Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"Purinergic receptors"”.
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Purinergic Receptors in the Circumvallate Papillae of Rats
<p>P2X2 receptors and P2Y4 receptors are ATP-activated cell surface receptors that gate movement of K+, Na+, and Ca2+. We used immunocytochemistry for P2X2 and P2Y4 receptors as well as taste cell type markers to learn if P2X2 immunoreactivity (IR) is present in nerve processes in close apposition …
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The role of purinergic receptors in the modulation of JNK signalling endothelial and cancer cells
Purinergic receptors (P2YR) are a family of G-protein coupled receptors (GPCRs) which have been shown to regulate MAPK (mitogen activated protein kinase) signalling to elicit pro-inflammatory responses in diseases such as atherosclerosis.1,2 Within the MAPK family, JNK (c-Jun NH2-terminal kinase) …
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Synthesis and biological evaluation of purine and pyrimidine based ligands for the A3 and P2Y2 purinergic receptors
P1-receptors, or adenosine receptors, and P2Y receptors, are G-protein-coupled receptors, belonging to the purinergic receptor family. Adenosine is the natural ligand of the P1 receptors, while P2Y receptors are activated by nucleotide ligands (ATP,ADP, UTP and UDP). The adenosine receptors (P1) …
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Extracullular Atp Regulates Il-1beta Release From Microglial Cells Via Purinergic Receptor After In Vitro Trauma
… and serves as a cell-to-cell mediator through purinergic receptors after in vitro injury. However, the mechanism of interleukin-1Beta release after traumatic brain injury remains poorly defined and is difficult to study using in vivo models. Using an in vitro model for traumatic brain injury …
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The role of the large conductance Ca2+-activated K+ channel in adenosine receptor-mediated cytoprotection
… properties to primary cardiomyocytes. Adenosine receptors are well known mediators of cardioprotection and trigger effectors such as the mitochondrial KATP channel – however, the role of the mitochondrial BKCa channel in adenosine receptor-mediated cardioprotection has not been investigated. GPCR …
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Analysis of Adenosine 2a Receptors During the Immune Recognition of Foreign and Self-Antigens
Purinergic receptors are attractive therapeutic targets that can regulate several facets of the immune system. This dissertation examines the role of purinergic G protein-coupled Adenosine 2a (A2aR) receptors in regulating adaptive immune responses during the primary response to vaccination and …
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Studies on Macrophage Migration in Pathological Contexts
… signalling molecule that signals through purinergic receptors. ATP, probably released from damaged neurons, can promote the migration of macrophages and microglia to the site of injury, and can be responsible for the onset of neuropathic pain. Purinergic signalling via ATP and other …
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An Investigation into the Function of CDS2 in Phosphoinositide Synthesis in Murine Macrophages
… of CDS2 deletion during stimulation of PLC by purinergic receptors was also investigated. Under conditions of chronic stimulation, CDS2-KO cells were unable to maintain their PI and PIP pools. This was also accompanied by an increase in PA accumulation and a substantial reduction in new PI …
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Direct neuronal and microglia-mediated effects of group I metabotropic glutamate receptors in neurodegenerative and neuroinflammatory processes
… glutamate (mGlu) receptor, mGlu1 and mGlu5 receptors are involved in neurodegenerative and in neuro-inflammatory processes. We have examined the role of mGlu5 receptor in a neuroinflammatory context. This receptor is expressed in glial cells and has been reported to play an anti-inflammatory …
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THE ROLE OF P2X7R IN METHAMPHETAMINE-INDUCED BEHAVIORAL CHANGES AND MICROGLIAL EFFECTOR FUNCTIONS
… therapies for METH addiction. Microglia express purinergic receptors, ligand-gated ion channels, which have been implicated in a variety of chronic inflammatory and neurodegenerative processes. In particular, P2X7R is activated by pathological concentrations of ATP. I show the concurrent …
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MOLECULAR PHYSIOLOGY OF THROMBOXANE A2 GENERATION IN PLATELETS
… activation. ADP activates platelets through two purinergic receptors namely P2Y1 and P2Y12 these receptors couple to Gq and Gi class of G-proteins, respectively. P2Y1 causes calcium mobilization through activation of PLC-β. P2Y12 inhibits adenylyl cyclase, causes activation of Rap1B and Akt. …
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Neural And Humoral Control Of Regional Vascular Beds Via A1 Adenosine Receptors Located In The Nucleus Of The Solitary Tract
… activation of NTS A<sub>1</sub> adenosine</p> <p>receptors yields variable hemodynamic responses with prevailing pressor and iliac</p> <p>vasoconstrictor responses. These responses are accompanied with differential</p> <p>activation of regional sympathetic activity (adrenal>>renal≥lumbar) and …
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Modulation of the vascular function by cannabinoids, calcitonin gene related peptide and connexin hemichannels
… can be mediated by stimulation of cannabinoid receptors. Others pointed a role for vanilloid receptors on perivascular nerves and a subsequent release of the neuropeptide CGRP. This peptide is one of the most potent vasodilatory substances and can act via an endothelium-dependent or …
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Pharmakologische Charakterisierung der purinergen Rezeptoren der Stützellen der olfaktorischen Mukosa des larvalen Xenopus laevis
Extrazelulläre Purine und Pyrimidine sind wichtige Signalmoleküle, die über membranständige Rezeptoren, so genannte purinerge Rezeptoren ihre biologischen Effekte vermitteln. In der vorliegenden Arbeit wurden ATP-induzierte Antworten in den Stützzellen des olfaktorischen Epithels mit Hilfe der …
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The Physiological Role of Serotonergic Transmission in Adult Rat Taste Buds
… discovery that this transmission is actually purinergic has left the actual role of serotonin in the taste bud enigmatic. Across mammalian species, 5-HT is highly conserved in type III cells of the bud, the only cells that form classic synaptic contacts with afferent nerve fibers. Previous …