Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"Pulmonary Endothelial Cells"”.
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Mcp-1 Release Modulation Through Interaction of Pulmonary Endothelial Cells and Mesenchymal Stromal Cells
… therapies such as mesenchymal stromal</p> <p>cells (MSCs) have increasingly shown great promise for ischemic stroke recovery</p> <p>with some therapies already in various stages of clinical trials. Intravenous (IV)</p> <p>administration of the MSCs leads to the entrapment of these MSCs in the …
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Investigating the impact of endothelial BMPR2 loss on the proliferative response to bone morphogenetic protein 9 in pulmonary arterial hypertension
Objective: Pulmonary arterial hypertension (PAH) is a disease of proliferative vascular occlusion that is strongly linked to heterozygous mutations in BMPR2, the gene encoding the bone morphogenetic protein (BMP) type II receptor (BMPR-II). The endothelial-selective BMPR-II ligand, BMP9, has been …
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The effects of cellular quiescence on the antioxidant defense enzymes of bovine embryonic lung fibroblasts: a survey
… in bovine embryonic lung fibroblasts, human pulmonary artery endothelial cells (HPAE) and bovine PAE cell lines were also studied. Our preliminary data suggest that inhibitors of protein and RNA synthesis both cause a significant decrease in the induction of the manganese SOD in bovine …
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Pulmonary vascular malfunction and inflammation during Orientia tsutsugamushi infection
… work was to characterize the activation of the pulmonary endothelium during infection. Although O. tsutsugamushi is considered an endotheliotropic bacterium, no research has been conducted to evaluate changes in the endothelium in vivo during infection. Prolonged activation and loss of barrier …
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The effect of hypoxia on ER-β expression in the lung and cultured pulmonary artery endothelial cells
… exerts protective effects in hypoxia-induced pulmonary hypertension (HPH) via endothelial cell estrogen receptor (ER)-dependent mechanisms. However, the effects of hypoxia on ER expression in the pulmonary-right ventricle (RV) axis remain unknown. Based on previous data suggesting a role of …
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Mechanical regulation of cell-cell junctions
… and physiology of cadherin-expressing cells. In order to establish how force impinges on critical cell functions in healthy or diseased tissue, it is essential to determine the mechanisms by which mechanical force is transduced into biochemical signals. In this dissertation, I provide …
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Engineering approaches to study lung mechanobiology
… approaches to investigate the regulation of the pulmonary blood-gas barrier, and endothelial barrier function in particular. The pulmonary blood-gas barrier consists of airway epithelial cells, which are exposed to the inhaled air, and vascular endothelial cells, which line the blood vessels. In …
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Tie-ing the endothelium: development of an mRNA-based nanotherapeutic to restore microvascular barrier function for the treatment of sepsis-induced multiple organ failure
… novel therapeutic approaches to treat sepsis. Endothelial dysfunction is a hallmark of sepsis to which the loss of Ang/Tie2 signalling, a key regulator of vascular integrity, contributes significantly, making it an attractive therapeutic target. The impairment in Tie2 pathway activity manifests …