Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 38 for “"Pulmonary arterial hypertension (PAH)"”.
-
The prevalence and risk factors associated with pulmonary arterial hypertension among HIV-infected individuals in a tertiary hospital in Durban
… health burden and a risk factor for developing pulmonary arterial hypertension (PAH). Africa carries the largest burden of HIV globally. However, data summarizing the epidemiology of PAH remains unclear. The lungs are often affected by disorders associated with HIV-infection. HIV-infected …
-
Risk Factors, Mechanisms and Therapeuthic for Right Heart Failure Associated with Pulmonary Hypertension
… This is particularly relevant for patients with pulmonary arterial hypertension (PAH), where RV failure in the setting of pressure overload is the leading cause of death. PAH will be introduced in the 2nd chapter of this thesis by comparing and refining contemporary mortality risk assessment …
-
Role of Nudt21 Mediated Alternative Polyadenylation and Hyaluronan In The Development of Pulmonary Hypertension
<p>Pulmonary hypertension (PH) is a progressive disease with serious effects on quality of life and life expectancy of patients. PH is a complex disease that likely develops due to multiple influences, and no curative treatments exist for this disease. It has been shown that alternative …
-
Pharmacovigilance in Post-Marketing: Risk Assessment and Reporting Standards
… released into the market over the recent years, pulmonary arterial hypertension (PAH) remains to be a rapidly progressive disease with poor prognosis. Over time the arteries stiffen and tighten subsequently leaving the heart to pump harder to try and provide enough blood to the body. The extra …
-
Arrhythmias in Pulmonary Hypertension
Cardiac arrhythmias are common in patients with pulmonary arterial hypertension (PAH) due to structural and electrical remodelling of the right heart, and are associated with adverse clinical outcomes. This study investigated the prevalence and clinical significance of conduction abnormalities and …
-
Modulating Bone morphogenetic protein (BMP) and Transforming growth factor-beta (TGF-β) signalling with green tea catechins in mammalian cells
Familial cases of pulmonary arterial hypertension (PAH) are often caused by germline mutations, the most common being a loss of characteristic mutation in the BMPR2 gene, a member of the TGFβ Superfamily. In this study, it was hypothesised that these green tea catechin compounds might inhibit TGFβ …
-
Ultrasonographic circumferential strain pattern analysis of the cardiac septal wall in rodents with experimental pulmonary hypertension.
Pulmonary arterial hypertension (PAH) remains a devastating disease. Early diagnosis remains challenging, but is associated with improved outcomes. Rodent models have been extensively used to investigate PAH. Ultrasonographic strain pattern analysis provides a novel method of assessing cardiac …
-
Ultrasonographic circumferential strain pattern analysis of the cardiac septal wall in rodents with experimental pulmonary hypertension.
Pulmonary arterial hypertension (PAH) remains a devastating disease. Early diagnosis remains challenging, but is associated with improved outcomes. Rodent models have been extensively used to investigate PAH. Ultrasonographic strain pattern analysis provides a novel method of assessing cardiac …
-
Investigating the impact of endothelial BMPR2 loss on the proliferative response to bone morphogenetic protein 9 in pulmonary arterial hypertension
Objective: Pulmonary arterial hypertension (PAH) is a disease of proliferative vascular occlusion that is strongly linked to heterozygous mutations in BMPR2, the gene encoding the bone morphogenetic protein (BMP) type II receptor (BMPR-II). The endothelial-selective BMPR-II ligand, BMP9, has been …
-
Exploring the Impact of Endothelial Bone Morphogenetic Protein Receptor 2 Loss on Phosphoinositide and Cytoskeletal Assembly Dynamics and the Pathobiology of Pulmonary Arterial Hypertension
… species in specific intracellular compartments. Pulmonary arterial hypertension (PAH) is a disease characterized by lung vascular obstruction, endothelial dysfunction, and heterozygous germline mutations in BMPR2, which encodes the bone morphogenetic protein (BMP) type II receptor. Previous …
-
Liposomal delivery of PDE5 inhibitors and UT-15C to human erythrocytes
… However, erythrocytes from patients with pulmonary arterial hypertension (PAH) fail to release ATP in response to the physiological stimuli of exposure to low oxygen tension or mechanical deformation of a magnitude these cells would encounter in the pulmonary circulation. This defect could …
-
Influences of first-line oral monotherapy on outcomes in Pulmonary Arterial Hypertension in association with Connective Tissue Disease.
Background Pulmonary arterial hypertension (PAH) is a rare progressive disease with no known cure. Of various aetiologies, PAH in association with connective tissue disease (PAH-CTD) is the most rapidly progressive and difficult to treat. Management of PAH has evolved significantly in the past ten …
-
Therapeutic Targeting of BMP and TGF-β Signalling Pathways for the Resolution of Pulmonary Arterial Hypertension
… proliferation and apoptosis resistance of pulmonary arterial smooth muscle (PASMCs) and endothelial cells (ECs) has been attributed to the pathogenesis of pulmonary arterial hypertension (PAH). It is an incurable cardiovascular disorder, which leads to right heart failure and death, if left …
-
Prostanoid-mediated Inhibition of IL-6 Trans-Signalling in Pulmonary Arterial Hypertension: a Role for Suppressor of Cytokine Signalling 3?
Pulmonary arterial hypertension (PAH) is a rare, devastating disease with no cure. Current treatment consists of a cocktail of vasodilators which relieve symptoms of PAH but do not treat the cause. Thus, there is a need for novel drugs that target the underlying pathological causes of PAH. PAH is a …
-
Deep learning of regulatory sequence variation in Pulmonary Arterial Hypertension
Pulmonary arterial hypertension (PAH) is a rare and fatal lung disease. To date, in only a third of idiopathic patients, the cause can be attributed to rare genetic variation in the protein-coding space. The sequencing of 13,343 whole genomes by the NIHR BioResource for Translational Research – …
-
Phenotype – genotype associations in a large cohort of patients with pulmonary arterial hypertension
Idiopathic and heritable pulmonary arterial hypertension (PAH) are rare diseases with a poor prognosis. There is significant heterogeneity in clinical features at diagnosis, and in a proportion of patients there is a genetic cause of the disease. This clinical and genetic heterogeneity has hindered …
-
Role of plasma membrane ATPase4 in the pathophysiology of pulmonary arterial hypertension
Background Pulmonary Arterial Hypertension (PAH) is a progressive vascular disease characterised by pulmonary vascular remodelling, inflammation, and excessive apoptosis of pulmonary arterial endothelial cells (PAECs). Elevated levels of pro- inflammatory cytokines such as TNF-α are a hallmark of …
-
Molecular and cellular mechanisms implicated in the regulation of cellular PMCA expression during pulmonary arterial hypertension
Pulmonary arterial hypertension (PAH) is a rare, life-threatening disorder typified by elevated pulmonary vascular resistance, right ventricular hypertrophy, right heart failure and ultimately death. This disease has no current cure and available therapies alleviate vasoconstriction but do not …
Page 1 of 2