Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 41 for “"Purkinje cell"”.
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TTBK2 and Primary Cilia are Required for Purkinje Cell Survival
… cilia can be found on almost every mammalian cell, including neurons and glia. Tau Tubulin Kinase 2 (TTBK2) is a critical regulator of the building of primary cilia, and mutations within Ttbk2 cause the adult-onset, neurodegenerative disease, Spinocerebellar Ataxia type 11 (SCA11). SCA11 is …
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Regulation of Cerebellar Purkinje Cell Development: Interactions Between Trophic Factors and Neurotransmitters
… to the localization of NGF binding sites to cell types in the developing cerebellum, and to the definition of receptor subtypes. <sup>125</sup>I-NGF binding was employed to delineate low- and high-affinity receptor sites in the postnatal rat cerebellum. Both high-affinity and low-affinity …
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Characterizing Purkinje Cell Responses and Cerebellar Influence on Fluid Licking in the Mouse
… of licking in the simple spike activity of Purkinje cells and the consequences of loss of cerebellar function on licking behavior has not been quantified. I investigated the influence of the cerebellum on the maintenance of rhythm in murine fluid-licking.</p> <p>In one set of experiments, I …
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A Purkinje cell Timing Mechanism. On the Physical Basis of a Temporal Duration Memory.
… is that a neuron can influence its target cell by exciting or inhibiting it. Learning is thought to involve strengthening or weakening synaptic connections. For most behaviors, the brain must learn to produce precisely timed activity patterns. Learned response timing is indispensable for a …
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The presence of naked purkinje cell dendritic spine specializations and other pathological changes in ten day saline and methylazoxymethanol-injected Swiss albino mice
Thesis (M.S.)--Michigan State University. Dept. of Anatomy, 1976
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An Associative Memory Trace in the Cerebellar Cortex
… and James Albus (1971), it was proposed that Purkinje cells in the cerebellar cortex learn to associate the neutral conditioned stimulus with the response. Since their work, several studies have provided data that are consistent with this suggestion, but definitive evidence has been lacking. …
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Elucidating the reversibility of ataxia
… displaying motor deficiencies as well as reduced Purkinje cell firing frequency followed by dendritic tree degeneration and cell death. The aims of this study were to evaluate progression of Purkinje cell degeneration following loss of b-III spectrin function and determine whether the …
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Characterization and Treatment of A Novel Mouse Model of Tsc-Associated Autism
… (mTORC1), which controls protein translation and cell growth. TSC causes substantial neuropathology, often leading to autism spectrum disorders (ASDs) in up to 60% of patients. The anatomic and neurophysiologic links between these two disorders are not well understood. However, both disorders …
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Cerebellar Coordination of Neuronal and Behavioral Rhythms
… dorsal CA1 (dCA1) using multisite in vivo extracellular recordings in freely moving mice. We compared a mouse model of cerebellar ataxia and their littermate controls. The ataxic mice were designed to have a genetically induced loss of Purkinje cell neurotransmission, resulting in an expected …
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Characterization of a Novel NPC1I1061T Knock-in Mouse Model of Niemann-Pick Type C1 Disease
… the free cholesterol accumulation leads to Purkinje cell loss in the cerebellum and is accompanied by neurodegenerative symptoms that include ataxia, vertical supranuclear gaze palsy, and decreased motor function. Most NPC1 patients succumb to the disease within the first two decades of …
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An anatomical analysis of the effects of ether anesthesia on the nerve cell
… to the anatomical changes produced in the Purkinje cell, a most highly differentiated type of nerve cell. It is this type of nerve cell upon which most of the previous work in this laboratory has been done as it is the most suitable of nerve cells for general study. However, the lower …
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Ataxin-1 in cognition and mood
… expansions of different lengths; and Purkinje cell specific Pcp2-ATXN1[82Q] mice to determine the cerebellar contribution. Atxn1-/- and Atxn1154Q/2Q mice showed cognitive deficits. Reduced hippocampal neurogenesis in Atxn1-/- mice may explain this. Cognition was not affected in …
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Computational studies of cerebellar cortical circuitry
… the error related signals are encoded by the Purkinje cell complex spike discharge. The results presented in this thesis show that the Purkinje cell simple spike activity robustly signals a rich representation of task specific performance errors, independently from the kinematic signals. The …
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Does cerebellar cortex function as a forward internal model for motor control?
… evaluate the simple spike firing from Purkinje cells in lobules IV-VI, we trained rhesus macaques to perform different hand movement tasks using a 2 joint robotic manipulandum. Two electrophysiology experiments tested several aspects of a forward internal model. First, we hypothesize …
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An investigation into the synaptic conditions and celluar mechanisms underlying cerebellar synaptic plasticity
… the connection between parallel fibres (PFs) and Purkinje cells can be modified by PF stimulation alone. Strong activation (Hartell, 1996) or high frequency stimulation (Schreurs and Alkon, 1993) of PFs induced a long-term depression (LTD) of PF-mediated excitatory postsynaptic currents. Brief …
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Localization of Goα in the Developing and Adult Mouse Brain
… both plasma- and endo-membranes, the precise subcellular location of Go protein has been a controversial issue because diverse detection methods such as in situ hybridization versus and immunohistochemistry yielded apparently contradictory results. We previously found that Go functions as a …
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Roles Of Inhibitory Interneurons In Cerebellar Cortical Processing For Oculomotor Control
… of a study of one such interneuron, the Golgi cell, which is the main type of inhibitory interneuron that regulates information flow at the input stage of the cerebellar cortex. I recorded Golgi cells in the ventral paraflocculus: VPFL), a region of the cerebellum known to be involved in …
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Understanding the Mechanisms of Motor Learning in the Vestibulo-ocular Reflex
… potentiation respectively, at the parallel fibre-Purkinje cell synapses. We demonstrate that learned gain increases, but not decreases, require the activation of type 1 metabotropic glutamate receptors (mGluR1) and B type γ-aminobutyric acid (GABAB) receptors. Blocking one or both of these …
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