Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"Pseudomonas exotoxin"”.
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Next-Generation version of pseudomonas exotoxin a based immunotoxins with reduced immunogenicity for triple negative breast cancer (TNBC) treatment
… (scFv) antibody to a truncated mutant of Pseudomonas Exotoxin A (ETA') and deimmunized version of (ETA') RG7787, herewith termed (dETA') introducing a cysteine in position R456. Using the bacterial expression vector pMT, functional (scFv)-ETA' and scFv-dETA' were periplasmically expressed …
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Development of recombinant immunotoxins targeting overexpressed cell surface biomarkers trophoblast cell-surface antigen 2 and mesothelin for cervical cancer treatment
… immunotoxin candidates based on truncated Pseudomonas exotoxin A (ETA) or its deimmunized version (dETA) with an R456T point mutation to compare their cytotoxicity activity towards cancer cells. Medical Biotechnology & Immunotherapy Research Unit Institute for Infectious Disease & Molecular …
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Herstellung und Charakterisierung rekombinanter Immunotoxine aus anti-PSMA single-chain Antikörperfragmenten zur Therapie des Prostatakarzinoms
… scFv A5 rekombinant an eine verkürzte Form des Pseudomonas Exotoxin A (PE40) gekoppelt, dem die in der Natur vorkommende Zellbindungsdomäne Ia fehlt. Diese wurde durch A5 ersetzt, was zu einer Spezifität gegenüber PSMA-exprimierenden Zellen führte. <br>Das bakteriell exprimierte und …
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Immunotoxin Monotherapy and Combinatorial Therapy With Immune Checkpoint Inhibitors for Malignant Brain Tumors
… antibody (mAb) with domains II and III of Pseudomonas exotoxin A (PE38KDEL), and NZ-1-IT was developed by fusing the scFv of the NZ-1 mAb with PE38KDEL. D2C7-IT reacts with both the wild-type epidermal growth factor receptor (EGFRwt) and the EGFR variant III (EGFRvIII), two overexpressed …
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Development and Characterization of recombinant immunotoxins for cervical carcinoma
… demonstrated greater penetration properties. Pseudomonas exotoxin A (ETA) is a highly cytotoxic enzyme that modifies elongation factor 2 of the cell. This modification is irreversible and arrests protein synthesis thereby causing cell death. ETA is prone to causing a humoral response within …
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Development Of Recombinant Immunotherapeutics for Triple-Negative Breast Cancer (TNBC)
… to achieve targeted destruction of cancer cells. Pseudomonas exotoxin A (ETA) is a potent enzyme that disrupts the function of eukaryotic elongation factor 2, causing inhibition of protein synthesis and leading to cell death. Due to the bacterial origin of ETA, scientists have discovered that it …