Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 51 for “"Purinergic"”.
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Purinergic Signaling Regulates Filopodia-Induced Zippering
… no definitive cure for metastatic disease. The purinergic pathway’s generation of adenosine and its activation of the adenosine receptor A2B (A2BR) induces cell-cell adhesion to promote barrier function. This barrier function is known to be important in maintaining homeostasis during hypoxia, …
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Purinergic Signalling and Potassium Homeostasis Regulate Somatosensory Adaptation
Adaptation is the inhibition of firing in response to background stimulation which functions to allow neurons to respond to novel stimuli (Graczyk et al., 2018; Lampl & Katz, 2017; Mathis et al., 2017). This process takes place in the somatosensory cortex and is constantly happening, but the …
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Purinergic Receptors in the Circumvallate Papillae of Rats
<p>P2X2 receptors and P2Y4 receptors are ATP-activated cell surface receptors that gate movement of K+, Na+, and Ca2+. We used immunocytochemistry for P2X2 and P2Y4 receptors as well as taste cell type markers to learn if P2X2 immunoreactivity (IR) is present in nerve processes in close apposition …
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Elucidating Purinergic and Pro-inflammatory Signaling Mechanisms in Breast Cancer
… on the previous findings by elucidating a purinergic signaling mechanism propagated by breast cancer-secreted exosomes. Evidence presented here shows that the expression and phosphotransferase activity of a pro-angiogenic nucleoside disphosphate kinase (NDPK) are markedly elevated in …
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New purinergic-based pharmacological targets for the treatment of retinal disorders
… during diabetes induce the activation of the purinergic signaling pathway, which includes the P2X7 receptor (P2X7R). This ATP-gated ion channel has been linked to vascular inflammation due to an over-expression of cytokines, contributing to BRB alteration. The integrity of this physical …
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Purinergic angiogenesis : an investigation of the role of extracellular nucleotide mediated signaling in angiogenesis
… mucleotides that bind specific receptors termed Purinergic-type 2(P2) receptors. Since a number proliferation and migration in vitro, we propose that nucleotide signalling influences the process of angiogenesis in vivo.
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The role of purinergic receptors in the modulation of JNK signalling endothelial and cancer cells
Purinergic receptors (P2YR) are a family of G-protein coupled receptors (GPCRs) which have been shown to regulate MAPK (mitogen activated protein kinase) signalling to elicit pro-inflammatory responses in diseases such as atherosclerosis.1,2 Within the MAPK family, JNK (c-Jun NH2-terminal kinase) …
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Extracullular Atp Regulates Il-1beta Release From Microglial Cells Via Purinergic Receptor After In Vitro Trauma
… and serves as a cell-to-cell mediator through purinergic receptors after in vitro injury. However, the mechanism of interleukin-1Beta release after traumatic brain injury remains poorly defined and is difficult to study using in vivo models. Using an in vitro model for traumatic brain injury …
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Synthesis and biological evaluation of purine and pyrimidine based ligands for the A3 and P2Y2 purinergic receptors
… G-protein-coupled receptors, belonging to the purinergic receptor family. Adenosine is the natural ligand of the P1 receptors, while P2Y receptors are activated by nucleotide ligands (ATP,ADP, UTP and UDP). The adenosine receptors (P1) consist of 4 receptor subtypes: A1, A2A, A2B and A3. The …
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PURINERGIC TRANSMISSION IN MIGRAINE: ROLE OF P2Y RECEPTORS IN THE SPINAL-TRIGEMINAL SYSTEM IN VIVO AND IN VITRO
… the molecular and cellular role of the purinergic system in trigeminal pain transmission, in order to identify new potential targets for migraine pain therapy. In the first part of my PhD experimental work we have characterized the presence, functionality, and cellular localization of P2 …
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The role of nucleotides and the P2X7 receptor in radiation induced bystander effect
… effect have yet to be fully identified. Purinergic signalling is a nucleotide based signalling pathway that involves both the P2Yand the P2X receptors and activation of these receptors regulate many different functions. The prolific and varied functions of purinergic signalling receptors …
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Analysis of Adenosine 2a Receptors During the Immune Recognition of Foreign and Self-Antigens
Purinergic receptors are attractive therapeutic targets that can regulate several facets of the immune system. This dissertation examines the role of purinergic G protein-coupled Adenosine 2a (A2aR) receptors in regulating adaptive immune responses during the primary response to vaccination and …
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Localization of Human Prostaglandin E2 Receptors in Polarized Epithelial Cells
… compositions separated by tight junctions. Purinergic, muscarinic, and adrenergic receptors are a few examples of GPCRs that have been shown to localize to specific membranes in MDCK cells. The current work seeks to determine the differences in subcellular localization of the human …
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Studies on Macrophage Migration in Pathological Contexts
… signalling molecule that signals through purinergic receptors. ATP, probably released from damaged neurons, can promote the migration of macrophages and microglia to the site of injury, and can be responsible for the onset of neuropathic pain. Purinergic signalling via ATP and other …
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Differentiation Induces Dynamic Alterations in Mesenchymal Stem Cell Nuclear Architecture and Mechanotransduction
… histone-lysine N-methyltransferase EZH2. The ATP/purinergic signaling was a key regulator of this load induced chromatin condensation, and was mediated by acto-myosin cellular contractility. In follow on studies, we demonstrated that chromatin condensation in MSCs was regulated by interplay …
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Perinatal hypoxic-ischemic brain injury – characterization, mechanisms and treatment
… connexin hemichannels, pannexin channels and purinergic signaling, as well as to identify mechanisms of injury that are poorly attenuated by therapeutic hypothermia in order to find suitable additive treatments, such as Exendin-4. I showed that global cerebral ischemia was associated with a …
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Decoding Gating Properties of the Pannexin1 Channel: ATP Release and pH Sensitivity and the Potential Role in Health and Disease
… function. In sensory systems, ATP release and purinergic signaling is considered the most important function of Panx1. Here, the function in the olfactory epithelium was investigated using Panx1 knock out mice. Functional analysis in vivo confirmed a role in olfaction suggesting that Panx1 is …
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The role of the large conductance Ca2+-activated K+ channel in adenosine receptor-mediated cytoprotection
… receptors and Gq-coupled UTP-binding P2Y purinergic receptors on H9c2 cells. Activation of the adenosine A1 receptor with CPA (N(6)-cyclopentyladenosine) provided significant protection against hypoxia-induced cell death in these cells, as did opening of a BKCa channel with NS1619. The …
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The Sandwich Synapse: Trans-glial Signaling Between Neuronal Somata in the Dorsal Root Ganglion
… synapse involves ATP release from the neuron and purinergic activation of the glial cell. The second, glial cell to NS, synapse is glutamatergic. We find that inter-NS transmission at the DRG Sandwich Synapse involves Ca
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Direct neuronal and microglia-mediated effects of group I metabotropic glutamate receptors in neurodegenerative and neuroinflammatory processes
… formation occurs following activation of P2X7 purinergic receptors. We observed MVs development in pure microglial cultures, but, in the present study, they were more easily examined in the murine BV2 cell line. Activation of mGlu5 receptor attenuated the levels of pro-inflammatory cytokines, …
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