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Showing 1 to 13 of 13 for “"Proton Radiotherapy"”.
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Assessing The Potential Clinical Impact of Variable Biological Effectiveness In Proton Radiotherapy
<p>It has long been known that proton radiotherapy has an increased biological effectiveness compared to traditional x-ray radiotherapy. This arises from the clustered nature of DNA damage produced by the energy deposition of protons along their tracks in medium. This effect is currently quantified …
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Fine Motor Skills, Processing Speed, And White Matter Integrity Among Pediatric Brain Tumor Survivors Who Received Proton Radiotherapy
… life. A conventional method of treatment, photon radiotherapy (XRT), subjects healthy brain tissue to toxic radiation exposure. This neurotoxicity often manifests as damage to microstructure of white matter tracts, which is measured through diffusion tensor imaging (DTI). Additionally, the …
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Spectral analysis of integrated F-center feedback dosimeter
Proton therapy has yet to implement an in-vivo, real-time, fault-tolerant integral dosimeter. Proposed in this thesis is a conceptual dosimeter to meet such requirements, relying on the radiation-stimulated production of F-centers in alkali halide salts. F-centers are optically active vacancies in …
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Survivin: Regulation by YY1 and Role in Pancreatic Cancer Combination Therapy
… cellular stress events including chemo- and radiotherapy. It is also important to use gained mechanistic understandings of cancer initiation and progression to design logical new approaches to cancer therapy. Pancreatic cancer is one of the most deadly forms of cancer known, and survivin …
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Assessment of and improvements to a stereophotogrammetric patient positioning system for proton therapy
… immobilise and position patients for precision proton radiotherapy. The precision achieved using the stereophotogrammetric (SPG) positioning system is measured, and the shortcomings and errors in using the facemask by the SPG system are measured and analysed. The implementation of improvements …
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Analysis of 3D and 4D proton treatment planning for hepatic tumors
… for 25 patients with hepatic tumors treated by proton radiotherapy. The 4D treatment planning process explicitly takes into account respiratory motion of abdominal organs. A 4DCT scan consists of 10 3D anatomical states, each at an instant of time in the respiratory cycle. 4D treatment planning …
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Evaluation and Clinical Implementation of a Dual-Energy CT Stopping-Power Ratio Mapping Technique for Proton-Therapy Treatment Planning
<p>Proton radiotherapy has the potential to treat tumors with better conformal dose distribution than competing modalities when the rapid dose falloff at the end of the proton-beam range is correctly aligned to the edge of the clinical target volume (CTV). However, its clinical potential is …
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Sub-Millimetre Positron-Emission Particle Tracking Using a CdZnTe Semiconductor Array
… work is in providing on-line beam diagnostics in proton radiotherapy. The PEPT technique was therefore applied to Geant4 simulation data of a 55 MeV and 200 MeV proton beam passing through an organic target to locate the beam-line with uncertainties within the incoming beam width. Such proton …
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Volumetric Scintillation Dosimetry For Scanned Proton Beams
<p>Scanned beam proton therapy is a promising cancer treatment modality which is becoming more widely available with the increasing number of proton radiotherapy centers. Scanned proton beams can produce complex 3D dose distributions, presenting a challenge for adequate quality assurance testing. …
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Atrx Inactivation and Idh1-R132H Drive Preferential Sensitivity to Proton Vs. X-Ray Radiotherapy In Glioma Stem Cells
… photon-based radiation therapy (XRT), proton radiation therapy (PRT) may induce more complex DNA damage and therefore might have the potential to eliminate GSCs. Although previous studies have individually linked IDH mutations, specifically IDH1<sup>R132H</sup>, and ATRX inactivating …
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Investigation of Respiratory Motion Management Techniques For Proton and Photon Radiotherapy of Lung Cancer
<p>Protons as a source of therapeutic radiation can provide a substantial improvement over dose distributions that can be achieved with conventional sources of radiation such as high-energy photons. However, respiratory motion can significantly impact the delivered proton and photon dose …