Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"Proximity Proteomics"”.
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TO INVESTIGATE THE ROLE OF RNF8 IN REGULATING MITOTIC PROGRESSION IN GLIOMAS
… but its exact role remains unknown. Using RNF8 proximity proteomics, we find that RNF8 interacts with MAD2 and CAMK2D via its RING and FHA domains respectively to activate the SAC response. The physiological relevance of our mechanistic findings is illustrated in GSCs whereby the overexpression …
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Mechanisms of TRIM21-directed intracellular degradation
… Then, I detail my development of two proximity-proteomics screens and a whole-genome CRISPR/Cas9 knockout screen for TRIM21 interacting partners, in both Trim-Away and adenovirus neutralization contexts. Collectively, the data from these experiments led me to hypothesize that the …
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Statistical Inference and Community Detection in Proximity and Spatial Proteomics: Resolving the Organization of the Neuronal Proteome
… advances in protein mass spectrometry (MS), aka proteomics, haveenabled high-throughput quantification of spatially-resolved, subcellular-specific proteomes. Biological insight in these experiments depends upon sound statistical analysis. Despite the myriad of existing proprietary and open-source …