Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 21 for “"Proton Magnetic Resonance Spectroscopy"”.
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Investigating neuroinflammation in schizophrenia: a proton magnetic resonance spectroscopy (1H-MRS) and cytokine study
… healthy controls. All participants underwent a magnetic resonance imaging scan, which included magnetic resonance spectroscopy with voxels located in the anterior cingulate cortex (ACC) and left thalamus as well as a chemical-shift imaging 2-dimensional slice. Neurometabolites obtained included …
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Ex vivo proton magnetic resonance spectroscopy (1HMRS) of normal, reactive and malignant canine lymph nodes: evaluation of the choline metabolite as a marker for malignancy
… emission computed tomography, whole body magnetic resonance imaging). Magnetic resonance spectroscopy (MRS) is a non-invasive and non-ionizing technique that is well described in the human medical literature and is most frequently used to evaluate the metabolic activity of tissues with …
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Associations between dietary intake, physical activity and intrahepatic fat.
… test, abdominal adiposity was measured by magnetic resonance imaging (MRI), anthropometrics were measured by waist circumference (WC) and BMI, and IHF was measured by proton-magnetic resonance spectroscopy (H-MRS). While none of the dietary intake (quantity or macronutrient composition) or …
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IMAGING THE GLUTAMATERGIC SYSTEM WITH GLUCEST MRI: CYTOARCHITECTURE, AGING, AND INTERVENTION
… alterations. Third, a meta-analysis of twelve proton magnetic resonance spectroscopy studies reveals that repetitive transcranial magnetic stimulation (rTMS), a neuromodulatory treatment for depression, significantly increases glutamatergic metabolites in clinical responders, with evidence of …
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Structural studies of the capsular polysaccharides from some strains of Klebsiella and Cryptococcus neoformans micro-organisms
… and methylation analysis, and the use of proton magnetic resonance spectroscopy and measurement of optical rotatory power to determine the nature of anomeric linkages. The polysaccharides from Klebsiella K4 and X.pnev.moniae ( oxytoca variant) have been shovm to have linear tetra- and …
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Comparison of Magnetic Resonance Spectroscopy (MRS) data in children with and without HIV at 11-12 years
… can be investigated at a chemical level through proton magnetic resonance spectroscopy (1H-MRS). Previous studies in children have largely focused on individual metabolite changes. However, several adult studies have now advanced beyond this to address patterns of metabolic activity that are …
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Magnetic Resonance Spectroscopy Correlates of Outcome in Nonaccidental Trauma
… neuropsychological sequelae in this population. Proton Magnetic Resonance Spectroscopy (<sup>1</sup>H-MRS) provides a promising, quantitative technique by which biochemical substrate levels that result from head injury may predict long term neuropsychological sequelae.</p> <p>The purpose of this …
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Multimodal neuroimaging and early neurobehavioural and developmental correlates of alcohol and methamphetamine exposed infants in Cape Town
… thesis addressed included leveraging structural magnetic resonance imaging (MRI), diffusion tensor imaging (DTI), proton magnetic resonance spectroscopy (1H-MRS) and resting sate functional MRI (rs-fMRI) scans in approximately 100 infants (50 alcohol exposed and a matched number of control, …
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Glutamate Imaging of Mouse Models of Neurodegeneration
… method for measuring glutamate in vivo is proton magnetic resonance spectroscopy (1HMRS) although it has poor spatial resolution and weak sensitivity to glutamate changes. The primary objective of this thesis was to measure pathology induced changes in glutamate levels in mouse models of …
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Development of integrated imaging techniques for investigating biomarkers in glioblastoma
… Various imaging modalities including magnetic resonance imaging (MRI) and positron emission tomography (PET) have been used to study human cancer. In this study, we developed integrated imaging techniques using advanced MR and PET to investigate potential biomarkers in glioblastoma …
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Impaired Behavioral and Pathological Outcomes Following Blast Neurotrauma
… were assayed for neurochemical changes using proton magnetic resonance spectroscopy (MRS) and neuropathology with immunohistochemistry in cognitive regions of brain (hippocampus, amygdala, frontal cortex and nucleus accumbens) Early metabolic changes and oxidative stress were observed along …
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Investigation of potential biomarkers of treatment-resistant schizophrenia
… and to a healthy control group. Two non-invasive magnetic resonance imaging (MRI) techniques were used to examine the structure and integrity of white matter pathways in the brain and potential alterations in the content of neurometabolites; diffusion tensor imaging (DTI) and proton magnetic …
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Influence of maternal human immunodeficiency virus (HIV) and antiretroviral (ARV) drugs on neonate neurometabolism.
… Glu and NAA in 11-year-old HEU children. Using proton magnetic resonance spectroscopy (MRS), metabolite/Cr+PCr ratios were measured in the BG (83 HEU neonates and 45 HUU neonates) and MFGM (65 HEU neonates and 31 HUU neonates) of neonates at a mean gestational age (GA) equivalent of 41.56 weeks …
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Traumatic Brain Injury Mechanisms in the Gottingen Minipig in Response to Two Unique Input Modes
… axonal disruption through immunostaining and proton magnetic resonance spectroscopy. The translation-input injury group metabolite analyses revealed the initial stages of glutamate excitotoxicity while the combined-input injury group showed a clear pathway for glutamate excitotoxicity. …
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A study of ultra-high field strength structural and spectroscopic MR imaging in dementia with Lewy bodies and Alzheimer’s disease
… using ultra-high field, 7 tesla (7T), brain magnetic resonance imaging (MRI) and single voxel proton magnetic resonance spectroscopy (MRS). First, I conducted systematic reviews of the AD and DLB, MRI and MRS literature, demonstrating that DLB is under-represented in high (3T) and ultra-high …
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Multimodal neuroimaging signatures of early cART-treated paediatric HIV - Distinguishing perinatally HIV-infected 7-year-old children from uninfected controls
… identified using neuroimaging modalities such as proton magnetic resonance spectroscopy (1H-MRS), structural magnetic resonance imaging (sMRI), diffusion tensor imaging (DTI), and functional MRI (fMRI). However, few studies have combined multiple MRI measures/features to identify a multivariate …
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Using Multimodal MRI Techniques to Understand the Role of Hippocampus in Schizophrenia
… function. Multimodal MRI techniques including proton magnetic resonance spectroscopy (1H-MRS), cerebral blood volume (CBV), cerebral blood flow (CBF) and functional MRI at 3T were used to examine the metaplasticity model and probe the role of hippocampus in schizophrenia both with (SZ-on) and …
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Sequence Development and Expansion of Zero J-Modulation Echo-Planar Chemical Shift Imaging in Three Dimensions (3D ZJ-EPSI)
… and evaluating this disease is time consuming. Magnetic Resonance Spectroscopy (MRS) has changed this mal-routine significantly in the past few years. MRS can help with better understanding of tumor pathology, study of tumor vascularization and progress, and having a predicting value for the …
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MR-Protonen-Spektroskopie des Linsenkerns bei idiopathischen Handdystonien
… bisher letztlich nicht geklärt ist, bietet die Protonenspektroskopie die Möglichkeit, Stoffwechselveränderungen sowie Änderungen der Gewebszusammensetzung und der Konzentrationen darin enthaltener Stoffe zu untersuchen und so Hypothesen zur Genese der idiopathischen Dystonie herauszuarbeiten. …
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Treatment of HIV associated neurocognitive disorders
… while our secondary endpoint was the change in proton magnetic resonance spectroscopy (1 H-MRS) brain metabolite concentrations. We collected paired plasma-CSF samples in 47 adult participants with and without HAND treated with efavirenz-tenofovir-emtricitabine. We considered 2049 …
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