Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 19 of 19 for “"Proximal tubules"”.
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Stress response genes in the human proximal tubules
… was to determine if the immortalized HK-2 human proximal tubule cell line could provide a model system to study the stress response of the proximal tubule cell. Heat stress, elevated temperature at 42.5°C for 1 hr, caused a marked increase only in hsp 70 mRNA and protein, but not that of hsp …
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Gamma-Glutamyltransferase- Is it a Biomarker of oxidative stress?
… in human fetal liver (HFL cells) and human renal proximal tubules epithelial cells (hRPTE cells). The results suggest that there is an increased excretion of GGT into the extracellular medium for hRPTE cells and an increase in GGT level for HFL cells. The conclusion is that GGT protein may respond …
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A ROLE FOR ANGIOTENSIN-(1-7) TO ATTENUATE ADVANCED GLYCATION END PRODUCT -INDUCED MYOFIBROBLAST TRANSITION IN THE NRK-52E RENAL PROXIMAL TUBULE CELL LINE
… to mesenchymal transition (EMT) of the proximal tubules cells. Advanced glycated end product (AGEs) including methylglyoxal-modified albumin (MGA) may contribute to the development and progression of diabetic nephropathy via activation of the receptors for AGE (RAGE) and the RAS. The RAS …
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STUDIES ON ANGIOTENSIN-(1-7) AND MITOCHONDRIA: THE ROLE OF AN INTRACELLULAR RENIN-ANGIOTENSIN SYSTEM WITHIN THE KIDNEY
… activity in the kidney, specifically in the proximal tubules and in a human proximal tubule cell line. Utilizing the human tubule cells, we purified and identified the Ang-(1-7) degrading activity as Dipeptidyl-Peptidase 3 (DPP 3). Given the bioactive role of Ang-(1-7) counteracting the …
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The accumulation and distribution of Evans blue in the kidney of rats fed normal or low magnesium diets
… by pinocytosis by the cells of the renal proximal tubules, Evans blue served as a suitable marker of the vacuolar apparatus for these studies. Rats were injected intravenously with Evans blue and sacrificed at either 1/2, 1, 3, or 12 hours post-injection. Kidneys were removed and …
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Der Transport anionischer Substanzen durch die basolaterale Membran proximaler S2-Segmente der Kaninchenniere : inverse Beziehung zwischen der Affinität zum p-Aminohippurat-Transportsystem und der Transportrate
… system, which resides in the S2 segment of proximal tubules, is a main tubular secretory system for drugs. Previous studies have shown that the hydrophobicity of drugs is positively correlated with their affinity for the basolateral PAH transporter. Affinity was deduced from inhibition of …
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Molecular Genetic Analysis of FGF23 Bioactivity in the Bone-Kidney Endocrine Axis
… co-transporters are expressed within the renal proximal tubules. The molecular mechanisms of FGF23 signaling were investigated by isolating a novel marker of FGF23 bioactivity using array technology, determining the location of initial FGF23 signaling in the kidney, and by identifying a novel …
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Characterization of the Epididymal Region of the Rooster
… similarities between efferent ductules and proximal tubules of kidney make this a good model for understanding the formation of kidney stones.
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Compensatory renal hypertrophy, mitochondria and redox status
… with increased susceptibility of renal proximal tubule cells to several drugs and environmental chemicals. Furthermore, our lab also showed that overexpression of mitochondrial GSH transporters, the dicarboxylate (DIC, Slc25a10) and 2-oxoglutarate (OGC, Slc25a11) carriers, in NRK-52E …
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Identification of Acyloxyacyl Hydrolase, a Lipopolysaccharide Detoxifying Enzyme, in the Murine Urinary Tract
… presented here, AOAH was found in murine renal proximal tubule cells and in human renal v cortex. Proximal tubule cells are known targets for invading Gram-negative uropathogens and we hypothesize that possessing AOAH may help them degrade the LPS contained within these bacteria. I further found …
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CELLULAR AND MOLECULAR MECHANISMS OF AT2R MEDIATED ANTI-PROTEINURIC ACTIVITY
… C21 rescues megalin surface expression in the proximal tubules potentially by activating Akt-mediated phosphorylation and inactivation of GSK3β in the kidney of male obese Zucker rats fed HSD for 48 hrs. The HSD intake resulted in proteinuria, which was significantly prevented by C21. Moreover, …
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Mechanisms of Exercise-Mediated Restoration of Renal Dopamine D1 Receptor Function in Aging
… Na, K-ATPase and Na, H exchanger, in renal proximal tubules (RPTs) promotes sodium excretion and thus maintains sodium homeostasis. The aging process alters vital organ functions including kidney function. Our previous studies have demonstrated a diminished natriuretic response to dopamine …
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Establishing a Murine Model of Malaria-Associated Acute Kidney Injury and Demonstrating the Contribution of Extrinsic Apoptosis to Tubular Necrosis
… extrinsic apoptosis was detected in the proximal tubules of these mice through immunostaining, immunoblotting, and immunohistochemistry. This finding was corroborated in vitro when inhibition of extrinsic apoptosis rescued human proximal tubular epithelial cells (HPTEC) from …
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Engineering functional kidney tissue using human iPS cells
… show that hiPSC-derived renal organoids possess proximal tubular transporters and receptors; I present optimised techniques to assess the function of these receptors in-vitro and show that these organoids have anion and cation uptake capacities similar to what can be seen in foetal kidney tissue …
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The Role of Megalin in Aminoglycoside-Associated Toxicity in the Kidney
… that amikacin primarily accumulates in the renal proximal tubules, densely located in the medulla, and suggest that megalin, a saturable endocytic membrane transporter, may be largely responsible for aminoglycoside accumulation. Despite the overwhelming evidence for a significant role of megalin …
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Mutational processes in normal human tissues
… within the normal kidney, including glomeruli, proximal tubules, distal tubules and medulla, to estimate an accurate somatic mutation rate of these structures and how they are affected by different environmental exposures. Together, these two studies describe the distinct somatic mutation …
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Pengaruh pemberian infusa daun murbei (Morus alba L.) terhadap gambaran histologi gromerulus dan tubulus proksimal tikus putih (Rattus norvegicus) diabetes mellitus kronik
… can damage the structure of the kidney involving proximal tubule and the glomerulus. It was necessary for the intake of natural antioxidants derived from mulberry leaves the plant. Mulberry leaf contains many active substances include BNJ that is able to reduce blood sugar level and contains …
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Mechanisms of Regulation of Proximal Tubule Sodium Transporters in Obesity-Induced Hypertension
… aim of this study was to determine the role of proximal tubule transporters on the renal sodium handling in obese hypertensive (OP) and lean normotensive (OR) rats. An acute increase in renal perfusion pressure resulted in a blunted natriuretic response in OP vs. OR rats and indicated that …
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Pharmacological Studies of the Signal Transduction Pathways of the a 1a-Adrenbrgic Receptor Subtype
… has been shown to be present in the renal proximal tubules. However, the functions and signal transduction pathways of a1a-ARs in the renal proximal tubule cells are not well understood. In my project, 1 first developed a renal proximal tubule cell model transfected with epitope …