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Showing 1 to 20 of 20 for “"Pulmonary circulation"”.
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Remodeling of the pulmonary circulation - a novel response to allergic airway inflammation
… focused on the tracheal and bronchial microcirculation, as these vessels are relatively easy to obtain. Some scattered studies have investigated bronchial and pulmonary arteries, using autopsy specimens. The overall aim of the project was to investigate vascular remodeling by utilizing two …
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Origins of Systemic to Pulmonary Collateral Arteries and their Relative Frequencies in Patients with Pulmonary Artery Atresia or Stenosis as determined using Multidetector Computed Tomography Angiography
INTRODUCTION: Critical to the management of pulmonary atresia (PA) or pulmonary stenosis (PS) is accurate and comprehensive knowledge of the vascular network supplying the lungs. This vascular network can be exceedingly complex as it may include a wide variation of systemic to pulmonary collateral …
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Molecular events governing hematopoietic stem cell recruitment in Vivo in murine liver following Ischemia-reperfusion injury
… HSC recruitment to injured hepatic microcirculation are poorly understood. These mechanisms were investigated in vivo following murine hepatic ischemia-reperfusion (IR) injury. HSC adhesion was significantly enhanced in injured livers and could be reduced by blocking CD49d on HSCs or …
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ΛΕΙΤΟΥΡΓΙΚΟΤΗΤΑ ΤΟΥ ΑΓΓΕΙΑΚΟΥ ΠΝΕΥΜΟΝΙΚΟΥ ΕΝΔΟΘΗΛΙΟΥ, IN VIVO, ΥΠΟ ΦΥΣΙΟΛΟΓΙΚΕΣ ΚΑΙ ΠΑΘΟΛΟΓΙΚΕΣ ΣΥΝΘΗΚΕΣ
BESIDES GAS EXCHANGE, THE PULMONARY CIRCULATION HAS ANOTHER IMPORTANT FUNCTION,A METABOLIC ONE. PULMONARY VASCULAR ENDOTHELIUM PARTICIPATES IN VARIOUS IMPORTANT PHYSIOLOGIC AND PHARMACOKINETIC PROCESSES WHICH ARE SUSCEPTIBLE TO DIFFERENT PHARMACOLOGICAL, PHYSICAL AND TOXIC AGENTS. UNDER …
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Liposomal delivery of PDE5 inhibitors and UT-15C to human erythrocytes
… However, erythrocytes from patients with pulmonary arterial hypertension (PAH) fail to release ATP in response to the physiological stimuli of exposure to low oxygen tension or mechanical deformation of a magnitude these cells would encounter in the pulmonary circulation. This defect could …
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Cellular mechanisms of acute hypoxic pulmonary vasoconstriction in intrapulmonary veins.
In the pulmonary circulation, alveolar hypoxia contributes to blood flow regulation. Hypoxic pulmonary vasoconstriction (HPV) involves both pulmonary arteries and veins, but little is known of the contractile mechanisms specific to the veins. The aim of these studies was to examine the hypoxic …
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Incidence and Pathogenesis of Acute Lung Injury and the Acute Respiratory Distress Syndrome in Humans
… are conditions characterised by neutrophilic pulmonary inflammation, refractory hypoxaemia and diffuse alveolar damage. This work reports on the first UK based prospective study of the incidence and longer term mortality of ALI/ARDS in a general intensive care unit. Results reveal significant …
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Prenatal Cardiovascular Physiology and Early Neurodevelopment in Cyanotic Congenital Heart Disease
… to measure oxygen transport across the fetal circulation. Among fetuses with cyanotic CHD, diminished fetal combined ventricular output was associated with mortality, whereas cerebral blood flow and oxygen delivery were associated with early cognitive, language, and motor development at …
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Hypoxia-mediated human pulmonary arterial fibroblast proliferation is dependent on p38 mitogen-activated protein kinase activity.
Abstract Background: Pulmonary hypertension (PH) is a rare condition that can occur as a primary disease process, Idiopathic Pulmonary Hypertension (IPH) or secondary to other disorders. In Familial IPH mutations have been identified in the bone morphogenetic protein receptor II gene (BMPRII) …
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Effects of vagal stimulation on the pulmonary microcirculation of rabbit, dog, and cat
Thesis (M.S.)--Michigan State University. Dept. of Anatomy, 1970
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Expression of leukocyte-endothelial adhesion molecules during acute inflammation in the lung
… response of PMNsto inflammation. In the systemic circulation, the leukocyte adhesion molecule, L-selectin, facilitates PMN adhesion to inflamed endothelium while CD11/CD18 is required for PMN emigration into extravascular tissues. An inducible endothelial ligand for CD18 is intercellular adhesion …
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A holistic multi-scale mathematical model of the murine extracellular fluid systems and study of the brain interactive dynamics
… heart dynamics, major arteries and veins, microcirculation, pulmonary circulation, venous valves, cerebrospinal fluid (CSF), brain interstitial fluid (ISF), Starling resistors, Monro-Kellie hypothesis, brain lymphatic drainage and the modern concept of CSF/ISF drainage and absorption based on …
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Local Control of Blood Flow in the Bronchial Circulation of Dogs
The bronchial circulation supplies nutritive flow to the conducting airways.I studied the local control of blood flow in the bronchial circulation of dogs. The three aims of my study of the bronchial circulation were to determine: 1) distribution of blood flow from the right bronchial artery: 2) …
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Design of Percutaneous Dual Propeller Pump to assist Patients with Single Functional Ventricle
… ventricle, which perfuses both the systemic and pulmonary circulation in parallel. A three-stage palliation procedure, including the final Fontan Completion, is often adopted by surgeons to treat patients with such CHDs. However, the most common outcome of this surgery, an extra-cardiac total …
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Hemodynamic Optimization of a Passive Assist Total Cavopulmonary Connector for ages 1-20
… vena cava directly to the left and right pulmonary arteries bypassing the right atrium. However, this is not the most efficient configuration from a hemodynamics perspective. The goal of this study is to develop a patient-specific 4-way connector to bypass the dysfunctional right ventricle …
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Modelling cardiopulmonary interactions. Towards anatomically detailed and physiologically accurate cardiorespiratory models
… system and the heart, but also for systemic and pulmonary circulatory districts. This work introduces a novel geometrically multiscale 1D-0D model that couples the fine description of blood flow in 1D domains obtained through the closed-loop Anatomically-Detailed Arterial-Venous Network (ADAVN) …
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The role of pulmonary arterial stiffness in right ventricular remodelling in COPD
COPD is the second most common cause of pulmonary hypertension, and is a common complication of severe COPD with significant implications for both quality of life and mortality. Pulmonary arterial stiffening occurs early in the disease process before the development of overt pulmonary hypertension. …
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Computational modelling of global haemodynamics and its interaction with cerebrospinal fluid and brain dynamics with application to essential hypertension
… firstly, the potential link between the venous circulation and several neurological pathologies, secondly arterial hypertension. The work presented in this thesis consists of a multiscale model of the global, arterio-venous circulation in the entire human body. The present model represents an …
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Relationship of Ventilation Ability and Positioning in Left-Sided Congestive Heart Failure Patients
<p>Proper positioning is used to relieve dyspnea, edema, and fatigue in congestive heart failure patients. According to the review of literature, improved ventilation as measured by specific lung volumes and lung mechanics occurred with upright positioning in normal persons. The effects of specific …