Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"Pulmonary surfactant"”.
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Aspects Of Pulmonary Surfactant Metabolism
Pulmonary surfactant stabilizes the lung by reducing the surface tension at the air liquid interface of the alveolus. Phosphatidylcholine represents the principal component of surfactant (70% by weight), other lipids account for 20% of surfactant and the remaining 10% is protein. Four …
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Candidate genes other than the CFTR gene as possible modifiers of pulmonary disease severity in cystic fibrosis
… single gene Mendelian disorder characterized by pulmonary disease and pancreatic insufficiency. Pulmonary disease is the major cause of death in CF patients. Although some cystic fibrosis transmembrane conductance regulator (CFTR) genotypes are associated with less severe disease, patients …
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The effect of cis-platinum alone or in combination with radiation on mouse lung
… and some conflict as to whether it sensitises pulmonary tissue to the effects of radiation treatment. This project investigates the effect of cis-platinum alone or in combination with radiation on mouse lung. Four end points were used to evaluate treatments. They were: the release of pulmonary …
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Interfacial Reaction of an Olefin-Terminated Self-Assembled Monolayer Exposed to Nitrogen Dioxide: An Investigation Into the Reaction Rate and Mechanism
… inhalation of these pollutants have on the pulmonary surfactant of the lung, the only amicable air-water interface of the body. The fatty acids of this surfactant are as much as 30% unsaturated, and exposure to oxidizing pollutant is known to alter both the composition and function of the …
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Role of selenium in neonatal lung development
… functional and structural development, including pulmonary phospholipids and histomorphometry. Lung lesions due to hyperoxia were assessed by histopathological examination and by histomorphometry. Female Sprague Dawley rats were bred and fed a Se-deficient (0.03-0.04 ppm) diet or a Se-adequate …
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A study of the causes and consequences of SFTPC mistrafficking in alveolar type 2 cells using novel organoid models
Idiopathic pulmonary fibrosis (IPF) is a chronic lung disorder characterised by progressive lung parenchymal scarring, relentless lung function decline, and eventual respiratory failure. It is universally fatal with current treatments targeting downstream pathogenic pathways and only able to slow …
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Relationship between surfactant alterations and severity of disease in horses with recurrent airway obstruction (RAO)
Pulmonary surfactant is synthesized in the alveoli and lines the respiratory epithelium of the airways. Phospholipids, the main component of surfactant, confer it its ability to lower surface tension and to prevent alveolar collapse. Airway surfactant helps maintain smaller airway patency, improves …
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Respiratory complications of organophosphorus pesticide poisoning
… and designed and conducted a specific minipig pulmonary aspiration study which was complemented by an experimental OP poisoning ex vivo lung perfusion model and human data from pesticide poisoned patients in Sri Lanka. I first investigated the pulmonary pathophysiology resulting from orogastric …
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Lung Defects Contribute to Respiratory Symptoms in a Mecp2-mutant Mouse Model of Rett Syndrome
… these findings, Mecp2-mutant mice have altered pulmonary function. Finally, we treated whole body metabolism in Mecp2-mutant mice using lipid-modulating compounds, including statins and liver X receptor (LXR) agonists; both improved neurological and respiratory symptoms, suggesting clinical …
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The Potential Role of Cathelicidin Peptides for the Treatment of Lower Respiratory Tract Infections
… of invasive bacteria in the airways, leading to pulmonary inflammation and lung dysfunction. The development of antibiotic resistant bacterial infections has limited the effectiveness of current therapeutics and is particularly concerning in the setting of chronic bacterial infections, such as …
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Manipulating lipid mesostructure using hard and soft material additives
… (SAXS) is used to probe simple models of lung surfactant with up to 5 components. Supporting evidence of the hierarchical structure of lipid mixtures is collected using wide-angle x-ray scattering, solid-state NMR, and confocal fluorescence microscopy of multilamellar vesicles. I demonstrate …