Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 25 for “"Pulmonary Infections"”.
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Transformation of Lymphocytes From Patients With Histoplasmosis and Other Pulmonary Infections
… to be crucial in host defense against fungal infections. Patients with T lymphocyte defects are unable to resist even minor exposures to fungi and some patients with a responsive CMI have been reported to be unable to combat the infections. This may be due to immunosuppressive factors. The …
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Hypoxia and the regulation of host responses to acute bacterial pulmonary infections
Introduction – Severe pulmonary bacterial infections are frequently complicated by systemic hypoxaemia and, in the context of acute respiratory distress syndrome (ARDS), inappropriately prolonged neutrophilic inflammation. This combination of acute hypoxaemia and persistent inflammatory response …
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The role of E3 ubiquitin ligase CBLB in mediating innate immunity to pulmonary infections
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2026-05-01
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Identifying cross-species regimens for the treatment of rapid-growing and slow-growing nontuberculous Mycobacterium pulmonary infections
… are increasingly significant causes of chronic pulmonary disease. Current treatments are lengthy and often ineffective, with culture conversion often below 60% in refractory patient populations. Due to the close biological relationship between Mycobacterium tuberculosis (TB) and NTM species, TB …
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Untersuchung zu Veränderungen der Lymphozytensubpopulationen im Krankheitsverlauf der Mukoviszidose
… with CF, 23 non-CF Patients with recurrent pulmonary infections and 83 healthy controls. We performed lymphocyte phenotyping with CD3-, CD19-, CD16-, CD56-, CD4-, CD8-, CD11b-, CD57-, HLA-DR-, CD25-, CD45RA-, CD45RO- antigens. Additional immunohistochemistry was performed on lung tissue of …
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Relationship of plasmids in Mycobacterium avium, Mycobacterium intracellulare, and Mycobacterium scrofulaceum
… the environment, from patients without AIDS with pulmonary infections, and from AIDS patients with disseminated MAIS infections. Similar results were seen with a second probe derived from pLR 7, a 15.3 kb plasmid from clinical <i>M. intracellulare</i> strain LR 113. The similarity of plasmids from …
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Modulation of airway mucin glycosylation by Pseudomonas aeruginosa pyocyanin
Cystic fibrosis (CF) patients battle life-long pulmonary infections with the respiratory pathogen Pseudomonas aeruginosa (PA). A favorable niche for PA growth is provided by an overabundance of mucus in CF airways. When compared to that of non-CF individuals, mucus of CF airways has been found to …
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Utilization of Model-Based Approaches to Maximize Efficacy of Antibiotics for the Treatment of Mycobacterium abscessus Pulmonary Infection
… and incidence of Mycobacterium abscessus (Mab) pulmonary infections have increased and been recognized as a major cause of mortality, particularly in certain patient populations, such as cystic fibrosis (CF) patients. Due to the intrinsic multidrug resistance mechanisms and biofilm (BF) …
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Rapid, Quantitative Assessment of Antimycobacterial Water Disinfection based on the Firefly Luciferase Reporter Gene
… infection in humans with immunodeficiency, pulmonary infections in individuals with predisposing lung conditions (e.g., pneumoconiosis), and cervical lymphadenitis in children. Twenty-five to fifty percent of late stage AIDS patients are infected with M. avium. M. avium has been recovered …
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An investigation of the effects of an antimicrobial peptide on the survival of Acanthamoeba and intracellular bacteria associated with Cystic Fibrosis
… are the most notorious pathogens associated with pulmonary infections in Cystic Fibrosis (CF) lung. Treatment is problematic and re-infection is relatively common. It is vital to develop alternative therapies. Antimicrobial peptides are predominant candidates for combatting pathogenic bacteria. …
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Microbial interactions with epithelial surfaces.
… may be also be involved in staphylococcal pulmonary infections. Recently, several community-associated strains of S. aureus have been linked with severe and often fatal pulmonary diseases. I have found that these strains produce superantigens such as toxic shock syndrome toxin-1 (TSST-1), …
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Purification and Characterization of Proteolytic Aspartate Transcarbamoylase (ATCase) from Burkholderia cepacia 25416 and Construction of a pyrB1 Knock-out Mutant
… pathogen of humans causing highly communicable pulmonary infections in cystic fibrosis and immunocompromized patients. The pyrB gene encoding ATCase was cloned and ATCase was purified by the glutathione S-transferase gene fusion system. The ATCase in B. cepacia has been previously classified as …
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Candidate genes other than the CFTR gene as possible modifiers of pulmonary disease severity in cystic fibrosis
… single gene Mendelian disorder characterized by pulmonary disease and pancreatic insufficiency. Pulmonary disease is the major cause of death in CF patients. Although some cystic fibrosis transmembrane conductance regulator (CFTR) genotypes are associated with less severe disease, patients …
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Alternative regulation of the alginate algD operon by an activated AlgB in nonmucoid Pseudomonas aeruginosa is dependent on Sigma 54
… a major virulence factor associated with chronic pulmonary infections in cystic fibrosis patients. Expression of the algD operon for alginate biosynthesis requires three major regulators in association with the ECF sigma factor, σ22, in mucoid strains that are typically defective in anti-sigma …
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Optimization of N-(1-Adamantyl)-3-Aryl Acetamides as Novel Antimycobacterial Agents
… cases per year. Current therapy for active TB pulmonary infections constitutes multiple-drug therapy for greater than six months. Treatment for MDR/XDR TB can extend for several years and includes medications with serious adverse event profiles. Nontuberculous mycobacterial (NTM) infections are …
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The glyoxylate shunt as a target for antibacterial intervention in Pseudomonas aeruginosa
… proportion of drug-resistant, hospital-acquired infections worldwide. These infections are notoriously difficult to treat due to P. aeruginosa’s many intrinsic and acquired resistance mechanisms. Despite the critical need for new antibiotics against P. aeruginosa, the current pipeline is unable …
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Glycan polymeric prodrugs against pulmonary intracellular alveolar infections
… high infectivity and mortality, transmission by pulmonary route of infection, and potential development as a bioweapon. Current antibiotics are limited by poor pharmacokinetic properties, and consequently require high frequency dosing at high concentrations to show promising clinical success. The …
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Effect of growth in biofilms upon antibiotic and chlorine susceptibility of Mycobacterium avium and Mycobacterium intracellulare
… and soil. M. avium and M. intracellulare cause pulmonary infections (tuberculosis) in immunocompetent individuals and bacteremia in immunodeficient individuals (e.g. AIDS). One factor likely influencing the lack of success of antibiotic therapy in patients would be their ability to form …
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Intraoperative Kaudalanästhesie bei Kindern mit hereditären neuromuskulären Erkrankungen : Benefit oder unnötige Risikoerhöhung?
… of life and for preventing complications such as pulmonary infections. Physiotherapy is not sufficiently qualified for preventing muscular contractures, which develop based on a deficiency of movement. As a rule finally operations are required to prolong the ability to walk or stand. Accompanying …
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Rapid, Efficient and Versatile Strategies for Functionally Sophisticated Polymers and Nanoparticles: Degradable Polyphosphoesters and Anisotropic Distribution of Chemical Functionalities
… were designed to load silver ions to treat pulmonary infections, while the cationic nanoparticles are being applied to regulate lung injuries by serving as a degradable iNOS inhibitor conjugates.</p><p>In addition, a direct synthesis of acid-labile polyphosphoramidate by organobase-catalyzed …
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