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Showing 1 to 20 of 20 for “"Pulmonary arteries"”.
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The Role of Mitochondria in Oxygen Sensing of the Ductus Arteriosus and Fetal Pulmonary Arteries
… responses of the ductus arteriosus (DA), adult pulmonary arteries (PA) and other oxygen sensing tissues. However, the fetal PA oxygen response has been little studied, the identity of the DA oxygen sensor remains elusive, and the basis for the opposing oxygen responses of the DA …
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Closed-Loop CFD Analysis of the Fontan Cardiovascular Circulation
… back to the heart, are linked directly to the pulmonary arteries, bypassing the atrial connection. Even though this operation has been around for years, the patients who have undergone this operation have experienced chronic illnesses and their surviving probability is about 50% by age twenty. …
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Multi-Scale Fluid Flow Analysis of the Cardiovascular System
… body back to the heart, are connected to the pulmonary arteries. Despite the fact that the Fontan operation has been executed for years, it is still not the effective palliation to heal HLHS patients since those who have undergone this procedure experience chronic diseases. In order to …
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Hemodynamic Optimization of a Passive Assist Total Cavopulmonary Connector for ages 1-20
… vena cava directly to the left and right pulmonary arteries bypassing the right atrium. However, this is not the most efficient configuration from a hemodynamics perspective. The goal of this study is to develop a patient-specific 4-way connector to bypass the dysfunctional right ventricle …
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Lumped Parameter Model for a Self Powered Fontan Palliation of the Hypoplastic Left Heart Syndrome
… venous returns are connected directly to the pulmonary arteries to allow the single functioning ventricle to perfuse the systemic circulation, has been around for decades, yet the patients who undergo this operation suffer from chronic illnesses and their survivability is less than 50% by …
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Non-invasive early diagnosis of deep vein thrombosis
… deep vein and can travel to lung and block pulmonary arteries. This condition will cause fatal Pulmonary Embolism (PE). DVT can be diagnosed using non-invasive technique such as ultrasonography. One of the factors that cause the deep vein thrombosis occurs is the behaviour of vein valve. …
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Remodeling of the pulmonary circulation - a novel response to allergic airway inflammation
… studies have investigated bronchial and pulmonary arteries, using autopsy specimens. The overall aim of the project was to investigate vascular remodeling by utilizing two different animal models of allergic airway inflammation (where chicken egg albumin (OVA) or house dust mite (HDM) …
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Cellular mechanisms of acute hypoxic pulmonary vasoconstriction in intrapulmonary veins.
In the pulmonary circulation, alveolar hypoxia contributes to blood flow regulation. Hypoxic pulmonary vasoconstriction (HPV) involves both pulmonary arteries and veins, but little is known of the contractile mechanisms specific to the veins. The aim of these studies was to examine the hypoxic …
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Pulmonary arterial pulse wave velocity measurement in horses
Calcification of the tunica media of the main pulmonary arteries (PA) has been reported in a large proportion of racehorses. In humans, medial calcification is a significant cause of arterial stiffening and is implicated in the pathogenesis of cardiac, cerebral and renal microvascular diseases, as …
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Elucidating the roles of endothelial PTBP1 and PKM2 in Pulmonary Arterial Hypertension: implications for therapy
Pulmonary Arterial Hypertension (PAH) is a rare, life-limiting disease with no cure, and is regarded the most severe form of pulmonary hypertension (PH). The disease is characterised by remodelling of peripheral pulmonary arteries, leading to increased mean pulmonary arterial pressure, right …
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Predicting pulmonary hypertension and outcomes in patients with left heart disease
Pulmonary hypertension (PH) is defined as a rise in the pressure in the pulmonary arteries resulting from a variety of diseases including chronic infectious diseases, lung diseases and left heart diseases (LHD). It is a global health problem and accounts for a substantial portion of cardiovascular …
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Relaxin: a new cardiovascular hormone in humans? Comparative potency and mechanisms of action
… the effects of relaxin in small human resistance arteries ex vivo using wire myography obtained from gluteal biopsies taken from patients with coronary heart disease (CHD) and normal left ventricular systolic function. We also studied the same effects in larger calibre arteries (internal mammary) …
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Interactions between potassium channels and serotonin in pulmonary arterial hypertension
Pulmonary arterial hypertension (PAH) is a progressive disease which results from increases in mean pulmonary artery pressure and pulmonary vascular resistance. If untreated it leads to right ventricular failure and death. 5-Hydroxytryptamine (5-HT) has been implicated in the disease process and is …
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Design of Percutaneous Dual Propeller Pump to assist Patients with Single Functional Ventricle
… ventricle, which perfuses both the systemic and pulmonary circulation in parallel. A three-stage palliation procedure, including the final Fontan Completion, is often adopted by surgeons to treat patients with such CHDs. However, the most common outcome of this surgery, an extra-cardiac total …
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The role of mitochondria in regulating smooth muscle cell proliferation and migration in pulmonary hypertension
Remodeling of the pulmonary arteries with proliferation and migration of pulmonary arterial smooth muscle cell (PASMC) is the hallmark of pulmonary hypertension, a proliferative disease with poor prognosis, which is exacerbated by hypoxic conditions. Hyperproliferation of PASMC underlies the …
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Biochemical and Functional Investigations into the Contribution of SOX17 Mutations to the Pathogenesis of Pulmonary Arterial Hypertension
Pulmonary arterial hypertension (PAH) is a rare fatal disease characterised by endothelial dysfunction and obliteration of small pulmonary arteries. The resulting increase in pulmonary arterial pressure and right ventricular afterload ultimately causes death by right heart failure. Current …
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Deep forward and reverse phenotyping for genetic discovery in pulmonary arterial hypertension.
Pulmonary arterial hypertension (PAH) is a rare disease characterised by constriction and obliteration of small pulmonary arteries, which leads to increased pulmonary vascular resistance and in consequence, right ventricular failure and death. The accurate clinical diagnosis of pulmonary …
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La Metabolomica: una nuova era in Cardiologia. Le nostre esperienze originali nei campi dell' insufficienza cardiaca, della cardiopatia ischemica e dell' ipertensione polmonare
… failure; b) Stable coronary artery disease; c) Pulmonary hypertension in systemic sclerosis. Heart Failure Heart failure (HF) is characterized by a series of maladaptive metabolic changes, which have recently been proposed as a new therapeutic target. A proton nuclear magnetic resonance (1H …
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Resultados hemodinámicos y clínicos de la angioplastia pulmonar con balón en pacientes con hipertensión pulmonar tromboembólica crónica en un centro de referencia en Bogotá, Colombia
Introducción: La hipertensión pulmonar tromboembólica crónica (HPTEC) es causada por obstrucción trombótica persistente de las arterias pulmonares y posterior remodelación vascular. El tratamiento establecido es la cirugía. Sin embargo, en pacientes inoperables la angioplastia pulmonar con balón …
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Ruido de la aviación militar y sus efectos sobre el corazón de las tripulaciones y personal de tierra
… of transmitral flow and reduction of flow in pulmonary arteries. This alteration of transmitral flow and reduction may be a sign of severe cardiac alterations in time. Psychoacoustic parameters indicate that cardiac wear is due to exposure to low frequency sound in high values of energy that …