellum, as well as between proliferating and adult granule cells. Interestingly, among transcripts that differed in alternative polyadenylation in both these comparisons, many were involved in key neuronal functions. …
Page 1 of 3