Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 17 of 17 for “"Pulmonary drug delivery"”.
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Proniosome formulations for pulmonary drug delivery
… dipropionate (BDP, 5 mole %) as a model drug. When niosomes were processed via probe sonication, photon correlation spectroscopy study showed that niosomes generated from proniosomes had larger size than conventional niosomes, being 202 nm and 160 nm, respectively. Transmission electron …
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Investigating Controlled Release Pulmonary Drug Delivery Systems
The therapeutic effect of pulmonary drug delivery systems is limited by its rapid clearance from the lungs by robust clearance mechanisms. By controlling the release of drugs, the therapeutic effect of pulmonary drug delivery systems, as well as patient convenience and compliance could be improved …
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Proliposome and Prosurfactosome Formulations for Pulmonary Drug Delivery
… vesicles (surfactosomes) using the hydrophilic drug salbutamol sulphate (SBS) and the hydrophobic drug beclometasone dipropionate (BDP) for pulmonary delivery via nebulisation. Initially liposomes and surfactosomes with or without cholesterol were prepared using thin film method and were …
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Modified Release of Agglomerated Nano-Particles for Pulmonary Drug Delivery
The delivery of nanoparticulate medicines to the lungs via the pulmonary route presents many challenges. Nanoparticles tend to lack sufficient mass and are principally exhaled and not deposited in the lungs. However, they also tend to form aggregates or agglomerates to reduce the free energy of the …
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Nanotechnology in pulmonary drug delivery: Compressible proliposome formulations for nebulization
… are promising carriers for the encapsulation of drug molecules and subsequent delivery to the respiratory tract. The advantages of liposomes as carriers have been widely reported in literature, there are however associated disadvantages such as stability issues when suspended in aqueous media. …
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Nanoparticle based chemotherapy for pulmonary drug delivery in treating lung cancer
… as non-ionic surfactant vesicles (NIVs), as a drug delivery system for the treatment of lung cancer by inhalation. NIV formulation was developed and characterized and the efficacy of the NIVs encapsulated chemotherapeutic drugs as single agents and in combination were then compared with the …
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Particle Engineering via Spray Freeze-Drying for Pulmonary Drug Delivery Applications
L'abstract è presente nell'allegato / the abstract is in the attachment
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Biophysical Characterization of Nanoparticle Interactions with Lung Surfactant Models for Enhanced Pulmonary Drug Delivery
Inhalable nanoparticles for drug delivery has shown promising results in the treatment of lung disease. The impact of these small sized drug carriers on the lungs is remains unclear. One of the first barriers that nanoparticles will encounter upon inhalation is the lung surfactant that lines each …
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Design Of Functional Dendrimer Nanocarriers And Their Formulations In Propellant-Based Inhalers For Pulmonary Drug Delivery
… developing pressurized metered dose inhalers for pulmonary drug / gene delivery to and through the lungs. First challenge is to design biocompatible moieties for the steric stabilization of suspension formulations in HFO-based propellants. Using a combination of tools including ab initio …
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PULMONARY DELIVERY OF RESVERATROL-LOADED NANOCOMPOSITE MICROPARTICLES TO TREAT LUNG CANCER
… involves the administration of cytotoxic drugs that kill all cells exhibiting a high rate of proliferation and regeneration, which is a characteristic of cancer cells, but also non-cancerous cells, such as hair follicles, bone marrow and gastrointestinal tract cells. Therefore, the …
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Novel Technology for Crystal Engineering of Pharmaceutical Solids
… component to produce micro sized particles for pulmonary drug delivery system via dry powder inhaler (Foradil inhaler). The results demonstrate that the THF particles generated using MASCW process displayed greater aerodynamic performance compared to conventional spray-dried THF sample. In the …
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Creation and validation of an enhanced in vitro model of the lungs
The increasing prominence of pulmonary drug delivery for local and systemic treatments coupled with the complex lung structure and the numerous factors affecting the pulmonary delivery of drugs has necessitated extensive research on this drug delivery route. The research mostly includes studies on …
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Control of crystalline particle properties by spray drying
… aims to deliver consistent and sustainable drug products of a better and higher quality. Spray drying is a continuous processing technique typically adopted for amorphous solid production. However, the unique conditions of the technique can also can be adapted and applied to crystallisation …
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Efficacy of a Magnetic Drug Delivery System and Development of an Orthotopic Lung Tumor Imaging Model
… aim of this work was the development of a novel drug delivery vehicle termed nano-in-microparticles (NIMs) to evaluate the magnetic-field dependent targeting of dry powder NIMs administered endotracheally using an ex vivo and in vivo rodent model. NIMs are a novel dry powder drug delivery vehicle …
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SPRAY-DRIED BIOADHESIVE FORMULATIONS FOR PULMONARY DELIVERY
… microparticles prepared using spray-drying for drug delivery to the lung via dry powder inhalers. Bioadhesive formulations such as prochitosome or chitosome powders have been introduced to overcome the drawbacks of liposome instability and potentially provide significant increase in the …
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Polymeric nanocarriers for the regional and systemic delivery of therapeutics to and through the lungs
… (PNCs) have several advantages over other drug delivery vehicles including sustained release of moieties, ease of cellular internalization and improved targeting, and hence hold the promise to greatly augment the potential of OI therapies. The surface chemistry, architecture, and size of …