Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 89 for “"Purkinje"”.
-
TTBK2 and Primary Cilia are Required for Purkinje Cell Survival
… 11 (SCA11). SCA11 is characterized by a loss of Purkinje neurons throughout the cerebellum causing ataxic phenotypes in affected individuals. </p><p>Given this connection, this body of work aims to define the role of primary cilia in maintaining neuron homeostasis through further defining roles …
-
Das axonale Regenerationspotential von Purkinje-Zellen in organotypischen Gewebekulturen des Kleinhirns
Die Purkinje-Zellen des Kleinhirns gehören zu den Nervenzellen im adulten ZNS, die eine Schädigung ihrer Nervenfasern in vivo normalerweise gut überleben, aber niemals eine spontane Regenerationsantwort oder gar eine Reinnervation ihrer Zielzellen zeigen. Um die Eigenschaften dieses Nervenzelltyps …
-
Contribution of the Purkinje System in Initiation and Maintenance of Arrhythmias
The Purkinje system is the conduction network of the heart that facilitates coordinated ventricular contraction and couples to the myocardium at discrete sites called Purkinje-Myocyte Junctions (PMJs). Fine and intricate geometry of the Purkinje system have confined experimental observations, …
-
Regulation of Cerebellar Purkinje Cell Development: Interactions Between Trophic Factors and Neurotransmitters
… cell bodies, dendrites and axonal processes of Purkinje cells. The expression of the biologically active, high-affinity receptors was found to correlate with cerebellar development, and suggested that NGF may regulate the normal ontogeny of Purkinje cells. The development of cerebellar Purkinje …
-
Characterizing Purkinje Cell Responses and Cerebellar Influence on Fluid Licking in the Mouse
… of licking in the simple spike activity of Purkinje cells and the consequences of loss of cerebellar function on licking behavior has not been quantified. I investigated the influence of the cerebellum on the maintenance of rhythm in murine fluid-licking.</p> <p>In one set of experiments, I …
-
A Purkinje cell Timing Mechanism. On the Physical Basis of a Temporal Duration Memory.
… that peaks near the end of the ISI. Cerebellar Purkinje cells that control the blink acquire adaptively timed pauses in spontaneous firing, conditioned Purkinje cell responses, that interrupt their tonic inhibition of cerebellar nuclear cells and cause excitatory output that generates the overt …
-
On the transmission properties of synapses made between granule cells and cerebellar Purkinje cells
… (LTP) can be observed at parallel fibre (PF) - Purkinje cell (PC) synapses. A presynaptic variant of cerebellar LTP can be evoked in PCs by raised frequency stimulation (RFS) of parallel fibre at 4-16Hz for 15s. This form of LTP is dependent on protein kinase A (PKA) and nitric oxide (NO), and …
-
Age sensitivity of the Barnes Maze and the Morris Water Maze: Associations with cerebellar cortical Purkinje neurons
… change in anatomy across the life span (loss of Purkinje neurons), this study evaluated these behavioral tests in terms of sensitivity to both age-related changes in learning as well as age-related changes in the cerebellar cortex. A total of 65 CB6F1 mice were tested at one of five ages (4, 8, …
-
An Associative Memory Trace in the Cerebellar Cortex
… and James Albus (1971), it was proposed that Purkinje cells in the cerebellar cortex learn to associate the neutral conditioned stimulus with the response. Since their work, several studies have provided data that are consistent with this suggestion, but definitive evidence has been lacking. …
-
Elucidating the reversibility of ataxia
… displaying motor deficiencies as well as reduced Purkinje cell firing frequency followed by dendritic tree degeneration and cell death. The aims of this study were to evaluate progression of Purkinje cell degeneration following loss of b-III spectrin function and determine whether the …
-
Feedback control of cerebellar learning
… neurophysiological evidence suggests that Purkinje cells, in the cerebellar cortex, generate the conditioned response. In addition, Purkinje cells provide negative feedback to the IO, which is a relay for the unconditional stimulus, via the nucleo-olivary pathway. Purkinje cells can …
-
The presence of naked purkinje cell dendritic spine specializations and other pathological changes in ten day saline and methylazoxymethanol-injected Swiss albino mice
Thesis (M.S.)--Michigan State University. Dept. of Anatomy, 1976
-
Characterization and Treatment of A Novel Mouse Model of Tsc-Associated Autism
… gene was selectively deleted from cerebellar Purkinje cells (Tsc2f/-;Cre). These mice exhibit progressive Purkinje cell degeneration.</p> <p>Since loss of Purkinje cells is a well-reported postmortem finding in patients with ASD, we conducted a series of behavior tests to assess if Tsc2f/-;Cre …
-
Neuronal Calcium Regulation and Cellular Stress in a Malignant Hyperthermia Disease Model
… this disease because RyR1 is highly expressed in Purkinje neurons. In this study, Y522S-RyR1 in Purkinje cells exhibits a lower threshold for activation, but does not cause severe cellular stress and damage. Future investigation of compensatory mechanisms for increased Ca2+ release in Purkinje …
-
A Map of Transcription Factor Expression in Neuronal Precursors of the Chicken and Mouse Embryonic Cerebellum
… cortex contains two principal neurons, the Purkinje cell (PC) and the granule cell (GC), whereas the CN are formed by an heterogeneous array of cerebellar nuclei neurons. Although granule cell development is well-studied, the specification and early migratory routes of cerebellar nuclei …
Page 1 of 5