Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 7 of 7 for “"Pten deletion"”.
-
INTERACTION OF PTEN DELETION AND C-MYC GAIN IN PROSTATE CANCER PROGRESSION
Prostate cancer is of significant public health importance since it is the most common non-cutaneous cancer and the second leading cause of cancer death among men in the United States. While the majority of prostate cancer patients will not die of the disease and some may not even need treatment, …
-
The Effects of PTEN Deletion on Cell Size and Plasticity in the Hippocampus
… tumor suppressor phosphatase and tensin homolog (PTEN) is the central negative regulator of the phosphatidylinositol 3-kinase (PI3K) -signaling pathway, which mediates diverse processes in various tissues. In the nervous system, the PI3K pathway modulates proliferation, migration, cellular size …
-
Metabolic regulation in Phosphatase and tensin homologue (PTEN) null T cell lymphoma/leukaemia cells
Deletion of PTEN selectively in T cell progenitors in the thymus results in the rapid development of aggressive T cell lymphomas in a mouse model for T-ALL. We showed that PTEN-/- T cell lymphoma/leukaemia cells were metabolically active as they readily took up key nutrients. Thus, they had high …
-
P53R245W Mutation Elicits Metastatic Phenotype In Pten Deficient Prostate Cancer
… prostate-specific p53R245W mutant and Pten deletion to access the role of this common p53 mutant in the pathogenesis and metastasis of prostate cancer. We found that <em>Trp53<sup>R245W/-</sup> Pten<sup>-/-</sup></em> mice have invasive prostate cancer with complete penetrance and …
-
The effect of RAN inhibition on human colorectal cancer cells (CRC)
… to the liver through the effect of K-Ras and Pten mutation (Mt.) (Abbas et al. 2020). This study aimed to assess the hypothesis that the Ran inhibitor mebendazole MBZ reduces cell invasion and metastasis of CRC. I have investigated MBZ effect on the CRC isogenic human cell lines with specific …
-
1á,25(OH)2-VITAMIN D3 IN PROSTATE: INTERSECTION WITH AKT/PTEN AXIS AND ROLE IN SENESCENCE
… occurs due to the loss of tumor suppressor PTEN, we evaluated the effect of Pten loss on 1á,25(OH)<sub>2</sub>D<sub>3</sub>)-mediated antiproliferative effects utilizing mouse prostatic epithelial cells (MPEC) with acute in vitro Pten knockdown or knockout. We found that loss of Pten …
-
Deciphering the Functions of Ets2, Pten and p53 in Stromal Fibroblasts in Multiple Breast Cancer Models
… Ets2 as well as the tumor suppressor genes Pten and p53 in tumorigenesis using conditional knockout mouse models. Importantly, the functions of these genes are assessed in multiple breast cancer models to account for the heterogeneity observed in breast cancer. Additionally, gene expression …