Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"Proton-sensing"”.
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Proton-sensing G protein-coupled receptor signalling in inflammation
… pH can exacerbate inflammation, additionally protons may directly depolarise or sensitise sensory neurones to drive the heightened nociception associated with chronic inflammatory diseases such as rheumatoid arthritis and inflammatory bowel disease. Extracellular protons can coordinate …
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Neurochemical drivers of visceral pain: insights into the roles of interleukin-17 and the proton-sensing G protein-coupled receptor GPR68
… with a focus on interleukin 17 (IL-17) and the proton-sensing G protein-coupled receptor (GPCR) GPR68. In the first part of my research, I identified IL-17 as a pro-nociceptive cytokine. This was based on transcriptomic data showing elevated IL17A expression in colonic biopsies from individuals …
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Acidosis Activated GPR68 Promotes Vascular Smooth Muscle Cell Growth
… physiology and pathophysiology. A sub-family of proton sensing GPCRs has been identified that senses changes in extracellular pH and are activated in acidic conditions. One proton sensing GPCR, GPR68, is primarily localized in vascular smooth muscle (VSM) and is thought to signal through …
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Swarna Ramaswamy_Thesis
… gated ion channels.</p> <p>My work on Acid Sensing Ion Channel (ASIC), a proton sensitive ion channel found in central and peripheral nervous system aims to understand the proton sensors and structural changes. The resting state of the ion channel was still poorly understood, as well as the …
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G Protein-Coupled Receptor Signaling in Growth and Inflammation of Vascular Smooth Muscle
… serine protease-activated receptor PAR2 and the proton sensing receptor GPR68, both identified in vascular smooth muscle cells (VSMCs) and believed to signal through multiple intracellular G proteins. In the stimulatory Gs pathway, activation of cyclic AMP contributes to stimulation of multiple …
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Functional and behavioural characterisation of C. elegans acid-sensing DEG/ENaCs
… aim of this thesis was to investigate how proton-sensitive members of the C. elegans DEG/ENaC family regulate cellular processes and drive behaviour. In the initial screen, I identified five C. elegans DEG/ENaCs subunits that can form proton-sensitive homomeric channels when expressed in …
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The role of GABA in plant salinity and hypoxia responses
… GABA biosynthesis (in the cytosol) consumes protons while the final step in catabolism (in the mitochondria) produces protons, thus GABA metabolism can alter pH in a cell. The final aim of this thesis was to examine how pH regulates the activity of Aluminum-activated Malate Transporter …