Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 36 for “"Pulsatile flow"”.
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Pulsatile Flow in Computational Modelling of Thrombosis in Cerebral Aneurysms
… utilizes computationally inexpensive steady flow conditions. However, pulsatile flow better characterizes blood flow in-vivo. Steady flow is an acceptable approximation of pulsatile flow from a fluid dynamics perspective, but there is no prior evidence suggesting whether it is an acceptable …
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LES of pulsatile flow in the models of arterial stenosis and aneurysm
… different types of Newtonian and non-Newtonian pulsatile blood flow in a constricted as well as in a dilated channel to gain insight of the transition-to-turbulent blood flow due to the arterial stenosis and aneurysm. In the stenosed model, a cosine shape stenosis is placed at the upper wall of …
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A Multi-Scale CFD Analysis of Patient-Specific Geometries to Tailor LVAD Cannula Implantation Under Pulsatile Flow Conditions: an investigation aimed at reducing stroke incidence in LVADs
… circulation in order to examine the effects on flow conditions resulting from varying the VAD cannula implantation location and angle of incidence of the anastomosis to the ascending aorta based on a patient-specific geometry obtained from CT scans. The multi-scale computation consists of a 0D …
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Computational model of thrombosis in cerebral aneurysms for predicting clotting outcomes in flow diverter treated patient-derived geometries validated with novel PIV-based ln vitro clotting flow experiment
… measuring the ongoing interaction between flow and clot-growth; a key factor in predicting aneurysm-occlusion after surgical placement of a stent. To this end, a pulsatile-flow direct thrombosis-model has been developed towards use in a clinical environment to predict thrombosis outcomes in …
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Pulsatile blood flow in the arteries
… partial differential equations for pulsatile flow in a flexible tube. The fluid is assumed to be a Newtonian, incompressible liquid similar to blood. The vessel is modeled as circular in cross section and tapering with increasing distance from the heart. The governing equations are …
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Application of passive flow control to mitigate the thromboembolic potential of bileaflet mechanical heart valves: an in-vitro study
… In this study, we explore the concept of passive flow controls that have been widely used in aerospace industry as a novel approach towards improving BMHV design. Passive flow control elements are small features on solid surfaces, such as vortex generators (VGs), that alter flow to achieve desired …
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The Use of Dynamic Fluid Flow Strategies for Bone Tissue Engineering Applications
… envisioned to guide bone healing in vivo. Fluid flow, which exerts a hydrodynamic shear stress on adherent cells, has been identified as one of the strongest stimuli on bone cell behavior. It has been shown to enhance the deposition of osteoblastic matrix proteins in vitro, and is particularly …
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A Computational Model of Aneurysmal Flow at the Abdominal Aorta
… model of the disease in order to couple inlet flow with outlet pressure. This model resulted in more precise hemodynamic conditions for pulsatile flow: 1- in terms of realistic wall pressure values and pressure curves, 2- realistic geometry effect. Contours of wall shear stress, mean wall shear …
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The Development of a Reduced Order Model for Prediction of Haemodynamic and Biochemical Changes in a Computational Cerebral Aneurysm Thrombosis Model
… Large timesteps overpredicted clot size in pulsatile flow. The rate of clot growth in pulsatile and plug flow were different; the predicted clot size in pulsatile flow was 14.6% greater than in plug flow. When variable diffusivity was used, the predicted clot size was 25.4% less than that …
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Modeling arterial blood flow using radial basis functions
<p>Investigation into the mechanics of blood flow in arteries helps provide insight into the mechanism of cardiovascular disease. As experimental measurements can be difficult, it is of interest to apply numerical simulation to the problem. This thesis examined fluid flow in arteries using a …
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Fluid-Structure Interaction of Large Viscoelastic Vessels Under Pulsatile Conditions
… into the response of compliant vessels to pulsatile flow for the purposes of properly characterizing the vessel-wall material properties. The structural deformation of, and flow field within, the compliant vessel were recorded using ultrasound imaging. The ultrasound data were then used to …
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The Role of Perivascular Fibrosis In Post-Stroke Glymphatic Impairment and Cerebral Amyloid Angiopathy
… amyloid-β (Aβ) proteins are transported by the pulsatile flow of cerebrospinal fluid (CSF) along perivascular drainage pathways. Ischemic stroke may disrupt this process, leading to a perivascular build-up of Aβ, termed cerebral amyloid angiopathy (CAA). I hypothesize that an abnormal pattern of …
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The Hydrodynamics of Ferrofluid Aggregates
… are governed by the interaction between the bulk flow shear stresses acting to wash away the aggregate and magnetic body forces acting to retain them at the magnet location. This interaction results in different aggregate dynamics, including the stretching and coagulation of the aggregate to …
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An examination of flow characteristics in collapsing elastic tubes
… mechanism was incorporated into a recirculating pulsatile flow system to simulate the physiologic problem cf coronary artery vasospasm. A dimensional analysis of the hemodynamic problem provided the basis for i) the specifications for elastic test sections (both straight and branching), ii) the …
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Investigation of the Hemodynamics of Coronary Arteries - Effect of Stenting
… fluid dynamics (CFD) simulations in a pulsatile flow with fluid-structure interaction (FSI) were carried out in realistic coronary arteries, with physiologically relevant flow parameters and dynamics due to induced motion of the heart. In addition, the geometric effects of the stent on …
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Design Of A Polysaccharide Derived Tissue Engineered Vascular Graft
… In-vitro, 3D scaffold cultures under non-pulsatile and pulsatile flow conditions were explored to generate vascular grafts with appropriate cellular alignment and tissue generation.</p> <p>We explored the prospect of a tissue engineered large vessel graft using polysaccharide biomaterials, …
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Oscillatory Flow Driven by Cavity
<p>Flows past a cavity are known to exhibit an oscillatory behavior with an amplitude and frequency dependent on the incoming flow properties and the geometry of the cavity. Experiments and numerical analyses have been performed to determine the effects of a flow passing through an axisymmetric …
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Smooth Flow Control for On-Chip Pneumatic Micropumps
… possible, it is necessary to generate the same flow profiles found in vitro. This thesis presents the development, implementation, testing, and iterative improvement of both hardware and software that composes a flow control system that produces smooth flow for on-chip pneumatic micropumps. By …
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A Mechano-Chemical Computational model of Deep Vein Thrombosis
… reactions between thrombin and fibrinogen, pulsatile blood flow, and clot growth within the vessel. The model was validated using a simplified experimental setup with flow, thrombin, and fibrinogen. Computational fluid dynamics (CFD) simulations were carried out using the ANSYS modelling …
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