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Showing 1 to 8 of 8 for “"Protonophore"”.
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Calcium: some aspects of subcellular accumulation and distribution in milk
… reduced ⁴⁵Ca accumulation in all fractions. Protonophore caused a small reduction in ⁴⁵Ca accumulation in all cases. Citrate accumulation by fractions was not observed under conditions used for ⁴⁵Ca accumulation.
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The microaerophilic nature of <i>Wolinella recta, Wolinella curva, Bacteroides ureolyticus</i>, and <i>Bacteroides gracilis</i>
… Proton translocation was inhibited by the protonophore carbonylcyanide <i>m</i>-chlorophenylhydrazone. The results confirm the relationship of these organisms to campylobacters.
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Characteristics of Nitrogen- and Iron-Limited Growth in the Diatom Phaeodactylum tricornutum, and in Natural Phytoplankton Populations.
… The method relies on the measured ability of the protonophore carbonyl cyanide m-chlorophenylhydrazone (CCCP) to release unassimilated ammonium from the cell and prevent further assimilation. There was little or no correspondence between the rate of ammonium assimilation and rates of ammonium …
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Characterization of an extremely thermophilic, anaerobic sulphur-dependent archaebacterium
… show a strong inhibitory effect, while a protonophore or a K⁺ ionophore exerted virtually no inhibition. In addition to a Na⁺ gradient the existence of either a H⁺ gradient or a membrane potential is required for growth and generation of ATP. The Na⁺ gradient is possibly generated via a …
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Ionic Control of Porin Permeability
… impact of the only intrinsically produced protonophore, indole. I describe two patterns of indole production depending on the carbon source: glycolytic sugars trigger a strong indole pulse, while gluconeogenic carbon sources result in steady indole production. These behaviours are mainly …
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Design and Synthesis of 8-Trifluoromethyl-Substituted Heterocyclic Small Molecule Mitochondrial Uncouplers for the Treatment of Metabolic Diseases
Metabolism occurs mainly in the mitochondria, or "the powerhouse of the cell." Here, nutrients and sugars from food are broken down and converted into energy through a process called mitochondrial respiration. Through this process, mitochondria provide over 90% of cellular energy. However, during …
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Structure-Activity Relationship Studies of Imidazo[4,5-b]pyrazine Derivatives as Mitochondrial Uncouplers and their Potential in the Treatment of Obesity
Mitochondrial uncouplers have the capacity of passively shuttling protons from the mitochondrial intermembrane space to the mitochondrial matrix, independent of ATP synthase. This results in the disruption of oxidative phosphorylation and increased rate of metabolism as a counter action from the …
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Structure-Activity Relationship Studies of Sphingosine Kinase Inhibitors and Mitochondrial Uncouplers
Sphingosine 1-phosphate (S1P) is a cellular signaling molecule that has been implicated in a variety of diseases including cancer, fibrosis, Alzheimer's, and sickle cell disease. It is formed from the phosphorylation of sphingosine (Sph) by sphingosine kinase (SphK) and SphK exists as two …