Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 26 for “"Pulmonary delivery"”.
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Pure Insulin Nanoparticle Agglomerates for Pulmonary Delivery
Diabetes is a disease characterized by defects in insulin utilization, either through autoimmune destruction of insulin-producing cells (Type I) or insulin resistance (Type II). Treatment includes regular insulin injections, which can be painful and inconvenient, often leading to low patient …
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SPRAY-DRIED BIOADHESIVE FORMULATIONS FOR PULMONARY DELIVERY
… prepared using spray-drying for drug delivery to the lung via dry powder inhalers. Bioadhesive formulations such as prochitosome or chitosome powders have been introduced to overcome the drawbacks of liposome instability and potentially provide significant increase in the residence …
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An Electrospray Solution to the Pulmonary Delivery Problem
… diagnosis of lung disease and enable local delivery of therapeutics to the lungs. Delivering molecules into the lung and airway tissues is challenging. The methodology is to design and implement an electrospray device for delivery of molecules to the respiratory tissues and to analyse its …
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PULMONARY DELIVERY OF RESVERATROL-LOADED NANOCOMPOSITE MICROPARTICLES TO TREAT LUNG CANCER
… tract cells. Therefore, the systemic delivery of chemotherapy leads to adverse effects, such as chemotherapy induced alopecia (CIA) and chemotherapy-induced peripheral neuropathy (CIPN), which can range from life-altering to life-threatening. Moreover, the economic impact of current …
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PULMONARY DELIVERY OF PNEUMOCCOCAL VACCINE USING NANOCOMPOSITE MICROPARTICLE CARRIERS VIA DRY POWDER INHALATION
… for developing polymeric based NCMPs for vaccine delivery via inhalation against pneumococcal diseases.
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Preparation and Evaluation of Oil-in-Water Self-Nanoemulsifying Systems with Potential for Pulmonary Delivery
Self-Nanoemulsifying Drug Delivery Systems (SNEDDS) are mixtures of oil, surfactant and cosolvent/cosurfactant, which emulsify under conditions of gentle agitation. SNEDDS can drastically improve absorption of poorly water soluble drugs by keeping it in solubilized form at the site of absorption. …
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Purification and quantitative description of Rhodococcus equi IgG designed for aerosol nebulization to foals
… Rhodococcus equi plasma and to assess the delivery of IgG as an aerosol to the equine lung. IgG was purified from plasma, and the IgG concentration of both the plasma and the purified IgG was determined by ELISA. The purified IgG was aerosolized using a vibrating mesh nebulizer and aerosol …
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Innovatives liposomes for overcoming biological barriers
… and chitosomes loading curcumin are designed for pulmonary delivery as a cure for cystic fibrosis. In this case, has been tested the toxicity of the system using a model of lung tissue using Calu-3 cells. The drug delivery via liposomes and chitosomes improves the retention time of the drug and …
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Immunization with synthetic nanoparticles to generate mucosal CD8 T Cell responses
… the successful use of liposomes for drug delivery, has made liposomes an attractive candidate for vaccine delivery. Here, we investigate the efficacy of using a novel nanoparticle system, Interbilayer Crosslinked Multilamellar Vesicles (ICMVs), as a mucosal vaccine to stimulate mucosal and …
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Development of non-ionic surfactant vesicles for inhaled drug delivery
… and little is know about their use for inhaled delivery. Therefore, in this study, NIVs for pulmonary delivery were developed and factors, which affected their efficacy and stability, were determined. The addition of the cryoprotectant sucrose to NIVs containing amphotericin B (AmB-NIVs) allowed …
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Formulation studies on cysteamine for the treatment of nephropathic cystinosis.
… ophthalmic gels and bovine corneal tissue. The pulmonary microspheres were spherical and within the optimum size range for deep lung delivery (1-5 micro-m). However, Andersen Cascade Impactor analysis revealed poor deep-lung penetration. In conclusion, these results demonstrated that more …
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Development of an inhalable nanomedicine for lung cancer
… inhalable powder using a spray drying method for pulmonary delivery. However, the main challenge is maintaining the stability and functionality of NPs. Herein, RALA peptide that had been successfully incorporated into different formulations, e.g. wound patch and hydrogel, was used to condense …
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NOVEL CINNAMIC ACID-BASED DEHYDROPOLYMERS FOR EMPHYSEMA: IN VITRO AND IN VIVO ASSESSMENT OF THEIR ACTIVITIES
<p>Pulmonary emphysema is a serious worldwide illness, causing progressive and irreversible alveolar wall loss and difficulty in breathing. It is caused mostly by cigarette smoking. However, its unresolved complex and multiple pathogenic mechanisms have left this disease without effective …
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The design and analysis of sugar-based carrier systems for the protection of nucleic acids
… to develop biopharmaceutical particles for the pulmonary delivery. However, it runs the risk of loss of biological activity, sample instability as well as thermal degradation of the biopharmaceutical. Results showed that plasmid DNA degradation was reduced when co-spray dried in the presence of …
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Aerosolizable Drug-Loaded SPIONs for Treatment and Diagnosis of Pulmonary Tuberculosis
… these limitations, this study aimed to develop a pulmonary theranostic platform composed of poly(lactic-co-glycolic acid)-polyethylene glycol (PLGA-PEG) coated superparamagnetic iron oxide nanoparticles (SPIONs), capable of delivering antitubercular agents directly to the site of infection while …
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Performance of two different types of inhalers. Influence of flow and spacer on emitted dose and aerodynamic characterisation.
… well as the methods of studying deposition and pulmonary delivery devices. This section includes the basis of asthma and COPD and its treatment. In addition, a short section is presented on the role of the pharmacist in improving asthma and COPD patient¿s care. Therefore the thesis is divided …
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Investigating Controlled Release Pulmonary Drug Delivery Systems
The therapeutic effect of pulmonary drug delivery systems is limited by its rapid clearance from the lungs by robust clearance mechanisms. By controlling the release of drugs, the therapeutic effect of pulmonary drug delivery systems, as well as patient convenience and compliance could be improved …
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MicroRNA Nanocarriers for the Treatment of Chronic Obstructive Pulmonary Disease
Chronic obstruction pulmonary disease (COPD) is a major cause of morbidity and mortality across the world. COPD is currently the fourth leading cause of death in the world and is predicted to become the third leading cause of chronic illness and death worldwide by 2030. There are several …
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Creation and validation of an enhanced in vitro model of the lungs
The increasing prominence of pulmonary drug delivery for local and systemic treatments coupled with the complex lung structure and the numerous factors affecting the pulmonary delivery of drugs has necessitated extensive research on this drug delivery route. The research mostly includes studies on …
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Proliposome and Prosurfactosome Formulations for Pulmonary Drug Delivery
… drug beclometasone dipropionate (BDP) for pulmonary delivery via nebulisation. Initially liposomes and surfactosomes with or without cholesterol were prepared using thin film method and were compared for their VMD, span and drug entrapment. Their drug retention on extrusion through 5µm, …
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