Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 56 for “"Psychostimulant"”.
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Metabolic Stability And Pharmacokinetics In Lead Optimization Of Potential Anti-Psychostimulant Pharmacotherapies
Drug addiction is a chronic disorder characterized by obsessive and uncontrollable drug-seeking behaviors. It is a major public health problem globally as well as in the United States. Apart from causing severe medical complications it also leads to several socioeconomic problems like healthcare …
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EFFECTS OF BACLOFEN AND PHENMETRAZINE ON NEURONAL SIGNALING PATHWAYS IMPLICATED IN PSYCHOSTIMULANT ADDICTION
Substance use disorders (SUDs) and addictions are serious mental conditions with profound consequences on both an individual and society. In the United States alone, the total estimated cost of substance abuse, including lost productivity-, crime-, and health- related costs, exceeds $700 billion …
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Evaluation of age differences in locomotor activity following psychostimulant administration in adolescent versus adult mice
… administration of an equivalent dose of psychostimulant (e.g. cocaine, amphetamine, methamphetamine), adolescent rodents are commonly observed to locomotor stimulate to a lesser magnitude than that of adults. However, recently conflicting reports have been published showing adolescents to …
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Dopamine Transporter (DAT) and Metabotropic Glutamate Receptor 5 (MGLU5) Irreversible Probes for Identifying Anti-Psychostimulant Therapeutics
Numerous behavioral studies indicate that dopamine transporter (DAT) inhibitors and metabotropic glutamate receptor 5 (mGlu5) negative allosteric modulators (NAMs) possess promising anti-addiction therapeutic properties. However, the lack of human DAT (hDAT) and mGlu5 X-ray crystal structures makes …
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IMPORTANCE OF THE D2 RECEPTOR FOR ONE- AND MULTI-TRIAL PSYCHOSTIMULANT-INDUCED BEHAVIORAL SENSITIZATION IN PREWEANLING RATS
<p>The neural mechanisms mediating one-trial and multi-trial behavioral sensitization during early ontogeny are poorly understood. The purpose of this thesis was to assess the importance of D2-like receptors for the induction of cocaine- and methamphetamine-induced one-trial and multi-trial …
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Dopamine Transporter (DAT), Nicotinic Acetylcholine Receptor (nAChR), and Metabotropic Glutamate Receptor 2 (mGlu2) Irreversible Probes For Identifying Anti-Psychostimulant Therapeutics
… rationally designing new therapeutics for psychostimulant abuse and addiction. The objective of this research was to develop irreversible chemical probes based on promising anti-addiction lead compounds (i.e., pyrovalerone, bupropion, BINA, etc) to map their binding sites and poses within …
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Incidence rates of psychostimulant and non-stimulant medications among children and adolescents in Iceland : before, during, and after the COVID-19 pandemic
… study examined the incident dispensations of psychostimulant and non-stimulant medication among children and adolescents (6–18 years) by sex and age group in Iceland before, during and after the COVID-19 pandemic. Methods: Information on prescriptions and dispensations of psychostimulant and …
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Exploring the in vitro effects of chronic methamphetamine exposure on selected cancer cell lines
Methamphetamine (METH) is a potent psychostimulant widely associated with neurotoxicity and oxidative stress. Although its acute effects are well documented in multiple organ systems, the cellular consequences of chronic METH exposure in cancer biology remain poorly defined. Understanding how …
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IS BRAIN CHOLESTEROL THE MISSING CULPRIT IN DRUG ADDICTION?
Chronic psychostimulant exposure alters the signaling of G-protein coupled receptors (GPCRs), which is associated with drug relapse. Although the molecular mechanisms remain unknown, scant evidence suggests a potential role of membrane lipids especially cholesterol in regulation of …
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Assessment of sex differences and amphetamine on schedule-induced polydipsia
… in patterns of compulsive use of AMPH. Regarding psychostimulant action, female rats have been reported to be more vulnerable to the reinforcing effects of psychostimulants. In the current study, schedule-induced polydipsia (SIP), an animal model of compulsive behavior, was applied for the further …
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Ventral Tegmental Area Neuronal Responses to Methylphenidate Correlated to Behavioral Responses of Adolescent and Adult Rats
<p>Methylphenidate (MPD) is a psychostimulant used in the treat treatment of attention deficit hyperactivity disorder and more recently is being used as a cognitive enhancement and recreational drug. Its therapeutic effects are not fully understood, nor are the long term effects of the drug on …
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Effects of Cocaine Sensitization on Drug Self-Administration, Mesocorticolimbic SAPAP Levels, and Prefrontal Ionotropic Glutamate Receptors
… elevation in drug seeking behavior for psychostimulant sensitized animals. For specific changes at the PSD, we hypothesized that acute cocaine exposure and/or cocaine sensitization would alter iGluRs levels in the mPFC, and SAPAP levels in multiple sites of the mesocorticolimbic system. …
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Methamphetamine and amphetamine differentially affect associative learning: behavioral and neurobiological correlates
… aspects of the addiction process by examining psychostimulant-induced alterations of associative learning, and how specific neurobiological mechanisms, namely glucocorticoid or dopamine receptor activation, contribute to these alterations. A second goal was to investigate potential differences …
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Design and Synthesis of CB1 Receptor Ligands and Synthesis of Amphibian Alkaloids
… for the treatment of cannabinoid and psychostimulant addiction. In this study, we designed, synthesized, and established the CB1 affinity for the 1,5-diaryl-1,2,3- triazole esters, a series of 4,5-diaryl-1-substituted-1,2,3-triazole analogues and a series of 4,5- …
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Methamphetamine and cocaine effects on dopamine neurons in a rat model of developmental stress and attention-deficit/hyperactivity disorder
… both associated with a higher risk of abusing psychostimulants; drugs that act on the dopaminergic system to elicit a sense of reward. Central to dopamine regulation is the dopamine transporter (DAT), which is responsible for the rapid reuptake of released dopamine and therefore the regulation …
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Gabab Regulation of Methamphetamine-Induced Associative Learning
… to identify the neurobiological underpinnings of psychostimulant addiction and develop efficacious drug therapies to compliment the current mainstay treatment of behavioral/cognitive therapy.</p><p>Re-exposure to cues associated with psychostimulants (e.g., drug paraphernalia) increase neuronal …
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Talking Story About Quitting Pugua - An Exploratory Study on Self-Driven Cessation of Betel Nut (Pugua) Chewing on Saipan
… causes cancer, its addictive properties as a psychostimulant, cultural ties in Micronesia, and influences in social settings make giving up this habit a difficult feat. Minimal research is available on betel nut chewing in Micronesia, specifically in the CNMI, and existing research is focused …
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Diverse Kappa Opioid Receptor Agonists: Relationships Between Signaling and Behavior
… interest for the treatment of cocaine and other psychostimulant addictions, because there are currently no available medications for these diseases. Studies in humans and animals, however, have shown that activation of the KOR also causes negative side effects such as hallucinations, aversion and …
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EFFECTS OF OPTOGENETIC ACTIVATION AND PHARMACOLOGICAL MODULATION OF DOPAMINE NEURONS
… healthy volunteers treated with amphetamine, a psychostimulant drug and dopamine releaser. Conversely, antipsychotic drugs may reduce positive symptoms by blocking dopamine receptors. This study used optogenetics to explore how drugs that alter neurotransmission, might alter behaviors occurring …
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