Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 70 for “"Pulmonary Hypertension"”.
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Arrhythmias in Pulmonary Hypertension
Cardiac arrhythmias are common in patients with pulmonary arterial hypertension (PAH) due to structural and electrical remodelling of the right heart, and are associated with adverse clinical outcomes. This study investigated the prevalence and clinical significance of conduction abnormalities and …
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Pulmonary Hypertension: Insights From the Reservoir-Wave Approach
… reservoir-wave approach to analyze high-fidelity pulmonary arterial (PA) pressure and Doppler flow velocity in 11 patients with varying cardiac diseases. Our specific objectives were to (1) to characterize PA wave pattern and (2) evaluate right ventricular (RV) performance. Wave pressure was …
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Pulmonary hypertension in adolescents with sickle cell disease
… damage that increases the mortality of patients. Pulmonary hypertension is the increase in blood pressure in the pulmonary vasculature causing less blood to reach the lungs. The right side of the heart has to pump harder to compensate for this, which can ultimately lead to right heart failure. …
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Diagnostic, prognostic and therapeutic considerations in primary pulmonary hypertension
The diagnosis of primary pulmonary hypertension (PPH) and prediction of its course, whether treated or untreated, presents several problems. These are of particular relevance when selection of patients for, and timing of heart-lung transplantation is being considered. I performed a retrospective …
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Melatonin as a novel cardioprotective therapy in pulmonary hypertension
Pulmonary hypertension (PH) is characterized by elevated pulmonary arterial pressure which leads to right ventricular hypertrophy and failure. The mechanism involved in the pathophysiology of the disease remains unclear but it is suggested that oxidative stress may trigger cardiovascular …
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Magnetic resonance imaging of the right ventricle in human pulmonary hypertension
Pulmonary Hypertension (PH) is a rare but devastating illness which results in progressive right ventricular (RV) failure and early death. RV function determines survival in all patients with PH but it is difficult to measure accurately using existing clinical techniques. The choice and design of …
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Predicting pulmonary hypertension and outcomes in patients with left heart disease
Pulmonary hypertension (PH) is defined as a rise in the pressure in the pulmonary arteries resulting from a variety of diseases including chronic infectious diseases, lung diseases and left heart diseases (LHD). It is a global health problem and accounts for a substantial portion of cardiovascular …
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Association Between New Bronchopulmonary Dysplasia and Pulmonary Hypertension in Extremely Premature Newborns
Bronchopulmonary dysplasia (BPD) is one of the most significant chronic complications of premature newborns treated in neonatal intensive care units. This thesis provides a deep review of the pathogenesis of BPD, the association of hypoxia with the development of BPD associated pulmonary …
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Pulmonary endarterectomy for chronic thromboembolic pulmonary hypertension in Cape Town, South Africa
Introduction: Pulmonary endarterectomy (PEA) is the only definitive and potentially curative therapy for chronic thromboembolic pulmonary hypertension (CTEPH), associated with impressive improvements in symptoms and haemodynamics. However, it is only offered at a few centres in South Africa. The …
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Pulmonary endarterectomy for chronic thromboembolic pulmonary hypertension in Cape Town, South Africa
Introduction: Pulmonary endarterectomy (PEA) is the only definitive and potentially curative therapy for chronic thromboembolic pulmonary hypertension (CTEPH), associated with impressive improvements in symptoms and haemodynamics. However, it is only offered at a few centres in South Africa. The …
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Risk Factors, Mechanisms and Therapeuthic for Right Heart Failure Associated with Pulmonary Hypertension
… This is particularly relevant for patients with pulmonary arterial hypertension (PAH), where RV failure in the setting of pressure overload is the leading cause of death. PAH will be introduced in the 2nd chapter of this thesis by comparing and refining contemporary mortality risk assessment …
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Effects of xanthine oxidase inhibitors in pulmonary hypertension associated with chronic lung disease
Chronic lung diseases are often complicated with pulmonary hypertension (PH). This can lead to disability and poor prognosis. Oxidative stress has been implicated in the development of PH and right ventricular hypertrophy (RVH).A possible new way to treat lung disease related pulmonary hypertension …
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Role of Nudt21 Mediated Alternative Polyadenylation and Hyaluronan In The Development of Pulmonary Hypertension
<p>Pulmonary hypertension (PH) is a progressive disease with serious effects on quality of life and life expectancy of patients. PH is a complex disease that likely develops due to multiple influences, and no curative treatments exist for this disease. It has been shown that alternative …
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The role of mitochondria in regulating smooth muscle cell proliferation and migration in pulmonary hypertension
Remodeling of the pulmonary arteries with proliferation and migration of pulmonary arterial smooth muscle cell (PASMC) is the hallmark of pulmonary hypertension, a proliferative disease with poor prognosis, which is exacerbated by hypoxic conditions. Hyperproliferation of PASMC underlies the …
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A genome-wide association study in chronic thromboembolic pulmonary hypertension and the ADAMTS13-VWF axis
Chronic thromboembolic pulmonary hypertension (CTEPH) is an important and severe consequence of pulmonary embolism (PE), resulting from failure of thrombus resolution. Identifying genetic risk factors for CTEPH would provide important insights into pathobiology and might allow risk-stratification …
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Investigation of the intracellular pathways required for 5HT-induced mitogenesis and their role in pulmonary hypertension.
ABSTRACT Pulmonary arterial hypertension (PAH) is a rare and progressive disease characterised by increased pulmonary vascular resistance and elevated pulmonary artery pressure, leading to right ventricular failure and eventually death. The monoamine 5-hydroxytryptamine (5HT) has been implicated in …
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Ultrasonographic circumferential strain pattern analysis of the cardiac septal wall in rodents with experimental pulmonary hypertension.
Pulmonary arterial hypertension (PAH) remains a devastating disease. Early diagnosis remains challenging, but is associated with improved outcomes. Rodent models have been extensively used to investigate PAH. Ultrasonographic strain pattern analysis provides a novel method of assessing cardiac …
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Ultrasonographic circumferential strain pattern analysis of the cardiac septal wall in rodents with experimental pulmonary hypertension.
Pulmonary arterial hypertension (PAH) remains a devastating disease. Early diagnosis remains challenging, but is associated with improved outcomes. Rodent models have been extensively used to investigate PAH. Ultrasonographic strain pattern analysis provides a novel method of assessing cardiac …
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Potential cardioprotective effect of chronic, moderate consumption of reduced-alcohol wine in a rat model of pulmonary hypertension
Background: Pulmonary arterial hypertension (PAH) is a severe disease which leads to right ventricular (RV) dysfunction and possibly death. The pathophysiological process of PAH remains unclear but oxidative stress is thought to contribute to arterial and ventricular dysfunction. Red wine has …
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