Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 203 for “"Psychiatric disorders"”.
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Converging biochemical pathways in psychiatric disorders
According to the World Health Organization, neuropsychiatric diseases account for approximately one third of years lost to disability. Yet, despite this huge disease burden, there is a lack of new treatments under development: approved treatments all essentially target the same target(s), if the …
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Prioritisation of candidate genes for psychiatric disorders
The application of genome-wide association studies and next-generation sequencing has had limited success in identifying causal genes for complex diseases. Bipolar disorder is one such disease whose aetiology has not been elucidated despite the application of these technologies. Candidate gene …
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A Potential Role For Sap97 In Psychiatric Disorders
… understand the genetic architecture of neuropsychiatric disorders, such as autism spectrum disorder (ASD) and schizophrenia (SCZ). We attempt to understand the functional significance of the gene synapse associated protein of 97KDa (SAP97) and identify a novel role for SAP97 in the etiology …
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Cellular immune mechanisms of psychiatric disorders and the stress response
Multiple psychiatric disorders have been associated with abnormalities in the immune system. As I summarise in my opening chapter (Chapter 1), evidence from human and animal studies suggests that the immune system may be implicated in the pathogenesis of these disorders, at least in a subset of …
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An assessment of reconsolidation blockade to disrupt memories relevant to psychiatric disorders
… may offer a potential tool for the treatment of psychiatric disorders characterised by maladaptive memories, including drug addiction and post-traumatic disorder. Given the importance of instrumental associations in supporting drug addiction experiments in Chapters 3 & 4 aimed to disrupt …
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ROLE OF CELLULAR STRESS RESPONSES IN THE PATHOPHYSIOLOGY AND TREATMENT OF PSYCHIATRIC DISORDERS
… conditions classified among the stress-related psychiatric disorders. Not only it is one of the leading causes of disability worldwide but is also associated with poor treatment response and high rate of relapse, which dramatically increase the risk of death of affected individuals. Stressful …
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Psychiatric disorders as an outcome of neurological insult : a computation of relative risk
… this study was to examine the relative risk of psychiatric disorders occurring in patients diagnosed with neurological disorders. This study separately computed the relative risk ratios for identified psychiatric disorder (i.e., anxiety, mood disorders, somatization, schizophrenia, alcohol …
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Relationships between Dimensions of Religiosity and Internalizing and Externalizing Psychiatric Disorders: A Twin Study
… religiosity and internalizing and externalizing psychiatric disorders. Dimensions of religiosity were found to be largely influenced by additive genetic and unique environmental effects, with little influence observed from common enviromental effects. Multidimensional analyses found that the …
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INVOLVEMENT OF OXIDATIVE BALANCE IN THE ETIOLOGY, PATHOPHYSIOLOGY AND TREATMENT OF STRESS-RELATED PSYCHIATRIC DISORDERS
Psychiatric disorders are severe and heterogeneous pathologies affecting an individual’s cognition, emotional regulation and behaviour. In 2019, 1 over 8 people was living with a mental illness, with major depressive disorder (MDD) identified as the leading global cause of disability, and with the …
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Development of human functional and structural brain networks in adolescence and its relevance to psychiatric disorders
… coincide with a period of increased risk of neuropsychiatric disorders, which generally have their highest rates of clinical incidence in the first two decades. Since many neuropsychiatric disorders display sex differences in both prevalence or clinical presentation, this raises the question of …
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GPR50, a potential factor involved in psychiatric disorders interacts with Alzheimer’s disease-related protein β- secretase (BACE1)
… of GPR50’s potential association with psychiatric disorders and Alzheimer’s disease. Firstly, studies on expression levels revealed that when GPR50 was over-expressed, BACE1 protein expression was up-regulated in SH-SY5Y cells, but down-regulated in HEK293 cells, suggesting a …
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Psychiatric disorders and suicidal behaviour in patients seen at a transgender clinic in Cape Town, South Africa
… are a vulnerable population at risk of psychiatric disorders and suicidal behaviour. Despite this, there is a lack of research on the prevalence of mental health conditions and suicidal behaviour amongst transgender individuals in South Africa. Aim: To assess the prevalence of …
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Impact of co-occurring psychiatric disorders and traumatic brain injury on speech-language treatment: Speech-language pathologists’ perspectives
… brain injury (TBI) with higher rates of psychiatric disorders. This study investigated speech-language pathologists’ (SLPs) perspectives on the prevalence of co-occurring psychiatric disorders in the TBI population and its impact on speech-language treatment. Interviews were conducted …
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Characterization of the Roman lines/strains of rats as a genetic model of psychiatric disorders: a behavioral and brain dialysis study
State of the art Depressive disorders are fairly prevalent in the general population, with a higher rate in women compared to men, are disabling, since they can significantly impair psychosocial functioning, and are typically associated with high mortality due mainly to the high rate of suicides …
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Towards precision medicine in psychiatry: investigating the contribution of cellular aging, pleiotropy and gender differences in psychiatric disorders and pharmacological response
Severe mental disorders such as bipolar disorder (BD), schizophrenia (SZ) and major depressive disorder (MDD) are characterized by a substantial socio-economic burden. Pharmacological treatment is the mainstay in the acute phase of severe mental disorders as well as in the prevention of …
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Large-scale Functional Connectivity in the Human Brain Reveals Fundamental Mechanisms of Cognitive, Sensory and Emotion Processing in Health and Psychiatric Disorders
… temporal gyrus, cerebellum and angular gyrus. In psychiatric disorders, large-scale functional connectivity is typically assessed during resting-state (i.e. no task or stimulus). However, disorder-dependent alterations in functional network architecture may be more or less prominent during a …
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