Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"Pseudo-disaccharide"”.
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Synthetic Studies on Tunicamycin Towards the Discovery of Antimetastatic Agents
… on tunicamycin cyclitol analogs. The complex pseudo-disaccharide and nucleoside segments are assembled in a one-pot Büchner-Curtius-Schlotterbeck reaction in a wet solvent system. A series of DPAGT1 inhibitors can be synthesized in 11-12 chemical steps from the commercially available starting …
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Synthesis of side-chain-modified mycothiol analogues incorporating carbazole quinones, and evaluation as inhibitors of enzymes in the Mycobacteria
… stress. The biosynthetic pathway to this pseudo-disaccharide has been elucidated and a range of mycothiol-dependent enzymes have been identified. Compounds A.3, which have naphthoquinonyl units tethered to the pseudodisaccharide core, have significant inhibitory activity against mshB and …
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Synthesis and Biological Evaluation of Novel Glycomimetics
… using pyrone cycloaddition to synthesise pseudodisaccharides as potential Golgi α-mannosidase II inhibitors. The synthesis is performed over seven steps. Further optimisation is needed to increase the overall yield. Also, an enzyme assay has to be performed to confirm the biological …
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Synthesis and Biological Evaluation of Novel Glycomimetics
… using pyrone cycloaddition to synthesise pseudodisaccharides as potential Golgi α-mannosidase II inhibitors. The synthesis is performed over seven steps. Further optimisation is needed to increase the overall yield. Also, an enzyme assay has to be performed to confirm the biological …