Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"Ptch1"”.
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Desert Hedgehog is a Mammal-Specific Gene Expressed During Testicular and Ovarian Development in a Marsupial
… the expression and protein distribution of DHH, PTCH1 and PTCH2 in the developing testes of a marsupial mammal (the tammar wallaby) to determine whether DHH signalling is a conserved factor in gonadal development in all therian mammals.</h1>
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Ο ρόλος του σηματοδοτικού μονοπατιού Sonic Hedgehog στον καρκίνο του πνεύμονα
… Έγινε μελέτη της έκφρασης των μορίων Shh, Ptch1, Smo, Gli1, Gli2 και FoxM1. Τα αποτελέσματα αποκάλυψαν μια έντονη έκφραση των μορίων του μονοπατιού και αυξημένα ποσοστά ενεργοποίησής του. Επίσης βρέθηκε στατιστικά σημαντική συσχέτιση με τα πλακώδη καρκινώματα και με τα χαμηλού grade …
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The transcription factor Zfx is required for tumorigenesis caused by Hedgehog pathway activation
… following deletion of the inhibitory receptor Ptch1. Co-deletion of Zfx also delayed development of Hh-dependent MB caused by Ptch1 deletion in vivo. In contrast, Zfx was dispensable for the development of the PTEN-dependent brain tumor glioblastoma, showing that a requirement for Zfx is not …
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The Generation of Alternative Transcripts as a Means of Regulating Phosphorylation in Sonic Hedgehog Medulloblastoma
… (RNA-Seq) datasets from murine P7 GNPs and Ptch1+/− MBs to identify 12 candidate genes exhibiting isoform-level differences in phosphorylation. Among these, Ring Finger Protein 220 (Rnf220) and Septin-9 (Sept9) emerged as key candidates, with their longer phosphorylated isoforms showing …
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Structural Investigations of Porcupine and Dispatched-1 in Wnt and Hedgehog Morphogen Biogenesis
… an open state, unlike its structural homologues PTCH1 and NPC1, whose extracellular/luminal domains adopt a closed state. Wnt signaling is essential for embryonic development and adult tissue homeostasis, and aberrant Wnt signaling is frequently associated with cancer. Palmitoleoylation on the …
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Pten Function in Postnatal Brain Development and Tumorigenesis
… 7, 13 and 16 and had mutations in the gene <em>Ptch1</em>. Therefore the PI3K and Shh pathways cooperate in generating medulloblastomas.</p> <p> Our results show Pten is required for appropriate positioning of neuronal differentiation and preventing ectopic neural stem/progenitor proliferation …
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The Role of Notch Signalling in Amplifying the Cellular Response to Sonic Hedgehog during Dorsal-Ventral Patterning of the Spinal Cord
… of p3 marker Nkx2.2 and Shh target gene Ptch1. In addition, the Notch target gene in chicken embryo HAIRY2 was demonstrated to be also the target of Shh signalling in the ventral midline and to play role in induction and maintenance of the p3 fate. Missexpression of this gene in the …