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Showing 1 to 20 of 73 for “"Pulmonary fibrosis"”.
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The pathogenesis of idiopathic pulmonary fibrosis
Idiopathic pulmonary fibrosis (IPF) is a restrictive pulmonary disorder of unknown aetiology with a relentless disease course and a median survival of 3 years after the diagnosis. It is the most common idiopathic interstitial lung disease (ILD) with a basal and peripheral predominance associated …
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The role of sphingosine kinases in pulmonary fibrosis
Pulmonary Fibrosis is defined by the development of excessive connective tissue as a response to injury. One of the major mechanisms of fibroblast accumulation is epithelial-mesenchymal transition (EMT) and the Transforming Growth Factor-β1 (TGF-β1) is one of the growth factors that regulate this …
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Contribution of Interleukin 6 Trans Signaling In Pulmonary Fibrosis
<p>Idiopathic Pulmonary Fibrosis (IPF) is a lethal lung disease with progressive fibrosis and death within 2-3 years of diagnosis. IPF incidence and prevalence rates are increasing annually, and because the pathogenesis is unknown, there are no effective treatments available. Inhibition of …
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Approaches to lead generation for idiopathic pulmonary fibrosis targets
Idiopathic pulmonary fibrosis (IPF) is a common and devastating lung disease. There is currently no cure for IPF, and the limited pharmaceutical agents available to patients do not improve lung function, and only give moderate improvements in quality of life. Consequently, IPF is a major cause of …
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THE PREVALENCE AND PREDICTION OF PULMONARY FIBROSIS IN AN
… to determine the effects of asbestos exposure, pulmonary function and cigarette smoking in the prediction of pulmonary fibrosis. 613 workers who were occupationally exposed to asbestos for an average of 25.9 (SD=14.69) years were sampled from Sarnia, Ontario. A structured questionnaire was …
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The Role of Il-6 In Adenosine-Mediated Pulmonary Fibrosis
… mice leads to the development of pulmonary inflammation, alveolar destruction, and fibrosis, in conjunction with IL-6 elevation. Thus, it was hypothesized that IL-6 contributes to pulmonary inflammation and fibrosis in this model. To test this hypothesis, <em>Ada/IL-6</em> double …
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A study of platelets and the endothelium in idiopathic pulmonary fibrosis
Idiopathic pulmonary fibrosis (IPF) is a devastating lung disease associated with significant morbidity and early mortality. Despite this, the pathogenesis remains poorly understood and there is no effective disease modifying treatment. Epidemiological studies demonstrate an association between IPF …
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The Influence of SPARC on Collagen Deposition in Asbestos-Induced Pulmonary Fibrosis
<p>Pulmonary fibrosis involves the invasion of lung tissue with fibrotic, scar tissue and affects roughly five million people total worldwide. Fibrotic development in the lung has several causes, including chronic inflammatory diseases, infections, medical compounds, and environmental agents. There …
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The Influence of SPARC on Collagen Deposition in Asbestos-Induced Pulmonary Fibrosis
<p>Pulmonary fibrosis involves the invasion of lung tissue with fibrotic, scar tissue and affects roughly five million people total worldwide. Fibrotic development in the lung has several causes, including chronic inflammatory diseases, infections, medical compounds, and environmental agents. There …
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The Role of Mesenchymal Stromal Cells in Inflammation and Treatment of Pulmonary Fibrosis
… and their potential benefits in treating pulmonary fibrosis. This was achieved through a series of in vitro studies and an in vivo model of lung disease, namely, bleomycin induced pulmonary fibrosis. Firstly MSC expansion of Treg cells was shown to be dependent on Jagged 1 signalling. MSC …
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MMP-7 nanosensors for urine-based detection of chemotherapy-induced senescence and pulmonary fibrosis
… In addition, it could be used to detect lung fibrosis, a condition associated with elevated levels of MMP-7, in a mouse model. In summary, this work introduces a simple, versatile, and non-invasive sensing platform for colourimetric and spectroscopic detection of therapy-induced senescence …
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Sine Oculis Homeobox Homolog 1 (Six1) Plays A Critical Role In The Progression of Pulmonary Fibrosis.
<p>Idiopathic pulmonary fibrosis (IPF) is the most common idiopathic interstitial pneumonia with a median survival time of 2-4 years after diagnosis. The alarming mortality rate is due to the lack of effective treatments. IPF is a chronic disease that is characterized by alveolar destruction due to …
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CHARACTERIZATION AND EVALUATION OF CLINICALLY RELEVANT READOUTS IN A PRE-CLINICAL MODEL OF IDIOPATHIC PULMONARY FIBROSIS (IPF)
Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive age-related interstitial lung disease (ILD) with a poor prognosis and very limited therapeutic options (Raghu et al. 2015; Spagnolo et al. 2018). To date, Pirfenidone and Nintedanib are the only two therapies approved for IPF worldwide. …
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The Association of demographic and physiological variables and risk of subsequent disease progression in idiopathic pulmonary fibrosis
… Efficient clinical trial design in idiopathic pulmonary fibrosis (IPF) is hindered by incomplete understanding of the natural history of IPF and absence of robust predictive models. A retrospective analysis of the RAINIER clinical trial for simtuzumab, an inhibitor of lysl-oxidase-like-2 …
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Lung Progenitor Cell Transplantation for Pulmonary Fibrosis and Ex Vivo Expansion of Patch-Forming EpCAM⁺CD31⁺ Cells
<p>Idiopathic pulmonary fibrosis (IPF) and other chronic interstitial lung diseases are characterized by progressive destruction of the alveolar architecture, leading to irreversible respiratory failure. Although recent pharmacologic interventions can slow disease progression, lung transplantation …
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The Hypoxic Adenosine Response Modulates Macrophage Differentiation and Contributes to Lung Disease
<p>Idiopathic pulmonary fibrosis (IPF) is a chronic lung disease which affects 5 - 8 million individuals worldwide and 200,000 individuals in the United States alone. Although prevalent, we do not know what causes IPF and no effective curative treatment exists for this disease. Our laboratory has …
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Role of type I interferon in pulmonary inflammation and fibrosis
Pulmonary fibrosis is a severe and potentially fatal lung disorder characterized by progressive respiratory dysfunction, imposing significant burdens on both society and affected families. This condition frequently occurs secondary to other diseases, particularly autoimmune disorders, where the …
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